Low Serum Potassium Level and Its Effects on the Severity and the Rate of Hospitalization in Asthmatic Adults

الموضوعات :

W. J. Majid ¹ (Department of Biochemistry, College of Medicine, University of Thi-Qar, Iraq)
Hanaa S. Khadem ² (Department of Biology, College of Science, University of Basrah, Iraq)
Tayseer A. Talab ³ (Department of Pharmacology, College of Medicine, University of Thi-Qar, Iraq)
, Mahdi M. Thuwaini ⁴ (College of Medical and Healthy Techniques- Southern Technical University, Iraq)

تاريخ الإرسال : 23 الأربعاء , رمضان, 1442 تاريخ التأكيد : 20 الخميس , ربيع الثاني, 1443 تاريخ الإصدار : 12 الخميس , ذو القعدة, 1444

الکلمات المفتاحية: Asthma, Potassium, Hypokalemia, Lung,

ملخص المقالة :

Bronchial asthma is a prevalent issue with significant medical and economic repercussions. Potassium (K) unbalance is associated with airway hyperreactivity, wheezing, and lung function impairment. Forty patients suffering from bronchial asthma, with regular follow-ups in an asthma clinic of the General Qurna Hospital, were investigated in this study. Each individual was questioned and evaluated clinically. Serum (K+) concentration and asthma severity were measured. The used drugs were documented. The total number of hospitalizations owing to asthma exacerbation was determined for the six months preceding the day of testing serum (K+) level. Nineteen patients (48%) had low K+ levels with a mean of 1.52 ±0.92 mmol L-1, while 21 patients (52%) had normal K levels (4.3±0.21 mmol L-1) (P<0.05). The study found that hypokalemia was common in younger patients (mean aged 22.5±1.3 years) Asthmatics females tend to have a significant of hypokalemia than males (58%) (P<0.05).

المصادر:

1. Urso D.L., 2009. Asthma in the elderly. Current gerontology and geriatrics research. 2009.


2. Kitch B.T., Levy B.D., Fanta C.H., 2000. Late onset asthma. Drugs & aging. 17(5), 385-397.


3. Enright P.L., Mc Clelland R.L., Newman A.B., Gottlieb D.J., Lebowitz M.D., for the Cardiovascular Health Study Research Group, 1999. Underdiagnosis and undertreatment of asthma in the elderly. Chest. 116(3), 603-613.


4. Moorman J.E., Moorman J., Mannino D.M., 2001. Increasing US asthma mortality rates: who is really dying? Journal of Asthma. 38(1), 65-71.


5. Abernathy R.P., Black D.R., 1996. Healthy body weights: an alternative perspective. Am J Clin Nutr. 63(3 Suppl), 448-451.


6. Haalboom J.R.E., Deenstra M., Struyvenber A., 1985. Hypokalaemia induced by inhalation of fenoterol. The Lancet. 325(8438), 1125-1127.


7. Rolla G., Bucca C., 1989. Hypomagnesemia and bronchial hyperreactivity: a case report. Allergy. 44(7), 519-521.


8. Falkner D., Glauser J., Allen M., 1992. Serum magnesium levels in asthmatic patients during acute exacerbations of asthma. The American Journal of Emergency Medicine. 10(1), 1-3.


9. Mohammad H.A., Abdulfttah M.T., Abdulazez A.O., Mahmoud A.M., Emam R.M., 2014. A study of electrolyte disturbances in patients with chronic stable asthma and with asthma attacks. Egyptian Journal of Chest Diseases and Tuberculosis. 63(3), 529-534.


10. Alamoudi O.S., 2000. Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization. European Respiratory Journal. 16(3), 427-431.


11. Murlas C., Ehring G.E.O.R.G.E., Suszkiw J., Sperelakis N.I.C.H.O.L.A.S., 1986. K⁺-induced alterations in airway muscle responsiveness to electrical field stimulation. Journal of Applied Physiology. 61(1), 61-67.


12. Okayama H., Aikawa T., Okayama M., Sasaki H., Mue S., Takishima T., 1987. Bronchodilating effect of intravenous magnesium sulfate in bronchial asthma. Jama. 257(8), 1076-1078.


13. Spivey W.H., Skobeloff E.M., Levin R.M., 1990. Effect of magnesium chloride on rabbit bronchial smooth muscle.  Annals of Emergency Medicine. 19(10), 1107-1112.


14. Gugger M.A.T.T.H.I.A.S., 1989. Changes in serum potassium concentration in asthmatic and normal subjects during exercise. Thorax. 44(7), 605-606.


15. Emelyanov A., Fedoseev G., Barnes P.J., 1999. Reduced intracellular magnesium concentrations in asthmatic patients. European Respiratory Journal. 13(1), 38-40.


16. Howard J.F., 1990. Adverse drug effects on neuromuscular transmission. In Seminars in Neurology. 10(1), 89-102. 1990 by Thieme Medical Publishers, Inc.


17. Emelyanov A., Fedoseev G., Barnes P.J., 1999. Reduced intracellular magnesium concentrations in asthmatic patients. European Respiratory Journal. 13(1), 38-40.


18. Kass R.S., Lederer W.J., Tsien R.W., Weingart R., 1978. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. The Journal of Physiology. 281(1), 187-208.


19. Barnes P.J., 1989. A new approach to the treatment of asthma. New England Journal of Medicine. 321(22), 1517-1527.


20. Alamoudi O.S., 2001. Electrolyte disturbances in patients with chronic, stable asthma: effect of therapy. Chest. 120(2), 431-436.


21. Enright P.L., 2002. The diagnosis and management of asthma is much tougher in older patients. Current Opinion in Allergy and Clinical Immunology. 2(3), 175-181.