Evaluation of Blood Components of Glycemic Control in Diabetics with and without Cataract in Comparison with Non-diabetics

الموضوعات :

Elham Zainalinia ¹ , Rouhallah Najjar Sadeghi ² , Mostafa Ebadi ³ , Mohammad Faghihi ⁴

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Clinical Biochemistry, faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
4 - Department of Medical Sciences of Shahid Beheshti University, Surgeon and Ophthalmologist of Tehran, Iran

تاريخ الإرسال : 24 الجمعة , رجب, 1443 تاريخ التأكيد : 07 الأحد , رجب, 1444 تاريخ الإصدار : 17 الجمعة , جمادى الأولى, 1445

الکلمات المفتاحية: Diabetes, Cataract, OGTT, Fasting Plasma Glucose, Hemoglobin A1c,

ملخص المقالة :

Cataract is a leading cause of vision loss in the world. Several factors are involved in the development of cataracts, of them; diabetes and uncontrolled plasma glucose have great importance. Therefore, controlling glycemic reduces the risk of related to microvascular complications of diabetes diseases such as cataract. This study aimed to compare fasting plasma glucose (FPG), HgbA1c, and oral glucose tolerance test (OGTT) between Diabetic patients with and without cataract in comparison with the healthy group as control. Among 150 subjects, 50 diabetic patients, 50 diabetic cataracts, and 50 healthy individuals without a history of specific disease were compared with each other. Fasting plasma glucose, OGTT, and HgbA1c were measured by colorimetric methods. SPSS23 software was used to analyze data. P-values ​​less than 5% or lower were considered to be statistically significant. In this study, the mean fasting plasma glucose, HgbA1c, and OGTT in the group of diabetic patients, diabetic with cataract, and healthy groups fasting plasma glucose were as follow, 162.46 mg dL-1 and 184.76 mg dL-1, 92.88 mg dL-1 (P˂0.05), HgbA1c: 7.8, 8.0, 5.8% (P˂0.05) and OGTT: 228 mg dL-1, 246.12 mg dL-1 and 114.32 mg dL-1 (P˂0.05) respectively. Our findings showed that in diabetic patients with and without cataract, fasting plasma levels, HgbA1C, and OGTT are higher than the healthy group. There was a significant relationship between the studied factors and cataracts. As a result, high blood glucose has a definitive role in the development of cataracts.

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