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عنوان URL للمقالة


رقم المقالة : 697643 زيارة : 238 الصفحة: 477 - 484

10.22034/jchr.2022.697643

نوع المخطوط: ابحاث

Seroprevalence of Toxoplasma gondii and Its Effect on the Levels of Dopamine and Adrenaline in Humans

الموضوعات :

Zahraa K. Mijbel 1 , Hussain A. Mhouse Alsaady 2

1 - Department of Biology, College of Science, University of Misan, Maysan, Iraq
2 - Department of Biology, College of Science, University of Misan, Maysan, Iraq

تاريخ الإرسال : 05 الخميس , صفر, 1444 تاريخ التأكيد : 15 الجمعة , جمادى الأولى, 1444 تاريخ الإصدار : 16 الجمعة , صفر, 1445

الکلمات المفتاحية: Toxoplasmosis, IgM, Dopamine, Seroprevalence IgG, Adrenaline, Maysan’ Iraq,

ملخص المقالة :

The current study was conducted in Maysan province, Southern Iraq. Blood samples were collected from 174 individuals (male and female), from December 2020 to May 2021. ELISA was used to calculate the seroprevalence of Toxoplasma gondii by determining the levels of anti-toxoplasma IgM and IgG, as well as the levels of dopamine and adrenaline in the participants' blood. The overall seroprevalence of toxoplasmosis in Amarah city is 52.3%. In regards to the seropositive cases, there is 32.97% positive to IgM, 38.46% is positive IgG, and 28.57% is positive to both IgM + IgG. The level mean of dopamine in toxoplasmosis-seropositive cases is 2.9543x10-2 mg ml-1, which is higher than that of negative cases (1.8086x10-2 mg ml-1). There are statistically significant differences (p<0.05) between the levels of dopamine in toxoplasmosis-seropositive and negative cases. The mean level of adrenaline in toxoplasmosis-seropositive cases is 2.8752x10-2 mg ml-1. Which is higher than that of negative cases (1.3670x10-2 mg ml-1), there is a statistically significant difference (p<0.05) between its levels in toxoplasmosis-seropositive and negative cases.

المصادر:


