Synthesis of 5-amino-1-aryl-4-cyanoimidazoles from formamidines under solvent-free condition
الموضوعات : Iranian Journal of CatalysisAsieh Yahyazadeh 1 , Farhad Shirini 2 , Fatamah Tavakoli 3
1 - Department of Chemistry, University of Guilan, P.O. Box 41335-1914, Rasht, I.R. Iran.
2 - Department of Chemistry, University of Guilan, P.O. Box 41335-1914, Rasht, I.R. Iran.
3 - Department of Chemistry, University of Guilan, P.O. Box 41335-1914, Rasht, I.R. Iran.
الکلمات المفتاحية: Heterogeneous catalyst, Silica sulfuric acid, Imidate, Amidine, Aiaminomaleonitrile, Cyanoimidazole,
ملخص المقالة :
The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine 2 cyclize in solvent-free conditions and in the presence of a base to give a 5-amino-1-aryl-4-cyanoimidazoles 3. Silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparation of amidines 2 from formimidate 1 through reaction with aromatic amines at room temperature and in good to excellent yields. All these derivatives were fully characterized by spectroscopic data.
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