Parathyroid Hormone-Related Peptide and Vitamin D in Phosphocalcic Metabolism for Dromedary Camel
الموضوعات :
1 - Department of Biology, Faculty of Science Ben M'sik, PB 7955,CasablancaUniversity, Laboratory ofPhysiopathology and Biomolecular Genetics, Sidi Othmane, Casablanca, Morocco
2 - International Centerfor Agronomic Research for Development-EnvironmentsandSocieties(CIRAD-ES), International Campus of Baillarguet, 34398 Montpellier, Cedex 5, France
الکلمات المفتاحية: Calcium, dromedary camel, PTHrP, vitamin D,
ملخص المقالة :
In mammals, phosphocalcic and bone metabolisms are mainly regulated by parathyroid hormone, parathyroid hormone-related peptide (PTHrP) and 1α,25-dihydroxyvitamin D or calcitriol. In camels, circulating levels of calcitriol are 10 times higher than those determined in other ruminants and further increase during early lactation. Calcitriol and parathyroid-related peptide stimulate intestinal absorption of calcium and phosphorus, and phosphocalcic excretion by the mammary glands to maintain breast milk production in the same species. These endocrinian features allow, on one hand to improve the uptake of calcium and phosphorus in the adult, and on the other, to meet the phosphocalcic needs during growth and development of the young calf, in a precarious medium. In camels, the status of vitamin D varies with the season and the postpartum stage. Hypocalcemia and hypophosphatemia due to a deficiency of vitamin D are responsible for many bone disorders which could be corrected by a diet rich in calcium, phosphorus and vitamin D.
Abbas S.K., Pickard D.W., Illingworth D., Storer J., Purdie D.W., Moniz C., Dixit M., Caple I.W., Ebeling P.R., Rodda C.P., Martin T.J. and Care A.D. (1990). Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes. J. Endocrinol.124, 319-325.
Allen W.M. and Samson B.F. (1985). Milk fever and calcium metabolism. J. Vet. Pharmacol. Ther. 8, 19-29.
Ardawi M.S. , Nasrat H.A. and BA'Aqueel H.S. (1997). Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study. Eur. J. Endocrinol.137, 402-409.
Barlet J.P. (1975). Influence de la 1α-hydroxycholécalciférol sur la calcémie et la phosphatémie des Bovins. CR Acad. Sci. (Paris) D 281, 1497-1500.
Barlet J.P., Champredon C., Coxam V., Davicco M.J. and Tressol J.C. (1992). Parathyroid hormone-related peptide might stimulate calcium secretion into the milk goats. J. Endocrinol. 132, 353-359.
Barlet J.P., Davicco M.J. and Coxam V. (1995). Croissance osseuse au cours des périodes fœtale et néonatale: rôle du peptide apparenté à l’hormone parathyroïdienne. INRA Production Animale. 8, 177-187.
Barlet J.P., Nguyen T.M., Davicco M.J., Dardillat C., Lefaivre J. and Garabedian M. (1981). Plasma concentrations of vitamin D metabolites in the bovine species during the perinatal period. Reprod. Nutr. Dev. 21, 127-134.
Barling P.M., Liu H., Matich J., Mount J., Ka Wai Lai A., Ma L. and Basford Nicholson L.F. (2004). Expression of PTHrP and the PTH/PTHrP receptor in growing red deer antler. Cell. Biol. Int. 28, 661-673.
BengoumiM., Davicco M.J., Coxam V., De Lafarge F. and Barlet J.P. (1996). Effect of 1 alpha-hydroxycholecalciferol on calcium and phosphorus concentration in goat milk. Small Rumin. Res. 21, 45-49.
BonniwellM.A., Smith B.S., Spence J.A., Wright H. and Ferguson D.A. (1988). Rickets associated with vitamin D deficiency in young sheep. Vet. Rec.122, 386-388.
Braithwaite G.D. (1978). The effect of 1-α-hydroxycholecalciferol on calcium and phosphorus metabolism in the lactating ewe. Br. J. Nutr. 40, 387-392.
Broadus A.E., Mangin M., Ikeda K., Insogna K.L., Weir E.C., Burtis W.J. and Stewart A.F. (1988). Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N. Engl. J. Med.319, 556-563.