  1. Augusto L., Martynowicz J., Amin P.H., Alakhras N.S., Kaplan M. H., Wek R.C. and Sullivan W.J., 2020.Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells. Mbio. 11(4), e00915-20. DOI: 10.1128/mbio.00915-20.
    2.
  2. Lindsay D.S., Dubey J.P., 2020Toxoplasmosis in Wild and Domestic Animals. In: Toxoplasma Gondii, 3rd ed., Weiss L.M., Kim K., Eds., Academic Press, USA. pp. 239-320..
    3.
  3. Mose J.M., Kagira J.M., Kamau D.M., Maina N.W., Ngotho M., Karanja S.M., 2020. A Review on the Present Advances on Studies of Toxoplasmosis in Eastern Africa. Biomed Res Int. 6, 2020, 7135268. DOI: 10.1155/2020/7135268.
    4.
  4. CDC: Neglected Parasitic Infections in the United States-Toxoplasmosis. https://www .cdc.gov/parasites/ toxoplasmosis/npi_toxoplasmosis.html
    5.
  5. Rogério S.V., Patrícia R., Rosiane G.M., and Marco A.C., 2011. Congenital Toxoplasmosis: A Neglected Disease? -Current Brazilian public health policy. Field Actions Science Reports [Online]. 5(Special Issue 3),1-8, 2011, http://journals.openedition.org/factsreports/1086
    6.
  6. Almeria S. and Dubey J.P., 2021. Foodborne transmission of Toxoplasma gondii infection in the last decade. An overview. Res Vet Sci. 135,371-385. doi: 10.1016/j.rvsc.2020.10.019
    7.
  7. Robert-Gangneux F., Dardé M.L., 2012. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev. 25, 264-296.
    8.
  8. Dubey J.P., Jones J.L., 2008. Toxoplasma gondii Infection in Humans and Animals in the United States. International Journal for Parasitology. 38, 1257-1278. http://dx.doi.org/10.1016/j.ijpara.2008.03.007.
    9.
  9. AL-Mayahi J.R. Gzar (2011) Epidemiological Study on Toxoplasma gondii in aborted women in Kut city, MSc Thesis University of Baghdad, Iraq.
    10.
  10. Tenter A.M., Heckeroth A.R. and Weiss L.M., 2000. Toxoplasma gondii: From animals to humans. Int J Parasitol. 30(12-13), 1217-1258
    11.
  11. Khademi S.Z., Ghaffarifar F., Dalimi A., Davoodian P., and Abdoli A., 2019. Prevalence and Risk Factors of Toxoplasma gondii Infection among Pregnant Women in Hormozgan Province, South of Iran. Iran J Parasitol. 14(1), 167-173.
    12.
  12. Behbehani K., Al-Karmi T., 1980. Epidemiology of toxoplasmosis in Kuwait. I. Detection of antibodies to Toxoplasma gondii and percentage distribution among the inhabitants. Transactions of the Royal Society of Tropical Medicine and Hygiene. 74(2), 209-212.
    13.
  13. Makiani M.J., Davoodian P., Golsha R., Dehghani M., Rajaee M., Mahoori K., Qasemi S., Alavi A., Ghashghyizadeh N., Eftekhari S.T. and Heidari M., 2012. Seroepidemiology and risk factors of toxoplasmosis in the first trimester among pregnant women. Int Elec J Med. 1, 12-17.
    14.
  14. Bigna J.J., Tochie J.N., Tounouga D.N., Bekolo A.O., Ymele N.S., Youda E.L., Sime P.S., Nansseu J.R., 2020. Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modeling and meta-analysis. Sci Rep. 10, 12102. https://doi.org/10.1038/s41598-020-69078
    15.
  15. Mulugeta S., Munshea A., Nibret E., 2020. Seroprevalence of Anti–Toxoplasma gondii antibodies and associated factors among pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia. Infectious Diseases: Research and Treatment. 2020, 13. https://doi. org/10. 1177/ 1178633720948872
    16.
  16. Alsaady H.A.M., Al-Abboodi A., Abood S., 2021. Seroepidemiology of Toxoplasma gondii among men and pregnant women in Maysan Province, South of Iraq. Iranian Journal of Ichthyology. 8, 27-37.
    17.
  17. Robinson C.M., O’Dee D., Hamilton T., Nau G.J., 2009. Cytokines involved in interferon- gamma production by human macrophages. J Inn Immunol. 2(1), 56-65.
