Multicomponent preparation of highly functionalized piperidines using FeCl3.6H2O as an efficient catalyst
الموضوعات : Iranian Journal of Catalysis
Jasem Aboonajmi
1
(Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.)
Malek Taher Maghsoodlou
2
(Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran.)
Nourallah Hazeri
3
(Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.)
Mojtaba Lashkari
4
(Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, Iran)
Mohyeddin Safarzaei
5
(Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.)
Moheb Shirzaei
6
(Department of Chemistry, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran.)
الکلمات المفتاحية: Aldehyde, Multicomponent, Functionalized piperidine, β-Keto ester,
ملخص المقالة :
FeCl3.6H2O was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in EtOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. The structures of all compounds were characterized by comparison of their IR and NMR spectra with authentic samples. Also, the relative stereochemistry of these piperidines has been confirmed by single X-ray crystallography analysis in previously reported literature. Starting materials with electron-deficient or electron-releasing groups were reacted efficiently.
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