Rosa foetida Herrm. flowers as a future natural antibacterial agent against the main cause of skin burn wound infections, Pseudomonas aeroginosa.
الموضوعات : مجله گیاهان داروییمائده رزقی 1 , سید رضا حسینی دوست 2 , ژینوس عسگرپناه 3
1 - گروه داروسازی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS)
2 - گروه میکروبیولوژی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS)
3 - گروه داروسازی، دانشکده داروسازی، واحد علوم دارویی، دانشگاه آزاد اسلامی، تهران - ایران (IAUPS)
الکلمات المفتاحية: Antibacterial, Pseudomonas aeruginosa, Rosa foetida, Skin burn wounds,
ملخص المقالة :
Background & Aim:Belongs to Rosaecea family, Rosa foetida is one the Persian native plants which has not been investigated biologically. As it is traditionally used topically as poultice to treat infectious skin burns, the present paper focused on the assessment of the antibacterial activities of different extracts of R. foetida flowers against the main cause of skin burn wounds infections, Pseudomonas aeruginosa. Experimental: The antibacterial activity and MIC value determination were investigated by cup plate method and micro plate dilution method respectively. Results: All R. foetid extracts had inhibition activity on the growth of P. aeruginosa of which the aqueous and methanol extracts exhibited the strongest activities. Inhibition zone diameter and MIC values of the concentration of 125 mg/ml of both extracts were found to be somehow the same as those of the standard drug, Imipenem/Cilastatin (8/8 μg/ml). Recommended applications/industries: Results demonstrated that the plant is effective against the standard and pathogenic strains of P. aeruginosa and could be a potential source of effective natural antibacterial compounds to be applied in further phytochemical and invivo biological studies.
Weinstein, R.A., Mayhall, C.G. 2003. The Epidemiology of Burn Wound Infections: Then and Now. Clin Infect Dis., 37 (4): 543-550.
Sutter, V.L., Hurst, V. 1966. Sources of Pseudomonas aeruginosa Infection in burns: Study of wound and rectal cultures with phage typing. Annal Surg., 163(4): 597-602.
Kominos, S.D., Charles, E. 1972. Mode of transmission of Pseudomonas aeruginosa in a burn unit and an intensive care unit in a general hospital. Appl Environ Microbiol., 23(2): 309-312.
Eckert, R., Brady, K.M., Greenberg, E.P., Qi, F., Yarbrough, D.K., He, J., McHardy, I., Anderson, M.H., Shi, W. 2006. Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and Tobramycin. Antimicrob Agents Chemother., 50(11): 3833-3838.
Rastegar Lari, A., Bahrami Honar, H., Alaghehbandan, R. 1998. Pseudomonas infections in Tohid Burn Center, Iran. Burns., 24(7): 637-641.
Ranjbar, R., Owlia, P., Saderi, H., Mansouri, S., Jonaidi-Jafari, N., Izadi, M., Farshad, S., Arjomandzadegan, M. 2011. Characterization of Pseudomonas aeruginosa strains isolated from burned patients hospitalized in a major burn center in Tehran, Iran. Acta Med Iran., 49(10): 675-679.
Amin, G. 2005. Popular Medicinal Plants of Iran. Tehran University of Medical Sciences Publishing. Tehran, Iran, pp 232.
Mahmood, N., Piacente, S., Pizza, C., Burke, A., Khan, A.I., Hay, A.J. 1996. The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena. Biochem. Biophys. Res. Comm., 229: 73-79.
Brinkworth, R.I., Stoermer, M.J., Fairlie, D.P. 1992. Flavones are inhibitors of HIV-1 protease. Biochem. Biophys. Res. Comm., 188: 631-637.
Frederick, C., Wagner, A., Morvillo, N. 2002. Randomly amplified polymorphic and DNA (RAPD) analysis of the musk roses (Rosa moschata). Prac. Fla. State Hort. Soc., 115: 117-119.
Loghmani-Khouzani, H., SabziFini, O., Safari, J. 2007. Essential oil composition of Rosa damascena Mill cultivated in central Iran. ScientiaIranica., 14(4): 316-319.
Ercisli, S. 2007. Chemical composition of fruits in some Rose (Rosa spp.) species. Food Chem., 104: 379-384.
Forsyth, H.K. 2007. The Constant Gardener: A Botanical Bible. The Miegunyah Press. Carlton, Australia, pp 150.
Asgarpanah, J., Ziarati, P., Safialdinardebily, M. 2014. The volatile oil composition of Rosa foetida Herrm. flowers growing wild in Kurdistan province (Iran). J. Essent Oil Bear Plants., 17 (1): 169 – 172.
Fazly-Bazzaz, B.S., Khajehkaramadin, M., Shokooheizadeh, H.R. 2005. Antibacterial activity of Rheum ribes extract obtained from various plant parts against clinical isolates of Gram-negative pathogens. Iran J Pharm Res., 2: 87-91.
Mehregan, H., Mojab, F., Pakdaman, S.H., Poursaeed, M. 2008. Antibacterial activity of Thymus pubescence methanolic extract. Iran J Pharm Res., 7(4): 291-295.
Tambekar, D.H., Mankar, S.S. 2006. Studies on antimicrobial spectrum of Rose petals against bacterial pathogens. Asian J Microbiol Biotechnol Environ Sci., 8(2): 367-372.
Zhang, W., Abdel-Rahman, F.H., Saleh, M.A. 2011. Natural resistance of rose petals to microbial attack. J Environ Sci Health B., 46(5): 381-393.
Velioglu, Y.S., Mazza, G. 1991. Characterization of flavonoids in petals of Rosa damascena by HPLC and spectral analysis. J Agric Food Chem., 39 (3): 463–467.
Katsumoto, Y., Fukuchi-Mizutani, M., Fukui, Y., Brugliera, F., Holton, T.A., Karan, M., Nakamura, N., Yonekura-Sakakibara, K., Togami, J., Pigeaire, A., Tao, G.Q., Nehra, N.S., Lu, C.Y., Dyson, B.K., Tsuda, S., Ashikari, T., Kusumi, T., Mason, J.G., Tanaka, Y. 2007. Engineering of the Rose Flavonoid Biosynthetic Pathway Successfully Generated Blue-Hued Flowers Accumulating Delphinidin. Plant Cell Physiol., 48(11): 1589-1600.