    18.
  18. Mahmud R., Lim Y.A.L., Amir A., 2017. Medical Parasitology. Springer International Publishing, Switzerland. pp. 53-58. https://doi.org/10.1007/978-3-319-68795-7_7
    19.
  19. Naot Y., Guptil D.R. and Remington J., 1982. Duration of IgM antibodies to Toxoplasma gondii after acute acquired toxoplasmosis. J Infect Dis. 145(5), 77.
    20.
  20. Marcolino P.T., Silva A.O., Leser P.G., Camargo M.E. and Mineo J.R., 2000. Molecular Markers in Acute and Chronic Phases of Human Toxoplasmosis: Determination of Immunoglobulin G Avidity by Western Blotting. Clinical and Diagnostic Laboratory Immunology. 7(3), 384-389.
    21.
  21. Hester J., Mullins J.S., Payne L., Mercier C., Cesbron-Delauw F., Suzuki Y., 2012. Toxoplasma gondii Antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection. Infection and Immunity. 80(10), 3611-3620.
    22.
  22. Ybañez R.H.D., Ybañez A.P., Nishikawa Y., 2020. Toxoplasma gondii, Serodiagnosis, recombinant antigens, Toxoplasmosis, human. Frontiers in Cellular and Infection Microbiology. 10, 3389/fcimb. 2020.00204.
    23.
  23. Villard O., Cimon B., L'Ollivier C., Fricker-Hidalgo H., Godineau N., Houze S., Paris L., Pelloux H., Villena I., Candolfi E., 2016. Serological diagnosis of Toxoplasma gondii infection: Recommendations from the French National Reference Center for Toxoplasmosis. Diagn Microbiol Infect Dis. 84(1), 22-33.
    24.
  24. Song Y., Zhao Y., Pan K., Shen B., Fang R., Hu M., Zhao J., Zhou Y., 2021. Characterization and evaluation of a recombinant multiepitope peptide antigen MAG in the serological diagnosis of Toxoplasma gondii infection in pigs. Parasites Vectors. 14, 408.
    25.
  25. Pishkari S., Shojaee S., Keshavarz H., Salimi M., Mohebali M., 2017. Evaluation of Toxoplasma gondii soluble, whole and excretory/secretary antigens for diagnosis of toxoplasmosis by ELISA test. J Parasit Dis. 41, 289–91.
    26.
  26. Alhajj M., Farhana A., 2022. Enzyme Linked Immunosorbent Assay. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, Jan, 2022. https://www.ncbi.nlm.nih.gov/books/NBK555922/.
    27.
  27. Berridge K.C., 2007. "The debate over dopamine's role in reward: the case for incentive salience". Psychopharmacology. 191(3), 391-431.
    28.
  28. Schacter D., Gilbert D., Nock M., Wegner D., 2020. Psychology. 5th ed., Worth Publisher, Macmillan, New York, USA.
    29.
  29. Cannon W.B. Rosenblueth A., 1935. A comparative study of sympathin and adrenine. Am. J. of Physiology-Legacy Content. 112(2), 268-276.
    30.
  30. Lieberman M., Marks A., Peet A., 2013. Marks' Basic Medical Biochemistry: A Clinical Approach, 4th ed., Wolters Kluwer Health/Lippincott Williams and Wilkins, pp. 175.
    31.
  31. Brown H.F., DiFrancesco D., Noble S.J., 1979. How does adrenaline accelerate the heart? Nature. 280, 235-236.
    32.
  32. Goldstein D.S., 1999. Clinical Pharmacology of The Autonomic Nervous System In: Handbook of Clinical Neurology: The Autonomic Nervous System, Part I, Appenzeller O. ed., Vol. 74 Elsevier: Amsterdam. pp. 135–179.
    33.
  33. Westfall T.C., Westfall D.P., 2011. Adrenergic agonists and antagonists In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 12th ed., Brunton L.L., Ed. McGraw‐Hill: New York. pp. 277–333.
    34.
  34. Verberne A.J.M., Korim W.S., Sabetghadam A., 2016. Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetes. British Journal of Pharmacology. 173(9), 1425-1437.
    35.
  35. Bell D.R., 2009. Medical Physiology: Principles for Clinical Medicine, 3rd ed., Lippincott Williams and Wilkins: pp. 312.
    36.
