Usage of Phenytoin in Treatment of severe Headache in COVID-19 Patients
الموضوعات :
Hayder Alhemiary
1
,
Dhuha Almayoof
2
1 - M.B.Ch.B., F.I.C.M.S (Neurosurgery), Instructor, Baghdad Medical College, Consultant Neuro & Orbital Surgery, Medical City, Department of Neurosurgery, Iraq
2 - M.B.Ch.B., CABS, Specialized Radiology, Medical City, Alshahid Ghzi, Department of Radiology, Iraq
تاريخ الإرسال : 04 الأحد , ربيع الأول, 1443
تاريخ التأكيد : 02 السبت , شعبان, 1443
تاريخ الإصدار : 07 الخميس , جمادى الأولى, 1444
الکلمات المفتاحية:
Treatment,
Phenytoin,
Headache,
COVID-19,
ملخص المقالة :
COVID-19 is a viral infection transmitted through the respiratory system, caused by Coronavirus type 2 usually get excess to the body through Flügge microdroplet of an infected person to a healthy one with air although direct contact and aerosol may be another route for transmission. This is a prospective study of 500 patients (63% women) conducted in a medical city in Baghdad. In a study patients’ collection started in Aug 2020 for six weeks. They followed for at least six months after they recovered from COVID-19. Among 500 patients included 53.4% were male (out of those 118 were complain of severe headaches 23.6%), while females comprise about 46.6% of total patients of that 13% had severe headaches. The highest age group with severe headaches was (60-65) years coming next (51-55) years. group A had a partial response to drugs used although more than 60% respond to a combination of Ibuprofen and Acetaminophen, while in group B good control of Headache was achieved (80%) when adding Phenytoin to treatment protocol during and after the acute stage of the disease. There is controversy about the treatment of headaches caused by COVID-19 but for sure, Acetomenaphin combined with NSADI drugs is the best and safe choice. In refractory cases, antiepileptic drugs like phenytoin are added to achieve freedom of pain and for a long-term period.
المصادر:
Zhou M., Zhang X., Qu J., 2020. Coronavirus disease 2019 (COVID-19): a clinical update. Front Med. 14(2), 126-135.
Belvis R., 2020. Headaches during COVID-19: My Clinical Case and Review of the Literature. Headache. 60(7), 1422-1426.
COVID-19 and headaches: What you need to know Headache is often an early warning By Cliff Mehrtens.https://www.novanthealth.org/healthy-headlines/covid-19-and-headaches-what-you-need-to-know, November, 2, 2020.
COVID-19 and Headaches, By Dr. Osman Shabir, PhD https://www.news-medical.net/health/COVID-19-and-Headache.aspx.
Caronna E., Ballvé A., Llauradó A., Gallardo V.J., Ariton D.M., Lallana S., Lopez Maza S., Olive Gadea M., Quibus L., Restrepo J.L., Rodrigo-Gisbert M., 2020. Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia. 40(13), 1410-1421.
Pain Scale Chart: 1 to 10 Levels: Published: 2016-05-20 -Updated: 2020-03-12:https://www.disabled-world. com/ health/pain/scale.php.
MaassenVan Den Brink A., de Vries T., Danser A.H.J., 2020. Headache medication and the COVID-19 pandemic. J Headache Pain. 21(1), 38.
World Health Organization. https://www. who.int/ healthtopics /coronavirus#tab=tab_3 (2020, accessed 10 August 2020).
Hesselink J.M., Schatman M.E., 2017. Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment. Journal of Pain Research. 10, 1663.
Arca K.N., Smith J.H., Chiang C.C., Starling A.J., Robertson C.E., Halker Singh R.B., Schwedt T.J., Kissoon N.R., Garza I., Rozen T.D., Boes C.J, 2020. COVID‐19 and headache medicine: a narrative review of non‐steroidal anti‐inflammatory drug (NSAID) and corticosteroid use. Headache: The Journal of Head and Face Pain. 60(8), 1558-68.
Arca K.N., Starling A.J., 2020. Treatment-refractory headache in the setting of COVID-19 pneumonia: migraine or meningoencephalitis? Case report. SN Comprehensive Clinical Medicine. 2(8), 1200-3.
Morollón N., Belvís R., De Dios A., Pagès N., González-Oria C., Latorre G., Santos-Lasaosa S., 2020. Standard headache and neuralgia treatments and SARS-CoV-2: opinion of the Spanish Society of Neurology’s Headache Study Group. Neurología (English Edition). 35(9), 628-32.
MaassenVan Den Brink A., De Vries T., Danser A.J., 2020. Headache medication and the COVID-19 pandemic. The Journal of Headache and Pain. 21(1), 1-4.