Budayr A.A., Halloran B.P., King J.C., Diep D., Nissenson R.A. and Strewler G.J. (1989). High levels of a parathyroid hormone-like protein in milk. Proc. Natl. Acad. Sci. USA86, 7183-7185.
Colston K.W., Berger U., Wilson P., Hadcocks L., Naeem I., Earl H.M. and Coombes R.C. (1988). Mammary gland 1,25-dihydroxy vitamin D3 receptor content during pregnancy and lactation. Mol. Cel. Endocrinol. 60, 15-22.
DeLuca H.F. (2004). Overview of general physiologic features and functions of vitamin D. Am. J. Clin. Nutr.80, 1689S-1696S.
Eidgenössische Forschungsanstalt für Nutztiere-RAP. (1999). Fütterungsempfehlungen und Nährwerttabellen für Wiederkäuer. LBL. Pages 174-208.
El Khasmi M., Riad F., Safwate A., Bengoumi M., Hidane K., Davicco M.J., Coxam V., Faye B. and Barlet J.P. (2000a). Effet du peptide apparenté à l’hormone parathyroïdienne sur l’absorption intestinale du xylose chez le chamelon nouveau-né du Sud marocain. Rev. Elev. Med. Vet. Pays Trop. 53, 120-121.
El Khasmi M., Riad F., Safwate A., Bengoumi M., Hidane K., Davicco M.J., Coxam V., Faye B. and Barlet J.P. (2000b). Evolution comparée de quelques paramètres minéraux, de l'ostéocalcine, du 25(OH)D et du 1,25(OH)2D chez la chamelle du sud marocain et son chamelon nouveau-né. Rev. Elev. Med. Vet. Pays Trop. 53, 115-119.
El Khasmi M., Riad F., Safwate A., Farh M., Belhouari A., Hidane K., El Abbadi N., Faye B. and Coxam V. (2003a). Exploration of intestinal absorption and renal excretion of calcium by stable strontium test in camels (Camelus dromedarius). J. Camel Practice Res. 10, 131-134.
El Khasmi M., Riad F., Safwate A., Farh M., El Abbadi N., Davicco M.J., Coxam V. and Faye B. (2008). Parathyroid hormone-related peptide stimulates intestinal strontium absorption in Camels (Camelus dromedarius). J. Camelid Sci. 1, 18-23.
El Khasmi M., Riad F., Safwate A., Farh M., Faye B., El Abbadi N., Lalaoui Kh., Coxam V., Davicco M.J. and Barlet J.P. (2001a). Influence de la 1,25-dihydroxyvitamine D3 sur l'excrétion mammaire du calcium et du phosphore chez la chamelle allaitante. Revue Elev. Méd. Vét. Pays Trop. 54, 277-280.
El Khasmi M., Riad F., Safwate A., Farh M., Hidane K., El Abbadi N., Coxam V. and Faye B. (2003b). Régulation de l’absorption intestinale du calcium chez le chamelon nouveau-né (Camelus dromedarius). Revue Elev. Méd. Vét. Pays Trop. 56, 89-94.
El Khasmi M., Riad F., Safwate A., Hidane K., Faye B., Davicco M.J., Coxam V. and Barlet J.P. (2001b). Postpartum evolution of mammary secretion of minerals and 25-hydroxyvitamin D in lactating camels (Camelus dromedarius). J. Camel Practice Res.8, 131-135.
FayeB. and Bengoumi M. (2000). Le dromadaire face à la sous-nutrition minérale: un aspect méconnu de son adaptabilité aux conditions désertiques. Sécheresse. 11, 155-161.
Filipović N., Stojević Z., Zdelar-Tuk M. and Kusec, V. (2008). Plasma parathyroid hormone-related peptide and bone metabo lism in periparturient dairy cows. Acta Vet. Hung.56, 235-244.
FitzpatrickL.A., Coleman D.T. and Bilezikian J.P. (1992). Disorders of Bone and Mineral Metabolism. Raven Press, New York. Pages 123-148.
Gao Y. and Raj J.U. (2005). Parathyroid hormone-related protein-mediated responses in pulmonary arteries and veins of newborn lambs. American J. Physiol. Lung Cell. Mol. Physiol.289, L60-L66.
