Effect of Single Nucleotide Polymorphisms in IGF-1R Gene on Growth Rate Traits in Makooei Sheep
الموضوعات :
م. پسندیده
1
(Department of Genetics and Animal Breeding, Faculty of Animal and Aquatic Science, Sari Agricultural Science and Natural Resources University, Sari, Iran)
ق. رحیمی
2
(Department of Genetics and Animal Breeding, Faculty of Animal and Aquatic Science, Sari Agricultural Science and Natural Resources University, Sari, Iran)
و. همتی
3
(Department of Genetics and Animal Breeding, Faculty of Animal and Aquatic Science, Sari Agricultural Science and Natural Resources University, Sari, Iran)
الکلمات المفتاحية: Makooei sheep, PCR-SSCP, growth rate traits, <i>IGF-1R</i>,
ملخص المقالة :
Insulin-like growth factor 1 receptor (IGF-1R) is a main receptor of IGFs family which plays a critical role in the postnatal growth and skeletal growth in many species. However, there are few reports of IGF-1R gene structure and its effects on growth traits in sheep. The objectives of this study were detection of IGF-1R polymorphisms and assessment of their associations with growth traits in Iranian Makooei Sheep. Hence, 200 Makooei lambs were genotyped through polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP). The studied traits were birth weight (BW), weaning weight (WW), 6 months weight (6MW), average daily gains from birth to 3 months (ADG0-3), from 3 months to 6 months (ADG3-6), from birth to 6 months (ADG0-6) and corresponding Kleiber ratios (KR0-3, KR3-6, KR0-6).For this genetic position, three types of banding patterns (AA, AB and BB) were identified with the frequencies of 0.69, 0.16 and 0.15, respectively. In this study, IGF-1R genotypes indicated the significant associations with 6MW, ADG0-6, KR0-3 (P<0.05) and ADG0-3 (P<0.01). In all of the significant traits, The AAgenotype was linked to the highest values, while the BBgenotype was linked to the lowest values. The results of this study indicated that single nucleotide polymorphism (SNP) variation in IGF-1R gene can be used as a molecular marker for improving of growth traits in marker assisted selection programs in sheep.
Akis I., Oztabak K., Gonulalp I., Mengi A. and Un C. (2010). IGF-1 and IGF-1R gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds. Russian J. Genet. 46, 439-442.
Beavis W.D. (1998). QTL analyses: Power, precision, and accuracy. Pp. 145-162 in Molecular Dissection of Complex traits. A.H. Peterson, Ed. CRC Press, New York.
Byun S.O., Forrest R.H., Frampton C.M., Zhou H. and Hickford J.G.H. (2012). An association between lifespan and variation in insulin-like growth factor I receptor in sheep. J. Anim. Sci. 90, 2484-2487.
Byun S.O., Zhou H. and Hickford J.G.H. (2008). Polymorphism of the ovine insulin-like growth factor I receptor (IGFIR) gene. Mol. Cell. Probes. 22, 131-132.
Charge S.B.P. and Rudnicki M.A. (2004). Cellular and molecular regulation of muscle regeneration. Physiol. Rev. 84, 209-238.
Delafontaine P., Song Y.H. and Li Y. (2004). Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 24, 435-444.
El-Magd M., Abbas H., El-Kattawy A. and Mokhbatly A. (2013). Novel polymorphisms of the IGF1R gene and their association with average daily gain in Egyptian buffalo (Bubalus bubalis). Domest. Anim. Endocrinol. 45, 105-110.
Epaud R., Aubey F., Xu J., Chaker Z., Clemessy M., Dautin A.,Ahamed K., Bonora M., Hoyeau N., Fléjou J.F., Mailleux A., Clement A., Henrion-Caude A. and Holzenberger M. (2012). Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis. PLoS One. 7, e48071.
Falconer D.S. and Mackay T.F.C. (1996). Introduction to Quantitative Genetics. Longmans Green, Harlow, United Kingdom.
Froesch E.R., Schmid C.H.R., Schwander J.T. and Zapf J. (1985). Actions of insulin-like growth factors. Ann. Rev. Physiol. 47, 443-467.
Gholibeikifard A., Aminafshar M. and Hosseinpour Mashhadi M. (2013). Polymorphism of IGF-I and ADRB3 genes and their association with growth traits in the Iranian Baluchi sheep. J. Agric. Sci. Technol. 15, 1153-1162.
Hajihosseinlo A., Hashemi A., Razavi-Sheshdeh S. and Pirany N. (2013). Association of the polymorphism in the 5 flanking region of the ovine IGF-I gene with growth and development traits in Makui sheep of Iran. European J. Zool. Res. 2, 19-24.
Kleiber M. (1947). Body size and metabolic rate. Physiol. Rev. 27, 511-541.
Lei M., Peng X., Zhou M., Luo C., Nie Q. and Zhang X. (2008). Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits. BMC Genet. 9, 70.
