Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

الموضوعات : Journal of the Iranian Chemical Research

Abdolhassan Doulah ¹ (Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz 6134968875, Iran)
Masoud Mirzaei ² (Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad, 91775-1436, Iran)
Mohsen Nikpour ³ (Department of Chemistry, School of Sciences, Islamic Azad University, Ahvaz Branch, Ahvaz, 6134968875, Iran)
Yaghoub Farbood ⁴ (Physiology Research Center and Department Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran)

تاريخ الإرسال : 30 الخميس , صفر, 1432 تاريخ التأكيد : 20 الجمعة , ربيع الثاني, 1432 تاريخ الإصدار : 26 الخميس , ربيع الثاني, 1432

الکلمات المفتاحية: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine, Dimethylthio carbamoylchloride, pyrimidothiadiazine, Cyclocondensation,

ملخص المقالة :

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.

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