GayC.C. and Besser T.E. (1991). Colostrum and feeding management of the dairy calf during the first two days of life. Large Animal Clinical Nutrition (Naylor JM, Ralston SL, eds), Mosby Year Book, St. Louis. Pages 242-247.
GoffJ.P. (2000). Pathophysiology of calcium and phosphorus disorders. Metabolic disorders of ruminants. Vet. Clin. North American. Food Anim. Pract. 16, 319-337.
HidiroglouM. and Proulx J.G. (1982). Factors affecting the calcium, magnesium and phosphorus content of beef cow milk. Can.J. Comp. Med.46, 212-214.
HolickM.F. (2007). Vitamin D deficiency. N. Engl. J. Med. 357, 266-281.
Horst R.L., Goff J.P. and Reinhardt T.A. (1994). Calcium and vitamin metabolism in the dairy cows. J. Dairy Sci. 77, 1936-1951.
Horst R.L., Goff J.P., Reinhardt T.A. (2005). Adapting to the transition between gestation and lactation: differences between rat, human and dairy cow. J. Mammary Gland Biol. Neoplasia. 10, 141-156.
Horst R.L., Hove K., Littledike E.T., Reinhardt T.A., Uskokovic M.R. and Partridge J.J. (1983). Plasma concentrations of 1,25-dihydroxyvitamin D, 1,24R,25-trihydroxyvitamin D3, and 2,25,26-trihydroxyvitamin D3 after their administration to dairy cows.J. Dairy Sci.66, 1455-1460.
Karmali R., Schiffmann S.N., Vanderwinden J.M., Hendy G.N., Nys-DeWolf N., Corvilain J., Bergmann P. and Vanderhaeghen J.J. (1992). Expression of mRNA of parathyroid hormone-related peptide in fetal bones of the rat. Cell. Tissue Res.270, 597-600.
KatariaN. and Kataria A.K. (2006). Serum C-terminal parathyroid hormone levels in dromedaries. J. Camel Pract. Res.13, 37-39.
KchoukM. and Durand M. (1958). Quelques dosages chimiques dans le sang des dromadaires de Tunisie. Archives de l’Institut Pasteur de Tunis. 35, 3-4.
Kistral-Boneh E., Froom P. and Harari G. (1999). Fibrous osteodystrophy in dromedary camels (Camelus dromedarius). J. Zool. Wildlife Med. 30, 577-583.
KocabagliN., Riond J.L., Küng K. and Wanner M. (1995). Parathyroid hormone-related protein and calcium concentrations in milk and blood of ewes. Dom. Anim. Endocrin. 12, 215-218.
Kurmann A. and Indyk H. (1994). The endogenous vitamin D content of bovine milk: Influence of season. Food Chem. 50, 75-81.
Law F.M., Moate P.J., Leaver D.D., Diefenbach-Jagger H., Grill V., Ho P.W. and Martin T.J. (1991). Parathyroid hormone related protein in milk and its correlation with bovine milk calcium. J. Endocrinol. 128,21-26.
LiesegangA., Risteli J. and Wanner M. (2006). The effects of first gestation and lactation on bone metabolism in dairy goats and milk sheep. Bone.38, 794-802.
Mäenpää P.H., Koskinen T. and Koskinen E. (1988). Serum profiles of vitamins A, E and D in mares and foals during different seasons. J. Anim. Sci.66, 1418-1423.
ManenD., Palmer G., Bonjour J.P. and Rizzoli R. (2000). Positive and negative control of the expression of parathyroid hormone (PTH)/PTH-related protein receptor via proximal promoter P3 in human osteoblast-like cells. J. Clin. Endocrinol. Metab. 85, 3376-3382.
Mc Cuaig K.A., Clarke J.C. and White J.H. (1994). Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor. Proc. Natl. Acad. Sci. 91, 5051-5055.
Mc Dowell L.R. (1989). Vitamins in Animal Nutrition: Comparative Aspects to Human Nutrition. Academic Pr San Diego. Pages 55-92.
MohamedS.E. (2008). Statut en vitamine D chez les dromadaires (Camelus dromedarius). Res. J. Biol. Sci. 3, 446-447.
