Antiplasmodial ativity of akaloids from Garcinia Parvifolia Miq. Stem Bark

الموضوعات : Journal of the Iranian Chemical Research

U.Z. Lathifah ¹ , R.A. Rahima ² , H. Sudrajat ³ , S. Khairi ⁴

1 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
2 - Advance Medical & Dental Institute, Suite 121, EUREKA Complex,Universiti Sains Malaysia, Minden 11800, Penang, Malaysia
3 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia
4 - Ikatan Mahasiswa Eksakta Indonesia, Barek, Sleman 55281, Yogyakarta, Indonesia

تاريخ الإرسال : 05 الإثنين , شعبان, 1430 تاريخ التأكيد : 15 الثلاثاء , ذو القعدة, 1430 تاريخ الإصدار : 25 الجمعة , محرم, 1432

الکلمات المفتاحية: Isoquinoline alkaloids, Garcinia Parvifolia Miq, Antiplasmodial,

ملخص المقالة :

Garciniavalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids,cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), wereisolated and characterized from Garcinia Parvifolia Miq. stem bark. Structural elucidation ofthese compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4)exhibited antiplasmodial activity against Plasmodium falciparum

المصادر:

[1] S. Jones, Morphology and Major Taxonomy of Garcinia (Guttiferae). Ph.D. dissertation, University
of Leicester and British Museum, London, 1980.
[2] P.W. Grasvenol, A. Supriono, D.A. Gray, J. Ethnopharmacol. 45 (1995) 97-111.
[3] K. Likhitwitayawuit, T. Phadungcharoen, J. Krungkrai, Planta Med. 64 (1998) 70-72.
[4] A.E. Hay, J. Helesbeux, O. Duval, M. Lay, P. Grellier, P. Richomne, Life Sci. 75 (2004) 3077-3085.
[5] M. Linuma, H. Tosa, R. Tanaka, F. Shimano, T. Asai, Y. Shigetomo, Phytochemistry. 35 (1994)
1355-1360.
[6] Likhitwitayawuit, W. Chamahasathien, N. Ruangrungsi, J. Krungkrai, Planta Med. 64 (1998) 281-
182.
[7] M.M. Mackeen, A.M. Ali, N.H. Lajis, K. Kawazu, Z. Hassan, M. Amran, M. Habsah, L.Y. Mooi,
S.M. Mohamed, J. Ethnopharmacol. 72 (2000) 395-402.
[8] Mustofa, E.N. Solikhah, S. Wahyuono, J. Trop. Public Health. 38 (2007) 609-615.
[9] R.S. Phillips, Clin. Microbial. Rev. 14 (2001) 155-171.
[10] P.G. Waterman, I. Muhammad, Phytochemistry. 24 (1985) 523-528.
[11] A.J. Marsaioli, A.F. Magalhaes, E.A. Rùveda, F. Reis, Phytochemistry. 19 (1980) 995-1002.
[12] M. Hamonniere, M. Leboeuf, A. Cavé, Phytochemistry. 16 (1977) 1029-1036.
[13] T. Murningsih, Subekti, K. Matsuura, H. Takahashi, M. Yamasaki, O. Yamamoto, Y. Maeda, K.
Katakura, M. Suzuki, S. Kobayashi, T. Chairul, J. Yoshihara, Vet. Med. Sci. 67 (2005) 829-831.