Fractionation and In vitro Evaluation of Prunus persica Pulp Extract against Urolithasis
الموضوعات :
Hema Arya
1
,
Gautam Kumar
2
,
Vandana .
3
,
Minakshi Pandey
4
1 - Department of Pharmacy, Sharda University, Knowledge Park III, Greater Noida-201310, Uttar Pradesh, India
2 - Department of Pharmacy, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, India.
3 - Department of Pharmacy, Sharda University, Knowledge Park III, Sharda University, Greater Noida, Uttar Pradesh, India.
4 - Department of Pharmacy, Sharda University, Knowledge Park III, Sharda University, Greater Noida, Uttar Pradesh, India.
الکلمات المفتاحية: Prunus persica, Kidney stones, Urolithiasis, Phyto-pharmaceuticals, Fractions of extract,
ملخص المقالة :
The peach tree “Prunus persica” is widely cultivated in India, and its fruits which have been used for centuries in traditional Indian medicine, are also known as the Queen of the Fruits. Prunus persica has immense therapeutic potential, widespread use in folklore and ancient systems of medicine for its anti-urolithic and other medicinal properties, and is included in the Pashanbheda group of herbs mentioned in Ayurveda for the treatment of kidney stones. Moreover, with growing interest in phytopharmaceuticals in the present world, there always remains an urge for a comprehensive understanding of the phytochemicals responsible for the medicinal activity of herbal drugs, giving rise to the importance of conducting bioassay-guided fractionation. In this study, the anti-urolithiasis activity of different fractions of Prunus persica fruit extracts was evaluated via Nucleation, Aggregation, and Growth assays, and fraction III showed the highest effects in vitro. This study provides a pharmacological basis for using Prunus persica fruit extract in treating kidney stones.
1. Al-Mayali Z.K., Jaffat H.S., Mohammed J.A., 2019. Effect of the indomethacin drug on kidney histology in male Albino Rats. Int J pharm Quality Assurance. 10(3), 162-167.
2. Lind M., Pivodic A., Svensson A.M., Ólafsdóttir A.F., Wedel H., Ludvigsson J., 2019. HbA1c level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: Swedish population-based cohort study. BMJ (Clinical research ed.). 366, l4894.
3. Wang Z., Zhang Y., Zhang J., Deng Q., Liang H., 2021. Recent Advances on the Mechanisms of Kidney Stone Formation (Review). International Journal of Molecular Medicine. 48(2), 149.
4. Zeng G., Mai Z., Xia S., Wang Z., Zhang K., Wang L., Long Y., Ma J., Li Y., Wan S.P., Wu W., Liu Y., Cui Z., Zhao Z., Qin J., Zeng T., Liu Y., Duan X., Mai X., Yang Z., Kong Z., Zhang T., Cai C., Shao Y., Yue Z., Li S., Ding J., Tang S., Ye Z., 2017. Prevalence of Kidney Stones in China: An Ultrasonography Based Cross-Sectional Study. BJU International. 120(1), 109–16.
5. Eisner B.H., Goldfarb D.S., 2014. A Nomogram for the Prediction of Kidney Stone Recurrence. Journal of the American Society of Nephrology. 25(12), 2685.
6. Alelign T., Petros B., 2018. Kidney Stone Disease: An Update on Current Concepts. Advances in Urology. 2018, 3068365.
7. Barbas C., Garcıa A., Saavedra L., Muros M., 2002. Urinary Analysis of Nephrolithiasis Markers. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 781(1–2), 433–55.
8. Ekor M., 2014. The Growing Use of Herbal Medicines: Issues Relating to Adverse Reactions and Challenges in Monitoring Safety. Frontiers in Pharmacology. 4, 177.
9. Li Y., Wang L., 2020. Genetic Resources, Breeding Programs in China, and Gene Mining of Peach: A Review. Horticultural Plant Journal. 6(4), 205–15.
10. Rudke C.R.M., Zielinski A.A.F., Ferreira S.R.S., 2023. From Biorefinery to Food Product Design: Peach (Prunus Persica) By-Products Deserve Attention. Food and Bioprocess Technology. 16(6), 1197.
11. Nalini R., Anuradha R., 2017. Phytochemical Screening and Fluorescence Analysis of Methanolic Flower Extracts of Punica Granatum L. Scholars Academic Journal of Pharmacy. 6(9), 378–82.
12. Mushtaq A., Akbar S., Zargar M.A., Wali A.F., Malik A.H., Dar M.Y., Hamid R., Ganai B.A. 2014. Phytochemical screening, physicochemical properties, acute toxicity testing and screening of hypoglycaemic activity of extracts of Eremurus himalaicus baker in normoglycaemic Wistar strain albino rats. BioMed research international. 2014, 867547.
13. Phuyal N., Jha P.K., Raturi, P.P., Rajbhandary S., 2020. Total Phenolic, Flavonoid Contents, and Antioxidant Activities of Fruit, Seed, and Bark Extracts of Zanthoxylum Armatum DC. Scientific World Journal. 2020, 8780704.
14. Siddiqui N., Rauf A., Latif A., Mahmood Z., 2017. Spectrophotometric Determination of the Total Phenolic Content, Spectral and Fluorescence Study of the Herbal Unani Drug Gul-e-Zoofa (Nepeta Bracteata Benth). Journal of Taibah University Medical Sciences. 12(4), 360.
15. Biswal B., Susanta K.P., 2022. Pharmacognostical, Hepatoprotective and Anthelmintic Evaluation of Cuscuta Reflexa Roxb. and Gymnema Sylvestre (RETZ.) Rz BR. EX. SM. International Journal of Drug Delivery Technology. 12(02), 516–21.
16. Hewagama S.P., Ruwani P.H., 2022. Antiurolithiatic Potential of Three Sri Lankan Medicinal Plants by the Inhibition of Nucleation, Growth, and Aggregation of Calcium Oxalate Crystals In Vitro. The Scientific World Journal. 2022, 8657249.
17. Saha S., Ramtej J.V., 2013. Inhibition of Calcium Oxalate Crystallisation in Vitro by an Extract of Bergenia Ciliata. Arab Journal of Urology. 11(2), 187.
18. Mosquera D.M.G., Yannarys H.O., Pedro C.Q., Rafael S.M., Luc P., 2020. Antiurolithiatic Activity of Boldoa Purpurascens Aqueous Extract: An in Vitro and in Vivo Study. Journal of Ethnopharmacology. 253, 112691.
19. Bawari S., Archana N.S., Devesh T., 2018. Antiurolithiatic Activity of Daucus Carota: An In vitro Study. Pharmacognosy Journal. 10(5), 880–84.
