Mild and efficient solvent-free tetrahydropyranylation (THP) of alcohols catalyzed by reusable acidic ionic liquid [Et3N(CH2)4SO3H][OTs]
الموضوعات : Iranian Journal of Catalysis
Abdol Reza Hajipour
1
(Department of Pharmacology, University of Wisconsin Med. Sch., 1300 University Avenue, Madison, WI 53706-1532, USA
Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran.)
Ghobad Azizi
2
(Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran.)
الکلمات المفتاحية: Protection, Tetrahydropyranylation, Solvent-free reaction, Reusable acidic ionic liquid,
ملخص المقالة :
A variety of alcohols readily add to 3,4-dihydro-2H-pyran under solvent free conditions in the presence of catalytic amount of acidic ionic liquid [Et3N(CH2)4SO3H][OTs] to afford the corresponding tetrahydropyranyl ethers in good to excellent yields at room temperature. The use of this procedure allows easy separation of the desired products from ionic liquid and recycling the ionic liquid. Some of the major advantages of this procedure are nonaqueous work-up, very good yields, catalytic amount of catalyst and reusability of ionic liquid.
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