An Investigation on Population Structure and Inbreeding of Sangsari Sheep
الموضوعات :م. میرزایی ایلالی 1 , س. حسنی 2 , م. آهنی آذری 3 , ر. عبدالهپور 4 , س. نقویان 5
1 - Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran
2 - دانشگاه علوم کشاورزی و منابع طبیعی گرگان
3 - Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran
4 - Department of Animal Science, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Iran
5 - Department of Animal and Poultry Breeding and Genetics, Faculty of Animal Science, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran
الکلمات المفتاحية: genetic diversity, inbreeding, population structure, Sangsari sheep,
ملخص المقالة :
The aim of this study was to describe inbreeding and population structure in Sangsari sheep breeding station. For this reason, data from 7028 Sangsari sheep which were collected during 1987-2014 in Sangsari sheep breeding station located near to Damghan city, Semnan province were used. Lambs born during 2010-2014 were considered as reference population. The genetic structure analysis of the population was realized by the ENDOG (v.4.8) software. Mean inbreeding of total population and reference population was 0.28% and 0.70%, respectively. Average relatedness, realized effective population size based on individual increase in inbreeding, effective numbers of founders (fe),and founder genome equivalents (fg) were estimated 0.59%, 148.75, 140 and 49.97, respectively. Mean generation interval in present population was 4.24 years and average number of equivalent to discrete generations was estimated as 1.64. Average coancestry, effective number of ancestors (fa) and average equivalent complete generation were calculated 1.0005%, 76 and 3.02, respectively. Ratio of fe/fa which expresses the effect of population bottlenecks was 1.84. 50% of total genetic variation was explained by the 32 most influential ancestors. By monitoring parameters associated with genetic diversity and breeding management, the reduction of genetic diversity and probable harmful effects resulting from excessive increase of inbreeding can be prevented.
Analla M., Montilla J.M. and Serradilla J.M. (1998). Analyses of lamb weight and ewe litter size in various lines of Spanish Merino sheep. Small Rumin. Res. 29, 255-259.
Ballou J.D. and Lacy R.C. (1995). Identifying genetically important individuals for management of genetic diversity in pedigreed populations. Pp.76-111 in Population Management for Survival and Recovery. Analytical Methods and Strategies in Small Population Conservation. J.D. Ballou, M. Gilpin and T.J. Foose, Eds. Columbia University Press, New York.
Bink M.C.A.M., Anderson A.D., Van De Weg W.E. and Thompson E.A. (2008). Comparison of marker-based pairwise relatedness estimators on a pedigreed plant population. Theor. Appl. Genet. 117, 843-855.
Boichard D., Maignel L. and Verrier E. (1997). The value of using probabilities of gene origin to measure genetic variability in a population. Genet. Sel. Evol. 29, 5-23.
Caballero A. and Toro M.A. (2000). Interrelations between effective population size and other pedigree tools for the management of conserved populations. Genet. Res. (Cambridge). 75, 331-343.
Caballero A. and Toro M.A. (2002). Analysis of genetic diversity for the management of conserved subdivided populations. Conserv. Genet. 3, 289-292.
Cervantes I., Goyache F., Molina A., Valera M. and Gutiérrez J.P. (2008). Application of individual increase in inbreeding to estimate effective sizes from real pedigrees. J. Anim. Breed. Genet. 125, 301-310.
Ceyhan A., Kaygisiz A. and Sezenler T. (2011). Effect of inbreeding on preweaning growth traits and survival rate in Sakiz sheep. J. Anim. Plant Sci. 21(1), 1-4.
Cole J.B., Franke D.E. and Leighton E.A. (2004). Population structure of a colony of dog guides. J. Anim. Sci. 82(10), 2906-2912.
Dario C. and Bufano G. (2003). Efecto de la endogamia sobre la producción láctea en la raza ovina Altamurana (effect of inbreeding on milk production in Altamurana sheep breed). Arch. De Zootec. 52, 401-404.
Ercanbrack S.K. and Knight A.D. (1991). Effects of inbreeding on reproduction and wool production of Rambouillet, Targhee, and Columbia ewes. J. Anim. Sci. 69, 4734-4744.
Eteqadi B., Ghavi Hossein-Zadeh N. and Shadparvar A.A. (2014). Population structure and inbreeding effects on body weight traits of Guilan sheep in Iran. Small Rumin. Res. 119, 45-51.
