مروری بر روش فتودینامیک تراپی با رویکرد حسگر های نوری مختلف
الموضوعات :پرنیا همتی 1 , سید مهدی طبایی 2 , مینا سادات نادری 3
1 - گروه زیست شناسی ، دانشکده علوم زیستی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران
2 - گروه پژوهشی لیزر پزشکی، مرکز تحقیقات لیزر در پزشــکی، پژوهشــکده یارا، سازمان جهاد دانشگاهی علوم پزشکی تهران،
3 - گروه بیوفیزیک، دانشکده علوم زیستی، دانشگاه آزاد اسلامی واحد تهران شمال، تهران، ایران
الکلمات المفتاحية: سرطان, پوست, فتودینایک تراپی, حسگر های نوری, لیزر کم توان,
ملخص المقالة :
فتودینامیک تراپی یک روش درمانی برای بیماری هایی مانند سرطان با حداقل تهاجم است. حساس کننده نور ، که به عنوان یک کاتالیزور در هنگام جذب نور عمل می کند، اکسیژن را به گونه های اکسیژن فعال سیتوتوکسیک تبدیل می کند که سلول های بدخیم را از طریق آپوپتوز ویا نکروز از بین می برد، عروق تومور را تخریب می کند و ایمنی را تحریک می کند. هدف از این مطالعه معرفی و بررسی عملکرد انواع حساسگر های نوری در درمان بیماری های مختلف از جمله بیماری های پوستی و سرطان پوست با روش فتودینامیک تراپی است . در این مطالعه ی مروری مقالات 10 سال اخیر در سایت هایgoogle scholar, PubMed, science direct, and Scopus, با عناوین حسگر های نوری ، فتودینامیک تراپی ، سرطان ، پوست و لیزر کم توان بررسی گردید. روش های درمانی مختلفی برای سرطان وجود دارد که روش درمانی فتودینامیکی یک روش درمانی امیدوار کننده برای انواع سرطان ها است . از مزایای این روش استفاده از تشعشعات غیر یونیزه کننده است که منجر به حداقل اسیب به DNA و بافت های اطراف می شود ، بنابراین این روش می تواند با توجه به بافت مورد نظر از حسگر های نوری مختلف با طول موج های نوری مختلف در بهبود روش های درمانی با مکانیسم منحصر به فرد خود اثر کمک کننده داشته باشد ..
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