Liang C., Yan P., Yao Y., Pei J., Guo X., Zeng Y., Bao P. and Chu M. (2010). A novel single nucleotide polymorphism (SNP) of the IGF1R gene and the association with growth traits in yak (brief report). Arch. Anim. Breed. 53, 626-628.
Meyer K. (2006). WOMBAT–A program for mixed model analyses by restricted maximum likelihood REML. J. Zhejiang Univ. Sci. B. 11, 815-21.
Miller S.A., Dykes D.D. and Polesky H.F. (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16(3), 1215-1225.
Moe H., Shimogiri T., Kamihiraguma W., Isobe H., Kawabe K., Okamoto S., Minvielle F. and Maeda Y. (2007). Analysis of polymorphisms in the insulin-like growth factor 1 receptor (IGF1R) gene from Japanese quail selected for body weight. Anim. Genet. 38, 659-661.
Mrode R.A. (2014). Linear Models for the Prediction of Animal Breeding Values. CABI, Wallingford, United Kingdom.
Negahdary M., Hajihosseinlo A. and Ajdary M. (2013). PCR-SSCP variation of IGF1 and PIT1 genes and their association with estimated breeding values of growth traits in Makooei Sheep. Genet. Res. Int. 2013, 1-6.
Nkrumah J.D., Sherman E.L., Li C., Marques E., H.C.J.D., Bartusiak R., Murdoch B., Wang Z., Basarab J.A. and Moore S.S. (2007). Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle. J. Anim. Sci. 85, 3170-3181.
O’Neill B.T., Lauritzen H.P.M.M., Hirshman M.F., Smyth G., Goodyear L.J. and Kahn C.R. (2015). Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis. Cell. Rep. 11, 1220-1235.
Pasandideh M., Rahimi-Mianji G. and Gholizadeh M. (2018). A genome scan for quantitative trait loci affecting average daily gain and Kleiber ratio in Baluchi Sheep. J. Genet. 97, 493-503.
Pasandideh M., Rahimi-Mianji G., Gholizadeh M. and Fontanesi L. (2017). Detection of genomic regions affecting reproductive traits in Baluchi sheep using high density markers. Anim. Prod. Res. 6, 29-41.
Pipalla D.L., Joshi C.G., Rank D.N., Brahmkshtri B.P. and Solanki J.V. (2004). PCR-SSCP typing of MHC in cattle and buffaloes. Indian J. Anim. Sci. 74, 637-639.
Proskura W.S. and Szewczuk M. (2014). The polymorphism in the IGF1R gene is associated with body weight and average daily weight gain in Pomeranian coarse wool ewes. Pakistan Vet. J. 34, 514-517.
Richardson A., Liu F., Adamo M.L., Van Remmen H. and Nelson J.F. (2004). The role of insulin and insulin-like growth factor-I in mammalian ageing. Best Pract. Res. Clin. Endocrinol. Metab. 18, 393-406.
Saadat-Noori M. and Siah-Mansoor S. (1992). Sheep Husbandary and Management. Ashrafi Publication, Tehran, Iran.
SAS Institute. (2002). SAS®/STAT Software, Release 9.1. SAS Institute, Inc., Cary, NC. USA.
Scholtz M.M. and Roux C.Z. (1988). The kleiber ratio (growth rate metabolic mass) as possible selection criteria in the selection of beef cattle. Pp. 220-225 in Proc. 7th World Congr. Sheep Beef Cattle Breed., Paris, France.
Singh P., Alex J.M. and Bast F. (2014). Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: Novel treatment strategies for cancer. Med. Oncol. 31, 1-14.
Su G., Christensen O.F., Ostersen T., Henryon M. and Lund M.S. (2012). Estimating additive and non-additive genetic variances and predicting genetic merits using genome-wide dense single nucleotide polymorphism markers. PLoS One. 7, e45293.
Tahmoorespur M., Valeh M., Nassiry M., Moussavi A. and Ansary M. (2009). Association of the polymorphism in the 5’flanking region of the ovine IGF-I gene with growth traits in the Baluchi sheep. S. Afr. J. Anim. Sci. 39, 97-101.
Trukhachev V., Skripkin V., Kvochko A., Kulichenko A., Kovalev D., Pisarenko S., Volynkina A., Selionova M., Aybazov M., Shumaenko S., Omarov A., Mamontova T., Yatsyk O. and Krivoruchko A. (2016). Polymorphisms of the IGF1 gene in Russian sheep breeds and their influence on some meat production parameters. Slovenian Vet. Res. 53, 77-83.
Wang W., Ouyang K., Su X., Xu M. and Shangguan X. (2006). Polymorphism of insulin-like growth factor 1 receptor gene in 12 pig breeds and its relationship with pig performance traits. Asian-Australasian. J. Anim. Sci. 19, 1541-1545.
Yeh F.C., Yang R. and Boyle T. (1999). Pop gene version 1.31, microsoft windows-based free ware for population genetic analysis. MS Thesis. University of Alberta, Edmonton, Canada.