  36. Boillat M., Hammoudi P., Dogga S., Pagès S., Goubran M., Rodriguez I., Soldati-Favre D., 2020. Neuroinflammation-associated a specific manipulation of mouse predator fear by Toxoplasma gondii. Cell Rep. 30(2), 320-334.
    37.
  37. Lindová J., Příplatová L. and Flegr J., 2012. Higher extraversion and lower conscientiousness in humans infected with Toxoplasma. Eur J Personal. 26(3), 285–291.
    38.
  38. Webster J.P., Kaushik M., Bristow G.C., McConkey G.A., 2013. Toxoplasma gondii infection from predation to schizophrenia: can animal behaviour help us understand human behaviour? J Exp Biol. 216, 99-112.
    39.
  39. Cabral C.M., Tuladhar S., Dietrich H.K., Nguyen E., MacDonald W.R., Trivedi T., Devineni A., Koshy A.A., 2016. Neurons are the primary target cell for the brain-tropic intracellular parasite Toxoplasma gondii. PLoS. Pathog. 12(2), e1005447.
    40.
  40. Parlog A., Schluter D. and Dunay I.R., 2015. Toxoplasma gondii - induced neuronal alterations. Parasite Immunology. 37, 159–170.
    41.
  41. Skallová A., Kodym P., Frynta D., Flegr J., 2006. The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study. Parasitology. 133(5), 525-35.
    42.
  42. Prandovszky E., Gaskell E., Martin H., Dubey J.P., Webster J.P., McConkey G.A., 2011. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS ONE. 6, e23866.
    43.
  43. Pappas G., Roussos N., Falagas M.E. 2009. Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol. 39, 1385–1394. https://doi.org/10.1016/j.ijpara.2009.04.003
    44.
  44. Ðakovic-Rode O., Židovec-Lepej S., Vodnica Martucci M., Lasica Polanda V. and Begovac J., 2010. Prevalence of antibodies against Toxoplasma gondii in patients infected with human immunodeficiency virus in Croatia. Croat J Infect. 30, 5–10.
    45.
  45. Elsheikha H.M., Azab M.S., Abousamra N.K., Rahbar M.H., Elghannam D.M., Raafat D., 2009. Seroprevalence of and risk factors for Toxoplasma gondii antibodies among asymptomatic blood donors in Egypt. Parasitol Res. 104, 1471-1476.
    46.
  46. Almasian R., Almasian M., Zibaei M., 2014. Sero-epidemiology of toxoplasmosis among the people of Khorram Abad, Iran. J Infect Dis Ther. 2, 159.
    47.
  47. Bobic B., Nikolic A., Klun I., Vujanic M., Djurkovic-Djakovic O., 2007. Undercooked meat consumption remains the major risk factor for Toxoplasma infection in Serbia. Parassitologia. 49, 227-230.
    48.
  48. Stopic M., Štajner T., Markovic-Denic L., Nikolic V., Djilas I., Srzentic S.J., Djurkovic-Djakovic O., Bobic B., 2022. Epidemiology of Toxoplasmosis in SERBIA: A Cross-Sectional Study on Blood Donors. Microorganisms. 10, 492, https:// doi.org/10 .3390/microorganisms1003049
    49.
  49. Yacoub A.A.H., Bakr S., Hameed A.M., Al Thamery A.A.A., Fartoci M.J., 2006. Seroepidemiology of selected zoonotic infections in Basra region of Iraq. EMHJ-Eastern Mediterranean Health J. 12(1-2), 112-118.
    50.
  50. Al-Sadoon M.A., Nasir M.A., Yasir E.T., Khalaf A.O. and Kadim S.J., 2018. Toxoplasmosis and risk factors among female students of medical colleges at Basra University, Iraq. Biomedical and Pharmacology J. 11(4), 2117-2122.
    51.
  51. Hadi H.S., Kadhim R.A., Al-Mammori R.T., 2016. Seroepidemiological aspects for Toxoplasma gondii infection in women of Qadisiyah province, Iraq. Int J Pharm Tech Res. 9(11), 252-259.
    52.
  52. Al-Sray A.H., Sarhan S.R., Mohammed H.A., 2019. Molecular and serological characterization of Toxoplasma gondii in women in Wasit province. Advances in Animal and Veterinary Sciences. 7(8), 657-663.
    53.
