Morpholinium glycolate as an efficient and reusable catalyst for the synthesis of bis(pyrazol-5-ol) derivatives under solvent-free conditions
الموضوعات : Iranian Journal of Catalysis
Mohd Akmal Shaikh
1
(Post Graduate and Research Centre, Maulana Azad College, Aurangabad-431001(M.S), India.)
Mazahar Farooqui
2
(Dr. Rafiq Zakaria College for Women, Aurangabad-431001 (M.S), India.)
Syed Abed
3
(Government College of Arts and Science, Aurangabad- 431001 (M.S), India.)
الکلمات المفتاحية: Homogeneous catalyst, Ionic Liquids, Bis(pyrazol-5-ol)s, Morpholinium glycolate,
ملخص المقالة :
In this paper, an environmentally benign access to synthesize Bis(pyrazol-5-ol) derivatives was developed through the one pot pseudo five component condensation reaction of phenyl hydrazine with ethyl acetoacetate, and different aryl/heteroaryl aldehydes using morpholinium glycolate as the homogeneous reusable catalyst under solvent-free conditions at 80 °C. Further, the ionic liquid was prepared and characterized by FT-IR, 1HNMR, 13CNMR and TG-DTG techniques. The present synthetic protocol offers excellent yields of the products, short reaction times, clean and simple work up, reusability of catalyst up to five runs, a significant reduction in cost, and eco-efficient alternative to the existing methods.
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