Correlation of High Dose of Vitamin D₃ with Increased Hemoglobin in Patients under Mechanical Ventilation in Medical ICU

الموضوعات :

Saraa Salarian ¹ , Seyed Pouzhia Shojaei ² , Mehran Kouchek ³ , Mir Mohammad Miri ⁴ , Mohammad Sistanizad ⁵ , Amin Sahranavard ^{6 *} , Tahere Sorbi ⁷

1 - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 - Anesthesia and Critical Care Department, Critical Care Quality Improvement Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 - Anesthesia and Critical Care Department, Critical Care Quality Improvement Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 - Anesthesia and Critical Care Department, Critical Care Quality Improvement Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 - Anesthesia and Critical Care Department, Critical Care Quality Improvement Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 - Anesthesiology Research Center, Iran University of Medical Sciences, Tehran, Iran

تاريخ الإرسال : 08 الثلاثاء , شعبان, 1444 تاريخ التأكيد : 09 الإثنين , شعبان, 1445 تاريخ الإصدار : 21 السبت , شوال, 1446

الکلمات المفتاحية: Vitamin D₃, Hemoglobin concentration, Mechanical ventilation,

ملخص المقالة :

Anemia is very common in critical illnesses. Around two-thirds of adults are anemic when admitted to the intensive care unit (ICU). Recently, Vitamin D deficiency has been identified as a potential cause of inflammatory anemia. In this study, we examine the relationship between the injection of a high dose of vitamin D₃ and the hemoglobin level in patients undergoing mechanical ventilation in the ICU unit. The present study is a double-blind clinical trial. During a six-month period (June to November 2018), all patients admitted to the ICU department of Imam Hossein Hospital who met the study's inclusion criteria and were under mechanical ventilation were randomly divided into two groups. At first, the concentration of hemoglobin and the level of vitamin D₃ were checked. In the control group, a placebo was used, while in the intervention group, patients were administered vitamin D3 via gavage (50,000 units for 5 days). The hemoglobin levels were measured and recorded once a week for a maximum duration of one month. No statistically significant difference was observed between the two groups in terms of demographic variables and SOFA. The average hemoglobin levels before and after the study in the vitamin D₃ group were 9.9 ± 2.1 and 11.2 ± 2.5, respectively, and the difference was statistically significant (P=0.004). While in the control group, the average hemoglobin levels before and after the study were 9.9 ± 2.1 and 10.2 ± 1.8, respectively. However, the difference was not found to be statistically significant (P=0.102). In this study, it was found that increasing the level of vitamin D₃ in patients hospitalized for 6 months in the ICU significantly increased their hemoglobin levels.

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