Estrogens Receptors-New Players in Spermatogenesis
الموضوعات :
1 - Department of Physiology Reproduction and Shelter Management, Central Institute for Research on Goats, Mathura, India
الکلمات المفتاحية: estrogen, Testis, aromatase, estrogen receptors,
ملخص المقالة :
The mammalian testis is a complex organ that serves two important functions, synthesis of steroids, with significant amount of estrogenic hormones produced and production of spermatozoa. Estrogen receptors (ERs) are expressed in cells of the testis as well as the epididymal epithelium. We have demonstrated that estrogen receptor expression is higher in reproductive tissues as compared to non-reproductive tissues. In addition to this, western blot analysis showed a signal for estrogen receptor.
Carreau S. and Hess R.A. (2010). Oestrogens and spermatogenesis. Phil. Trans. R. Soc. B. 365, 1517-1535.
Carreau S., Bouraima-Lelong H. and Delalande C. (2011). Estrogens: new players in spermatogenesis. Reprod. Biol. 11(3), 174–193.
Filardo E., Quinn J., Pang Y., Graeber C., Shaw S., Dong J. and Thomas P. (2007). Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology. 148, 3236-3245.
Hall J.M., Couse J.F. and Korach K.S. (2001). The multifaceted mechanisms of estradiol and estrogen receptor signaling. J. Biol. Chem. 276, 36869-36872.
Hess R.A., Zhou Q. and Nie R. (2002). The role of estrogens in the endocrine and paracrine regulation of the efferent ductules, epididymis and vas deferens. Pp. 317-338 in The Epididymis: From Molecules to Clinical Practice. B. Robaire and B.T. Hinton, Eds. Kluwer Academic/Plenum Press, New York.
Lucas T.F., Siu E.R., Esteves C.A., Monteiro H.P., Oliveira C.A., Porto C.S. and Lazari M.F. (2008). 17-beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat sertoli cells. Biol. Reprod. 78, 101-114.
O'Donnell L., Robertson K.M., Jones M.E. and Simpson E.R. (2001). Estrogen and spermatogenesis. Endocrinol. Rev. 22, 289-318.
Oliveira R.L., Nogueira J.C., Mahecha G.A.B. and Oliveira C.A. (2012). Seasonal variation in estrogen receptor ERα, but not ERβ, androgen receptor and aromatase, in the efferent ductules and epididymis of the big fruit-eating bat Artibeus lituratus. Gen. Comp. Endocrinol. 179, 1-13.
Saraswat S., Rout P.K., Kharche S.D., Goel A.K., Jinda S.K. and Kumar S. (2015). Estrogen receptor gene 1 expression in male goat. Iranian J. Vet. Res. 17, 56-58.
Solakidi S., Psarra A.M., Nikolaropoulos S. and Sekeris C.E. (2005). Estrogen receptors alpha and beta (ERalpha and ERbeta) and androgen receptor (AR) in human sperm: localization of ER beta and AR in mitochondria of the midpiece. Hum. Reprod. 20, 3481-3487.