Synthesis, Anti-bacterial and Anti-fungal evaluation of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4 yl)acrylamide

الموضوعات : Journal of the Iranian Chemical Research

Pravinkumar M. Patel ¹ , Ashvin D. Panchal ²

1 - Industrial Chemistry Department, Science College, Vallabh Vidyangar, Gujarat, India
2 - Industrial Chemistry Department, Science College, Vallabh Vidyangar, Gujarat, India

تاريخ الإرسال : 25 الأحد , ربيع الثاني, 1433 تاريخ التأكيد : 01 الجمعة , رمضان, 1433 تاريخ الإصدار : 04 الخميس , ذو القعدة, 1433

الکلمات المفتاحية: Antifungal, Antibacterial, triazole, Chalcone,

ملخص المقالة :

The Series of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by Claisen-Schmidt Condensation reactionwith different aromatic aldehydes. The structures of new compounds were confirmed by IR, 1H-NMR and13C-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with thestandard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activitycompared to standard drugs.

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