Falconer D.S. and Mackay T.F.C. (1996). Introduction to Quantitative Genetics. Longman Group Ltd., England, United Kingdom.
FAO. (1998). Management of Small Populations at Risk. Food and Agriculture Organization of the United Nations (FAO), Rome, Italy Food Agric. Org. United Nations, Rome, Italy.
Fernandez J., Villanueva B., Pong-Wong R. and Toro M.A. (2005). Efficiency of the use of pedigree and molecular marker information in conservation programs. Genet. Sel. Evol. 170, 1313-1321.
Frankham R., Ballou J.D. and Briscoe D.A. (2003). Introduction to Conservation Genetics. Cambridge University Press, Cambridge, United Kingdom.
Ghafouri-Kesbi F. (2010). Analysis of genetic diversity in a close population of Zandi sheep using genealogical information. J. Genet. 89, 479-483.
Gowane G.R., Chopra A., Misra S.S. and Prince L.L.L. (2014). Genetic diversity of a nucleus flock of Malpura sheep through pedigree analyses. Small Rumin. Res. 120, 35-41.
Gowane G.R., Prakash V., Chopra A. and Prince L.L.L. (2013). Population structure and effect of inbreeding on lamb growth in Bharat Merino sheep. Small Rumin. Res. 114, 72-79.
Goyache F., Gutierrez J.P., Fernandez I., Gomes E., Alvarez I., Díez J. and Roy L.J. (2003). Using pedigree information to monitor genetic variability of endangered population: the Xalda sheep breed of Asturias as an example. J. Anim. Breed. Genet. 120, 95-105.
Gutiérrez J.P., Altarriba J., Díaz C., Quintanilla R., Can͂ón J. and Piedrafita J. (2003). Pedigree analysis of eight Spanish beef cattle breeds. Genet. Sel. Evol. 35, 43-63.
Gutiérrez J.P., Cervantes I. and Goyache F. (2009). Improving the estimation of realized effective population sizes in farm animals. J. Anim. Breed. Genet. 126, 327-332.
Gutiérrez J.P., Cervantes I., Molina A., Valera M. and Goyache F. (2008). Individual increase in inbreeding allows estimating effective sizes from pedigrees. Genet. Sel. Evol. 40, 359-378.
Gutiérrez J.P. and Goyache F. (2005). A note on ENDOG: A computer program for analyzing pedigree information. J. Anim. Breed. Genet. 122, 172-176.
Hammami H., Croquet C., Stoll J., Rekik B. and Gengler N. (2007). Genetic diversity and joint pedigree analysis of two importing Holstein populations. J. Dairy. Sci. 90, 3530-3541.
Hinrichs D. and Thaller G. (2011). Pedigree analysis and inbreeding effects on calving traits in large dairy herds in Germany. J. Dairy Sci. 94, 4726-4733.
James J.W. (1977). A note on selection differentials and generation length when generations overlap. Anim. Prod. 24, 109-112.
James J.W. (1972). Computation of genetic contributions from pedigrees. Theor. Appl. Genet. 42, 272-273.
Karhunen M. and Ovaskainen O. (2012). Estimating population-level coancestry coefficients by an admixture F-model. Genetics. 192, 609-617.
Kasiriyan M.M., Hafezian S.H. and Hassani N. (2011). Genetic polymorphism BMP15 and GDF9 genes in Sangsari sheep of Iran. Int. J. Genet. Mol. Biol. 3(1), 31-34.
Khan M.S., Ali A., Hyder A.U. and Chatta A.I. (2007). Effect of inbreeding on growth and reproduction traits of Beetal goats. Arch. Tierz. 50, 197-203.
Kristensen T.N. and Sørensen A.C. (2005). Inbreeding– lessons from animal breeding, evolutionary biology and conservation genetics. Anim. Sci. 50, 121-133.
Lacy R.C. (1989). Analysis of founder representation in pedigrees: founder equivalents and founder genome equivalents. Zoo Biol. 8, 111-123.
Lamberson W.R. and Thomas D.L. (1984). Effects of inbreeding in sheep: A review. Anim. Breed. Abstr. 52, 287-297.
Leroy G., Mary-Huard T., Verrier E., Danvy S., Charvolin E. and Danchin-Burge C. (2013). Methods to estimate effective population size using pedigree data: Examples in dog, sheep, cattle and horse. Genet. Sel. Evol. 45, 1-10.
Lukas F.K. and Donald M.W. (2002). Inbreeding effects in wild populations. Ecol. Evol. 17(5), 230-241.
