The effect of Policosanol on decrease of cholesterol, triglyceride and the other lipid metabolite levels in blood of Wistar rats
الموضوعات : مجله گیاهان داروییفاطمه فروهی 1 , منصور امرایی 2 , هادی زمانی 3
1 - گروه میکروبیولوژی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد شهر قدس، تهران، ایران؛
2 - گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران؛
3 - گروه زیست شناسی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد شهر قدس، تهران، ایران؛
الکلمات المفتاحية: Cholesterol, Triglyceride, LDL-C, Policosanal, HDL-C,
ملخص المقالة :
Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats.Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative control group (n=8) that had normal diet, positive control and experimental groups I and II (n=8) with high cholesterol diet of 2% cholestroled, and respectively they received placebo and policosanol with concentrations 0.25 and 0.5 mg/day. After four weeks, following the treatment of animals and bloodletting, the biochemical traits such as cholesterol biochemical, triglyceride, and LDL-C and HDL-C factors were measured.Results & Discussion: The results showed that in experimental group (I) there was a significant decrease (p<0.05) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.05) in HDL-C compared with control group. In experimental group II, there also was a significant decrease (p<0.01) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.01) in HDL-C compared with control group.Industrial and practical recommendations: Policosanol can be an effective component in decreasing the rate of cholesterol, LDL-C and triglyceride and increasing HDL-C.
Alawi, A., Thomas, A., David, M. and Richard, H. 2008. Statin, low-density lipoprotein cholesterol, and risk factor of cancer. JAM Cell Cardiol., 52: 1141-1147.
Carling, D., Zammit, V.A. and Hardie, D.J. 2000. A common bicyclic protein kinase cascade in activates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett., 223: 217-222.
Sing D.K., Li L., and Porter, T.D. 2006. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-Kinase. Journal of Pharmacology and Experimental Therapeutics., 318(3): 1020-1026.
Dullens, S., Mensik, R., Bragt, M., Kies, A. and Plat, J. 2008. Effects of emulsified policosanol with different chain lenghs on cholesterol metabolism in heterozygous LDL receptor-deficient mice. Journal of Lipid Research., 49: 790-796.
Dulin, M., Hatcher, L., Sasser, H. and Barringer, T. 2006. Policosanol is ineffective in the treatment of hypercholesterolemia: a randomized controlled trial. Journal of Clinical Nutrition., 84(6): 1543-1548.
Frank, J.S., Watson, A.D. and Edwards, P.A. 1995. Panthogenesis of atherosclerosis. American Journal of Cardiology., 76(9): 18-23.
Hansson, G.K. 1996. Immuno responses in atherosclerosis In: Hansson G.K, Hibby Pedton. Immuno functions of the vasel well. Amesterdam: Harwood. pp. 322-324.
Hennekens, C.H. and Gasiano, J.M. 1993. Antioxodants and heart disease: epidemiology and clinical evidence. Clinical Cardiology., 16: 110-115.
Ho Ng, C., Leung, K. and Chen, Z. 2005. Policosanol has no antioxidant activity in human low-density lipoprotein but increases excretion of bile acids in Hamsters. Journal of Agriculture and Food Chemistry., 53(16): 6289-6293.
Libby, P., Hansson, G.K. 1991. Involvement of the immune system in human atherosclerosis: current knowledge and unanswered question. Laboratory Investigation., 46: 5-15.
McCarty, M.F. 2002. Policosanol safely dow-regulates HMG-CoA reductase-potential as a component of the Esselstyn regimen. Medical Hypotheses., 59: 268-279.
Menendez, R., Amor, A.M., Rodeiro, I., Gonzalez, R.M., Gonzalez, P.C., Alfonso, J.L. and Mas, R. 2001. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Archives of Medical Research., 32: 8-12.
Menendez, R., Mas, R., Amor, A.M., Gonzalez, R.M., Fernandez, J.C., Rodeiro, I., Zayas, M. and Jimenez, S. 2006. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. Journal of Clinical Pharmacology., 50(3): 255-262.
Noa, M., Más, R. and Mesa, R. 1998. Effect of policosanol on intimal thickening in rabbit cuffed carotid artery. International Journal of Cardiology., 67:125–132.
Sing, H., Derwas, N. and Poulos, A. 1987. Very long chain fatty acid beta-oxidation by rat liver mitochondria and peroxisoma. Archives of Biochemistry and Biophysics., 310: 382-390.
Wang, Y.W., Jones, P.J., Pischel, I. and Fairow, C. 2003. Effect of policosanol and phytosterols on lipid levels cholesterol biosynthesis in hamsters. Lipids., 38: 165-170.
Zaman, A., Helft, G., Worthley, S. and Badimón, J. 2009. The role of plaque rupture and thrombosis in coronary artery disease. Atherosclerosi., 49: 251–266.
