Review of measurement and analysis of biomarkers using inorganic complexes and metal-based nanomaterials
الموضوعات : Applied smart materials
1 - . Independent researcher
الکلمات المفتاحية: Biomarker, inorganic metal complexes, inorganic nanoparticles, imaging modalities, metal-based signal generation probes, nanotechnology,
ملخص المقالة :
Biomarkers are biochemical/physiological changes in body tissues or fluids that can be accurately and reproducibly measured. They can indicate the entire spectrum of the disease and potentially the choice of the type and dosage of drugs can increase the effectiveness and minimize effective therapeutic interventions. Therefore, the identification of biomarkers is of particular importance in the development of pharmaceuticals and moving towards personalized medicine. Nanotechnology as a new scientific field with novel combinations has taken the lead in the fields of medical diagnosis, imaging and therapeutic applications. Investigation of literatures determined that Signal generation probes based on inorganic complexes and metal-based nanomaterials can generally be one of the suitable candidates for diagnosis. Therefore, in this study, the importance of using inorganic chemistry and nanotechnology in the field of identifying biomarkers has been discussed. In the first part of the review, the main definitions in this field have been explained. Then, a set of biomarkers associated with a specific disease and number of methods for measuring biomarkers are described. In the next section, the use of inorganic metal complexes and nanoparticles in probes for sensing and imaging is discussed and finally, current challenges and future prospects are presented.
