بررسی اثرات عصاره آبی گیاه شاهی Lepidium sativum بر روی رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ

الموضوعات : فصلنامه زیست شناسی جانوری

فاطمه رحیمی اصل ¹ , مریم خسروی ² , رامین حاجی خانی ³ , جلال صولتی ⁴ , حسین فهیمی ⁵

1 - گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران
2 - گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران
3 - گروه زیست شناسی، واحد تهران شمال، دانشگاه آزاد اسلامی، تهران، ایران
4 - گروه زیست شناسی، واحد گوهر دشت کرج، دانشگاه آزاد اسلامی، کرج، ایران
5 - گروه ژنتیک، واحد علوم پزشکی، دانشگاه آزاد اسلامی، تهران، ایران

تاريخ الإرسال : 06 الثلاثاء , محرم, 1442 تاريخ التأكيد : 22 الإثنين , ربيع الثاني, 1442 تاريخ الإصدار : 15 الإثنين , محرم, 1443

الکلمات المفتاحية: اضطراب, افسردگی, موش سوری, شاهی,

ملخص المقالة :

اضطراب و افسردگی از شایعترین بیماری های روانی هستند. استرس اکسیداتیو از جمله عوامل ایجاد اضطراب و افسردگی است. دانه شاهی دارای خواص ضد التهابی، آنتی اکسیدانی می باشد. هدف از این تحقیق بررسی اثر عصاره آبی گیاه شاهی بر رفتارهای شبه اضطرابی و شبه افسردگی در موش های سوری نر بالغ است. در این تحقیق از موش های کوچک نر با محدوده وزنی 35-30 گرم استفاده شد. ابتدا حیوانات مورد آزمایش به مدت 2 هفته تحت تیمار با عصاره آبی دانه شاهی با دوز های 200 ،400 و 600 میلی گرم بر کیلوگرم قرار گرفتند. پس از پایان دوره تیمار، سطوح اضطراب و افسردگی به ترتیب به وسیله دستگاه ماز بعلاوه مرتفع (EPM) و تست شنای اجباری ارزیابی شد. در هیچ یک از گروه های دریافت کننده عصاره شاهی تغییرات معنی داری در زمان سپری شده در بازوی باز ، تعداد ورود به بازوی باز و فعالیت حرکتی مشاهده نشد. نتایج حاصل از تست شنای اجباری نشان داد که در حیوانات دریافت کننده عصاره شاهی با دوزهای 400 و 600 میلی گرم بر کیلوگرم زمان شنا و زمان بی حرکتی نسبت به گروه کنترل به ترتیب افزایش و کاهش معنی داری داشته است (01/0 p <). یافته های حاصل از این مطالعه اثرات تعدیل کنندگی عصاره دانه شاهی بر رفتارهای شبه افسردگی را نشان داد، اما این عصاره بر رفتارهای شبه اضطرابی اثرات معنی داری نداشت.

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