Overexpression of TRIM37 is Associated with Unfavorable Outcomes in Gastric Cancer Patients

الموضوعات :

Jalil Afshar ¹ , Jamshid Mehrzad ² , Hassan Mehrad-Majd ³ , Jafar Saeidi ⁴

1 - Department of Biochemistry, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2 - Department of Biochemistry, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
3 - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 - Department of Physiology, School of Basic Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran

تاريخ الإرسال : 26 الأربعاء , ربيع الأول, 1445 تاريخ التأكيد : 03 الأربعاء , جمادى الثانية, 1446 تاريخ الإصدار : 16 الثلاثاء , صفر, 1446

الکلمات المفتاحية: gastric cancer, Survival, β-catenin, TRIM37, Prognostic factor,

ملخص المقالة :

TRIM37 expression has been shown to be dysregulated in various types of cancers. This study was aimed to assess the clinical significance and potential utility of TRIM37 expression level as an indicator of prognosis in gastric cancer (GC) patients. The potential correlation between TRIM37 and the levels of β-catenin, Cyclin D and BCL2 was also investigated. qRT-PCR was used to determine the expression levels of TRIM37 in 40 fresh GC and their adjacent noncancerous tissues. Statistical analyses were conducted to evaluate the relationship between TRIM37 expression levels, overall survival (OS), various clinicopathological features, and the expression levels of β-catenin, Cyclin D, and Bcl-2. TRIM37 expression was significantly higher in the cancerous tissue samples compared to noncancerous tissues (Fold change=1.92, P=0.007). Moreover, Kaplan-Meier analysis indicated that high TRIM37 group exhibited shorter OS (P=0.003). TRIM37 overexpression was strongly associated with poor prognosis and predicts unfavorable outcomes in GC patients (HR=1.85, 95%CI: 1.28-2.66, P=0.001). A direct correlation was also observed between TRIM37 and elevated levels of β-catenin, a gene known for its role in cell proliferation among GC patients. TRIM37 overexpression is strongly linked with a poor prognosis in GC patients, highlighting its potential as an independent prognostic factor in GC and providing insight into its possible involvement in cancer development through Wnt/β-catenin signaling pathway. However, additional research is required to validate the potential prognostic value of TRIM37 in gastric cancer.

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