  53. Hussein N., Balatay A.A., 2019. The seroprevalence of Toxoplasma, Cytomegalovirus and Rubella infections in women with abortion in Kurdistan Region of Iraq: A brief report. International Journal of Infection. 6(1), e86734. DOI: 10.5812/iji.86734.
    54.
  54. Yan C., Liang L.J., Zheng K.Y., Zhu X.Q., 2016. Impact of environmental factors on the emergence, transmission and distribution of Toxoplasma gondii. Parasit Vectors, 9.137, doi: 10.1186/s13071-016-1432-6.
    55.
  55. Kaňková Š. and Flegr J., 2007. Longer pregnancy and slower fetal development in women with latent" asymptomatic" toxoplasmosis. BMC Infectious Diseases. 7(1), 1-7.
    56.
  56. Wilking H., Thamm M., Stark K., Aebischer T., Seeber F., 2016. Prevalence, incidence estimations and risk factors of Toxoplasma gondii infection in Germany: a representative, cross-sectional, serological study. Scientific Reports. 6(1), 1-9.
    57.
  57. Flegr J., Kaňková Š., 2020. The effects of toxoplasmosis on sex ratio at birth. Early Human Development. 141, 104874.
    58.
  58. Al-Aboody B.A., 2015. Prevalence Study of Toxoplasmosis among Males Blood Donors in Thi-Qar province, Iraq. M.Sc. Thesis. College of Science University of Thi Qar, Iraq.
    59.
  59. Darweesh N.H., Hussein R.A., Salman S.T., Shaker M.J., 2018. Immunological and Molecular study of Toxoplasma gondii from aborted women in Diyala/Iraq. J. Ilam Uni Med Sci., 2(6), 75-82
    60.
  60. Stibbs H.H., 1985. Changes in brain concentrations of catecholamines and indole amines in Toxoplasma gondii infected mice. Ann Trop Med Parasitol. 79, 153-157.
    61.
  61. McConkey G.A., Martin H.L., Bristow G.C., Webster J.P., 2013. Toxoplasma gondii infection and behaviour-location, location, location? J Exp Biol. 216, 113-119.
    62.
  62. Al-Hadad M.T.S., Kadhim R.A., Al-Rubaye A.F., 2019. Effect of chronic Toxoplasmosis on levels of some neurotransmitters (Dopamine, Adrenaline, and Noradrenaline) in human serum. J. Pharmaceutical Sciences and Research. 11(2), 402-405.
    63.
  63. Ibrahim A.M., Abdel Gawad M.I.M., Abd-Elftah A.A.G., Abdel-Latif M., Mohamed S.R., Salah H., Sayed A.G.S., Abu-Sarea E.Y., 2020. Toxoplasmosis in schizophrenic patients: Immune-diagnosis and serum dopamine level. Pak J Biol Sci., 23(9), 1131-1137.
    64.
  64. Mirzaeipour M., Mikaeili F., Asgari Q., Nohtani M., Rashidi S., and Bahreini, M.S., 2021. Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis. J Parasitolo Res. 2021(5), 1-9.
    65.
  65. Omidian M., Asgari Q., Bahreini M.S., Moshki S., Sedaghat B., Adnani Sadati S.J., 2022. Acute toxoplasmosis can increase serum dopamine level. J Parasit Dis. 46(2), 337-342.
    66.
  66. Best J.A., Nijhout H.F., Reed M.C., 2009. Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. Theoretical Biology and Medical Modelling. 6, 21. https://doi.org/10.1186/1742-4682-6-21
    67.
  67. Gaskell E.A., Smith J.E., Pinney J.W., Westhead D.R., McConkey G.A., 2009. A unique dual activity amino acid hydroxylase in Toxoplasma gondii. PLoS ONE. 4(3), e4801. https:// doi.org /10.1371/ journal.pone.000480
    68.
  68. Wang X., Li J., Dong G., and Yue J., 2014. "The endogenous substrates of brain CYP2D". European Journal of Pharmacology. 724, 211-218.
    69.
  69. Kadhim R.A. and Al-Awadi H.M., 2013. Seroprevalence of Toxoplasma gondii antibodies among pregnant women in Babylon province, Iraq. Kufa Journal for Nursing Sciences. 3(3), 153-159.
    70.
  70. Cosentino M., and Marino F., Nerve Driven Immunity: Noradrenaline and Adrenaline. In: Nerve-Driven Immunity, Levite, M., Ed. Springer, Vienna, 2012. pp. 47–96. https://doi.org/10.1007/978-3-7091-0888-8_2
    71.

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