واکسن های پیشتاز بین المللی و ایرانی علیه کرونا ویروس جدید: دسته بندی، ساختار شناسی، اثربخشی و عوارض
الموضوعات :سیده معصومه تقی زاده 1 , علیرضا ابراهیمی نژاد 2
1 - مرکز تحقیقات بیوتکنولوژی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
2 - مرکز تحقیقات بیوتکنولوژی، دانشگاه علوم پزشکی شیراز، شیراز، ایران
الکلمات المفتاحية: کووید-19, واکسن نوکلئیک اسید, واکسن ویروسی, واکسن حامل, واکسن پروتینی,
ملخص المقالة :
در پی انتشار جهانی کرونا ویروس جدید تلاش‌های گسترده بین المللی و ملی در جهت ساخت واکسن علیه این ویروس شکل گرفت. غول‌های دارویی از جمله شرکت‌های فایزر، جانسن بیوتک، آسترازنکا، سینوواک، مدرنا، بیونتک، بهارات، فینلای و گروه بیوتک ملی چین در کنار مراکز و موسسات تحقیقاتی بنام از جمله دانشگاه آکسفورد و مرکز تحقیقات گامالیا مثال‌هایی از شرکت‌ها و مراکزی است که توانستند در مسابقه ساخت و تولید واکسن کرونا موفق‌تر از دیگر رقبا عمل نمایند. در ایران نیز اقدام برای ساخت این واکسن به سرعت کلید خورد و شرکت‌ها و سازمان‌های ایرانی همچون شفا فارمد، ستاد اجرایی فرمان امام خمینی (ره)، وزارت دفاع، انیستیتو پاستور و موسسه تحقیقات واکسن و سرم سازی رازی خود را موظف به تلاش در این عرصه دانستند. در حال حاضر واکسن کرونای محصول این شرکت‌ها و موسسات یا مجوز مصرف دریافت نموده و یا در مراحل انتهایی مطالعات بالینی قرار دارند. مقالات مروری فراوانی در نقد و بررسی این واکسن‌ها در مجلات بین المللی به چاپ رسیده است اما اغلب این مقالات اشاره ای به تلاش‌های صورت گرفته در کشور ایران نداشته‌اند. لذا در مقاله پیش رو تلاش شده تا با بهره گیری از اطلاعات منتشره توسط سازمان بهداشت جهانی، مرکز کنترل بیماری‌های ایالات متحده، شرکت‌های دارویی، مراکز تحقیقاتی معتبر و سازمان‌های داخلی و خارجی به طبقه بندی، بررسی ساختار، اثربخشی و عوارض جانبی واکسن‌های کرونای پیشتاز بین المللی و ایرانی پرداخته شود
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