Lush J.L. (1945). Animal Breeding Plans. Iowa State College Press, Ames, Iowa, USA.
MacCluer J.W., Boyce A.J., Dyke B., Weitkamp L.R., Pfenning D.W. and Parsons C.J. (1983). Inbreeding and pedigree structure in Standard bred horses. J. Hered. 74, 394-399.
Maignel L., Boichard D. and Verrier E. (1996). Genetic variability of French dairy breeds estimated from pedigree information. Interbull Bull. 14, 49-54.
Malécot G. (1948). Les Mathématiques de lHérédité. Massonet Cie, Paris, France.
Martínez R.A., García D., Gallego J.L., Onofre G., Pérez J. and Ca˜nón J. (2008). Genetic variability in Colombian Creole cattle populations estimated by pedigree information. J. Anim. Sci. 86, 545-552.
Melka M.G. and Schenkel F. (2010). Analysis of genetic diversity in four Canadian swine breeds using pedigree data. Canadian J. Anim. Sci. 90(3), 331-340.
Meuwissen T.I. and Luo Z. (1992). Computing inbreeding coefficients in large populations. Genet. Sel. Evol. 24, 305-313.
Mokhtari M.S., Moradi Shahrbabak M., Esmailizadeh A.K., Abdollahi-Arpanahi R. and Gutierrez J.P. (2013). Genetic diversity in Kermani sheep assessed from pedigree analysis. Small Rumin. Res. 114, 202-205.
Mokhtari M.S., Moradi Shahrbabak M., Esmailizadeh A.K., Abdollahi-Arpanahi R. and Gutierrez J.P. (2014). Pedigree analysis of Iran-Black sheep and inbreeding effects on growth and reproduction traits. Small Rumin. Res. 116, 14-20.
Nei M. and Chesser R.K. (1983). Estimation of fixation indices and gene diversities. Ann. Hum. Genet. 47, 253-259.
Pedrosa V.B., Santana Jr. M.L., Oliveira P.S., Eler J.P. and Ferraz, J.B.S. (2010). Population structure and inbreeding effects on growth traits of SantaInês sheep in Brazil. Small Rumin. Res. 93, 135-139.
Rzewuska K., Klewiec J. and Martyniuk E. (2005). Effect of inbred on reproduction and body weight of sheep in a closed Booroola flock. Anim. Sci. Pap. Rep. 4, 237-247.
Selvaggia M., Darioa C., Peretti V., Ciotolac F., Carnicellaa D. and Darioa M. (2010). Inbreeding depression in Leccese sheep. Small Rumin. Res. 89, 42-46.
Sørensen A.C., Sørensen M.K. and Berg P. (2005). Inbreeding in Danish dairy cattle breeds. J. Dairy Sci. 88, 1865-1872.
Sørensen A.C., Sørensen M.K. and Berg P. (2004). Inbreeding in Danish dairy cattle breeds. Pp. 5-8 in Proc. 55th Ann. Meet. European Assoc. Anim. Prod. Bled., Slovenia, Balkans.
Tahmoorespour M. and Sheikhloo M. (2011). Pedigree analysis of the closed nucleus of Iranian Baluchi sheep. Small Rumin. Res. 99, 1-6.
Teegen R., Edel C. and Thaller G. (2009). Population structure of the Trakehner Horse breed. Animal. 3, 6-15.
Valera M., Molina A., Gutierréz J.P., Gómez J. and Goyache F. (2005). Pedigree analysis in the Andalusian horse: Population structure, genetic variability and influence of the Carthusian strain. Livest. Prod. Sci. 95, 57-66.
Van Wyk J.B., Fair M.D. and Cloete S.W.P. (2009). Case study: The effect of inbreeding on the production and reproduction traits in the Elsenburg Dormer sheep stud. Livest. Sci. 120, 218-224.
Vozzi P.A., Marcondes C.R., Bezerra L.A.F. and Lobo R.B. (2007). Pedigree analyses in the breeding program for Nellore cattle. Genet. Mol. Res. 29, 482-485.
Woolliams J.A. and Mantysaari E.A. (1995). Genetic contributions of Finnish Ayshire bulls over four generations. Anim. Sci. 61, 177-187.
Wright S. (1978). Evolution and the Genetics of Populations. University of Chicago Press, Chicago, Illinois.
Wright S. (1965). The interpretation of population structure by F-statistics with special regard to systems of mating. Evolution. 19, 395-420.
