Synthesis and antimicrobial activity of some novel heterocycles containing thiazole, oxazole, thiazine, oxazine and triazole moiety

الموضوعات : Journal of the Iranian Chemical Research

Vijay V. Dabholkar ¹ (Organic Research Laboratory, Department of Chemistry, KC College, Churchgate, Mumbai, India)
Sunil R. Patil ² (Organic Research Laboratory, Department of Chemistry, KC College, Churchgate, Mumbai, India)
Rajesh V. Pandey ³ (Organic Research Laboratory, Department of Chemistry, KC College, Churchgate, Mumbai, India)

تاريخ الإرسال : 19 السبت , محرم, 1432 تاريخ التأكيد : 07 السبت , ربيع الثاني, 1432 تاريخ الإصدار : 15 الأحد , ربيع الثاني, 1432

الکلمات المفتاحية: Monobromoindandione, Thiocarbamide, Carbamide, 2-Aminothiophenol, 2-Aminophenol, triazole,

ملخص المقالة :

Indandione 1 was brominated to yield 2-bromoIndandione 2 which on further reacted with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol and triazoles to furnished 3-substituted aniline-2-thia-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 3, 3-substituted aniline-2-oxa-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 4, 2-Thia-5-aza-9-oxo-3,4-(3’-substituted) benzo-7,8-benzo-bicyclo [4.3.0]-1(6) nonene 5, 2-oxa-5-aza-9-oxo-(3, 4)-(7, 8)-dibenzo-bicyclo [4.3.0]-1(6) nonene 6, 3-substituted-(1,2,4) triazolo [4,5-b] [indeno (2,3-e)]-1,3,4-thiadiazine 7 respectively.

المصادر:

1] B. Kalluraya, B. Isloor, P.V. Frank, R.L. Jagadeesha, Indian J Heterocyclic Chem, 13 (2004) 245-247.
[2] J.V. Metzer, Comprehensive Heterocyclic Chemistry, edited by A. R. Katritzky, C.W. Rees, Pergamon Press, Oxford, 5 (1984) 328-331.
[3] J. Lambardino, E. Wiseman, C. Josephine, J. Med. Chem. 16 (1973) 493-495.
[4] M.E. Wolff, Burger’s Medicinal Chemistry, 116-122 (Wolff Vol. IV Part III), 889- 891.
[5] V.K. Pandey, S.K. Saxena, S.K. Bajpai, Indian J. Chem. 43B (2004) 1015-1017.
[6] A.K. Bhatt, H.G. Karadia, P.R. Shah, M.P. Parmar, H.D. Patel, Indian J. Heterocyclic Chem. 13 (2004) 281-283.
[7] K. Richardson, Current Med. Res. Opinion 12SI (1991) 60-62.
[8] R. Gupta, A.K. Gupta. S. Paul, Indian J. Chem. 37B (1998) 1211-1213.
[9] B.P. Sadhu, K. Gupta, Geobios 24 (1997) 181-184
[10] C.P. Joshua, J. Org. Chem. 28 (1963) 1293-1296.
[11] N. Rabjohn, Org. Synth. Coll. Vol IV, John Wiley, New York, 1963.
[12] R.Q. Brewster, F.B. Dains, J. Am. Chem. Soc. 58 (1936) 1364-1366.
[13] R.L. Mittal. S. Jain, J. Chem. Soc. (1969) 2148-2150.
[14] B.A. Arthington, C.J. Morrison, Microbiol. 38 (2000) 2254-2260.