An efficient one-pot synthesis of α-amino nitriles using ecofriendly Lewis-acidic ionic liquid choline chloride.2ZnCl2

الموضوعات : Iranian Journal of Catalysis

Abdol Hajipour ¹ (Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA.)
Ifa Mahboobi Dehbane ² (Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran.)

تاريخ الإرسال : 23 الإثنين , جمادى الثانية, 1433 تاريخ التأكيد : 09 السبت , صفر, 1434 تاريخ الإصدار : 17 السبت , محرم, 1434

الکلمات المفتاحية: α-Amino nitriles, Strecker reaction, Trimethylsilylcyanide, Choline chloride,

ملخص المقالة :

α-Amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes (or ketones), aniline, and trimethylsilyl cyanide using a catalytic amount of choline chloride.2ZnCl2 as a bio Lewis acidic ionic liquid. Mild Lewis acidic characteristic of this ionic liquid allows efficient synthesis of α-amino nitriles from acid sensitive aldehydes.

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