SFHS: Reusable catalyst for the synthesis of polyhydroquinoline derivatives and its molecular docking studies against tyrosine protein kinase

الموضوعات : Iranian Journal of Catalysis

Amit Waghmare ¹ , Tushar Patil ² , Kailash Kadam ³ , Shivaji Pandit ⁴

1 - Department of Chemistry, PVP College, Pravaranagar, Tal. Rahata-413 713
2 - Department of Biotechnology,PVP College, Pravaranagar, Tal.Rahata-413 713
3 - Department of Chemistry, PVP College, Pravaranagar, Tal.Rahata-413 713
4 - Department of Chemistry, PVP College, Pravaranagar, Tal.Rahata-413 713

تاريخ الإرسال : 04 الإثنين , شعبان, 1435 تاريخ التأكيد : 06 الخميس , محرم, 1436 تاريخ الإصدار : 10 الأحد , جمادى الأولى, 1436

الکلمات المفتاحية: Multicomponent reaction, Polyhydroquinoline derivatives, Silica supported ferric hydrogen sulphate, Molecular docking,

ملخص المقالة :

An efficient synthesis of polyhydroquinoline derivatives is achieved via Hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of SFHS in ethanol. This method gives remarkable advantages such as shorter reaction time, simple workup procedure and good to excellent yields. Furthermore the catalyst can be recovered conveniently and reused efficiently. To analyze potential anticancer activity, synthesized derivatives were docked to tyrosine protein kinase (1YJ) against 4ST and PTR binding sites.

المصادر:

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