A Comparison of the Sensitivity of the BayesC and Genomic Best Linear Unbiased Prediction(GBLUP) Methods of Estimating Genomic Breeding Values under Different Quantitative Trait Locus(QTL) Model Assumptions
الموضوعات :
M. Shirali
1
(Department of Animal Science, Faculty ofAgriculture and Natural Resources, University of Tehran, Karaj, Iran)
S.R. Miraei-Ashtiani
2
(Department of Animal Science, Faculty ofAgriculture and Natural Resources, University of Tehran, Karaj, Iran)
A. Pakdel
3
(Department of Animal Science, Faculty ofAgriculture and Natural Resources, University of Tehran, Karaj, Iran)
C. Haley
4
(Division of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, United Kingdom)
P. Navarro
5
(Medical Research Council Human Genetics (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom)
R. Pong-Wong
6
(Division of Genetics and Genomics, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, United Kingdom)
الکلمات المفتاحية: BayesC, breeding value, GBLUP, number of QTL, QTL effect distribution,
ملخص المقالة :
The objective of this study was to compare the accuracy of estimating and predicting breeding values using two diverse approaches, GBLUP and BayesC, using simulated data under different quantitative trait locus(QTL) effect distributions. Data were simulated with three different distributions for the QTL effect which were uniform, normal and gamma (1.66, 0.4). The number of QTL was assumed to be either 5, 10 or 20. In total, 9 different scenarios were generated to compare the markers estimated breeding values obtained from these scenarios using t-tests. In comparisons between GBLUP and BayesC within different scenarios for a trait of interest, the genomic estimated breeding values produced and the true breeding values in a training set were highly correlated (r>0.80), despite diverse assumptions and distributions. BayesC produced more accurate estimations than GBLUP in most simulated traits. In all scenarios, GBLUP had a consistently high accuracy independent of different distributions of QTL effects and at all numbers of QTL. BayesC produced estimates with higher accuracies in traits influenced by a low number of QTL and with gamma QTL effects distribution. In conclusion, GBLUP and BayesC had persistent high accuracies in all scenarios, although BayesC performed better in traits with low numbers of QTL and a Gamma effect distribution.
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