MokL.L., Ajiwe E., Martin T.J., Thompson J.C. and Cooper C.W. (1989). Parathyroid hormone-related protein relaxes rat gastric smooth muscle and shows cross-desensitization with parathyroid hormone. J. Bone Miner. Res. 4, 433-439.
Naito Y., Goff J.P., Horst R.L. and Reinhardt T.A. (1989). Effects of continuous administration of 1,25-dihydroxyvitamin D3 on plasma minerals and unoccupied mucosal 1,25-dihydroxyvitamin D3 receptor concentrations. J. Dairy Sci. 72, 2936-2941.
Naito Y., Watanabe E., Oshibe A., Sato R. and Murakami D. (1983). Plasma level of 1,25-dihydroxyvitamin D in neonatal calves. NipponJuigaku Zasshi.45, 533-535.
NamiokaT., Yamagishi N., Okura N., Akasaka S., Abe T., Chida H., Sat S. and Naito Y. (2008). Transdermal absorption of 1,25-dihydroxyvitamin D3 in cattle. Jpn. J. Vet. Clinics. 31, 1-5.
NationalResearch Council. (1985). Nutrient Requirements of Sheep. 6th ed. DC: National Acad Pr, Washington. Pages 23-24.
Nonnecke B.J., Reinhardt T.A. and Waters W.R. (2009). Short communication: The preruminant calf as a model for characterizing the effects of vitamin D status in the neonate . J. Dairy Sci.92, 5692-5696.
OkuraN., Yamagishi M., Naito Y., Kanno K. and Koiwa M. (2004). Technical Note: Vaginal absorption of 1,25(OH)2D3 in cattle. J. Dairy Sci. 87, 2416-2419.
Onda K., Sato A., Yamaguchi M., Matsuki N., Ono K. and Wada Y. (2006). Parathyroid hormone-related protein (PTHrP) and Ca levels in the milk of lactating cows. J. Vet. Med. Sci. 68, 709-713.
Parker J.E., Timm K.I., Smith B.B., Van Saun R.J., Winters K.M., Sukon P. and Snow C.M. (2002). Seasonal interaction of serum vitamin D concentration and bone density in alpacas. American. J. Vet. Res.63, 948-953.
Philbrick W.M., Wysolmerski J.J., Galbraith S., Holt E., Orloff J.J., Yang K.H., Vasavada R.C., Weir E.C., Broadus A.E. and
Stewart A.F. (1996). Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol. Rev. 76, 127-173.
RajaramanV., Nonnecke B.J. and Horst R.L. (1997). Effects of oil on fat-soluble vitamins in serum and immune function in calves. J. Dairy Sci.80, 2380-2390.
RatcliffeW.A., Thompson G.E., Care A.D. and Peaker M. (1992). Production of parathyroid hormone-related protein by the mammary gland of the goat. J. Endocrinol.133, 87-93.
Riad F. (1995). Régulation endocrinienne du métabolisme hydro-électrolytique et phosphocalcique chez le dromadaire. Thesis, HassanII-Mohammedia University, faculty of sciences II, Ben M’sik, Casablanca, Marocco.
Riad F., Bengoumi M., Davicco M.J., Safwate A. and Barlet J.P. (1994). Influence of 1-alfa hydroxycholecalciferol on calcium and phosphorus concentration in camel milk. J. Dairy Res. 61, 567-571.
Riad F., Lefaivre J. and Barlet J.P. (1987). 1,25-dihydroxycholecal- ciferol regulates salivary phosphate secretion in cattle. J. Endocrinol. 112, 427-430.
Rodan S.B., Wesolowski G., Ianacone J., Thiede M.A. and Rodan G.A. (1989). Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. J. Endocrinol.122, 219-227.
Rong H., Hydbring E., Olsson K., Burtis W.J., Rankin W., Grill V. and Bucht E. (1997). Parathyroid hormone-related protein in neonatal and reproductive goats determined by a sensitive time-resolved immunofluorometric assay. Eur. J. Endocrinol. 136, 546-551.
RosolT.J. and Capen C.C. (1997). Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorus, magnesium) metabolism. Pages 619-702. Clinical Biochemistry of Domestic Animals. Kaneko, (Harvey, J. J. W. and Bruss, M. L. eds) 5th edition, Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto.
RossR., Halbert K. and Tsang R.C. (1989). Determination of the production and metabolic clearance rates of 1,25-dihydroxyvitamin D3 in the pregnant sheep and its chronically catheterized fetus by primed infusion technique. Pediatr. Res.26, 633-638.
Shany S., Yagil R. and Berlyne G.M. (1978). 25-hydroxy-cholecalciferol levels in camel, sheep and goat. Comp. Biochem. Physiol. 59, 139-140.
Smith B.B. and Van Saun R.J. (2001). Seasonal changes in serum calcium, phosphorus, and vitamin D concentrations in llamas and alpacas. American J. Vet. Res.62, 1187-1193.
Smith B.S., Wright H. and Brown K.G. (1987). Effect of vitamin D supplementation during pregnancy on the vitamin D status of ewes and their lambs. Vet. Rec.28, 199-201.
SteichenJ.J., Tsang R.C., Gratton T.L., Hamstra A. and DeLuca H.F. (1980). Vitamin D homeostasis in the perinatal period: 1,25-dihydroxyvitamin D in maternal, cord, and neonatal blood. N. Engl. J. Med. 302, 315-319.
Stelwagen K. and Callaghan M.R. (2003). Regulation of mammary tight junctions through parathyroid hormone-related peptide-induced activation of apical calcium channels. J. Endocrinol.178, 257-264.
Taylor M.S., Knowlton K.F., Mc Gilliard M., Seymour W.M. and Herbein J.H. (2008). Blood mineral, hormone, and osteocalcin responses of multiparous jersey cows to an oral dose of 25-Hydroxyvitamin D3 or vitamin D3 before parturition. J. Dairy Sci.91, 2408-2416.
Thiede M.A. (1989). The mRNA encoding a parathyroid hormone-like peptide is produced in mammary tissue in response to elevations in serum prolactin. Mol. Endocrinol.3, 1443-1447.
Thompson G.E., Ratcliffe W.A., Hughes S., Abbas S.K. and Care A.D. (1994). Local control of parathyroid hormone-related protein secretion by the mammary gland of the goat. Comp. Biochem. Physiol. Comp. Physiol.108, 485-490.
Thurston A.W., Cole J.A., Hillman L.S., Im H., Thorne K, Krause W.J., Jones J.R., Eber S.L. and Forte L.R. (1990). Purification and properties of parathyroid hormone-related peptide isolated from milk. Endocrinology.126, 1183-1190.
Van Cromphaut S.J., Dewerchin M., Hoenderop J.G., Stockmans I., Van Herck E., Kato S., Bindels R.J., Collen D., Carmeliet P., Bouillon R. and Carmeliet G. (2001). Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc. Natl. Acad. Sci. 98, 13324-13329.
Van SaunR.J. (2004). Vitamin D-responsive rickets in neonatal lambs. Can.Vet. J.45, 841-844.
Van Saun R.J., Smith B.B. and Watrous B.J. (1996). Evaluation of vitamin D status of llamas and alpacas with hypophosphatemic rickets. J. American Vet. Med. Assoc.209, 1128-1133.
VanHouten J.N., Dann P., Stewart A.F., Watson C.J., Pollak M., Karaplis A.C. and Wysolmerski J.J. (2003). Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J. Clin. Invest.112, 1429-1436.
Verstuyf A., Carmeliet G., Bouillon R. and Mathieu C. (2010). Vitamin D: a pleiotropic hormone.Kidney Int.78, 140-145.
Watson P.H., Westhusin M.E. and Watson A.J. (2001). Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation. Anat. Embryol. 203,175-184.
Webb A.R., Kline L. and Holick M.F. (1988). Influence of season and altitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J. Clin. Endocrinol. Metab.67,373-378.
Yamagishi N., Ayukawa Y., Lee I., Oboshi K. and Naito Y. (2005). Calcium metabolism in cows receiving an intramuscular injection of 1,25-dihydroxyvitamin D3 combined with prostaglandin F(2alpha) closely before parturition. J. Vet. Sci.6,165-167.
Zhang Y.Y., Liu P.Y., Lu Y., Xiao Liu Y.J., Long J.R., Shen H., Zhao L., Elze L.J.R.R. and Deng H.W. (2006). Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians. J. Bone Miner. Metab. 24, 36-41.
