Chemical composition and anti-inflamatory, anti-nociceptive and antipyretic activity of rhizome essential oil of Globba sessiliflora Sims. collected from Garhwal region of Uttarakhand

الموضوعات : مجله گیاهان دارویی

راوندرا کومار ¹ (Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture & Technology, Pantnagar, U.S. Nagar, Uttarakhand, India)
پراکاش ام ² (Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture & Technology, Pantnagar, U.S. Nagar, Uttarakhand, India)
پانت آنیل ³ (Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture & Technology, Pantnagar, U.S. Nagar, Uttarakhand, India)
کومار ماهش ⁴ (Department of Vet. Epidemiology and Preventive Medicine, College of Veterinary & Animal Sciences. G.B. Pant University of Agriculture & Technology, Pantnagar, U.S. Nagar, Uttarakhand, India)
ایسیدورو والاری ⁵ (Institute of Chemistry, Białystok University, Division of Environmental Chemistry, UL. Hurtowa 1,15-399, Białystok, Poland)
اسزپانیاک لچ ⁶ (Institute of Chemistry, Białystok University, Division of Environmental Chemistry, UL. Hurtowa 1,15-399, Białystok, Poland)

تاريخ الإرسال : 19 الأحد , شوال, 1437 تاريخ التأكيد : 17 الجمعة , ربيع الأول, 1438 تاريخ الإصدار : 22 الثلاثاء , جمادى الثانية, 1438

الکلمات المفتاحية: Essential oil, Globba sessiliflora Sims, Zingiberaceae, Anti-inflamatory, Anti-nociceptive, Antipyretic activity, β-eudesmol,

ملخص المقالة :

Background & Aim:Family Zingiberaceae is worldwide in distribution. Plants of the zingiberaceae family are used in traditional herbal folk medicine besides their uses in spices, cosmetic, ornamental, food preservatives etc. In Uttarakhand the herbs grow from sub-tropical to temperate region. Globba sessiliflora Simsrhizomes were collected at maturity stage in November from Garhwal region of Uttarakhand, India. In present communication the medicinal use of various zingiberaceous herb provoked us to study the chemical diversity and pharmacological activity determination of this important traditional herb. Experimental: The essential oil was extracted using hydrodistillation method and analyzed by GC-MS. Anti-inflamatory, anti-nociceptive and antipyretic activities of essential oil were experimently determined using mice model. Results: The major compounds identified were β-eudesmol (27.6%), (E)-β-caryophyllene (24.3%), α-humulene (3.0%), (6E)-nerolidol (4.1%), caryophyllene oxide (9.7%), γ-eudesmol (6.4%) and τ-muurolol (8.3%) besides other minor constituents. Essential oil of G. sessiliflora rhizome showed good anti-inflamatory, anti-nociceptive and antipyretic activities at the dose level of 100 mg/kg body weight. The oral administration of the essential oil exhibited no toxicity at 400, 600 and 800 mg/kg b.wt. concentration. Ibuprofen, indomthacin and paracetamol were used as standard drugs for comparison.Recommended applications/industries: G. sessiliflora essential oil can be used as herbal remedy for its nontoxicityanti-inflamatory, anti-nociceptive and antipyretic activities.

المصادر:

Abelson, K., 2005. Acetylcholine in spinal pain modulation: An in vivo study in the rat. Digital Comprehensive Summaries of Upsulla Dissertations from the faculty of Medicine. 19. 55pp. Uppsula. ISBN 91-554-6178-6.

    Adams, R.P., 1995. Identification of essential oil components by gas chromatography,        mass Spectrometry. Allured Publishing Corporation, Carol Stream, Illinois, USA.

     Albert, D., Z¨undorf, I., Dingermann, T., M¨uller, W. E., Steinhilber, D., Werz, O., 2002. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochemical Pharmacology. 64,1767–1775.

Alberto, M.R., Zampini, I.C., Isla, M.I.,2009. Inhibition of cyclooxygenase activity by standardized hydroalcoholic extracts of four Asteraceae species from the Argentine Puna. Braz J Med Biol Res. 42(9),787-90.

Almeida, T. I., Roizenblatl, S. and Tufik, S., 2004.Afferent pain pathways: a neuroanatomical review. Brain Research, 1000,40-56.

Babu, C.R., 1977. Herbaceous flora of Dehradun. CSIR, New Delhi, pp 502.

Besson, J. M., Chaouch, A., 1987.Peripheral and spinal mechanisms of Nociception. Physiology Reviews, 67,67-186.

Brzezinska-Slebodzinska, E., 2001. Fever induced oxidative stress. The effect on thyroid status and the 5'-mono deiodinase activity, protective role of selenium vitamin. Journal of Physiology and Pharmacology. 52,275-284.

Chattopadhyay, D., Arunachalam, G., Ghosh, L., 2005. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands. J Pharm Phar Sci.8 (3), 558-64.

Chatterjee, G. K., Pal., S. P., 1984. Search for anti-inflammatory agents from Indian Medicinal Plants-A review. Indian Drugs. 21, 413.

Di Rosa, M., Willoughby, D.A., 1971. Screens for anti-inflammatory drugs. Journal of Pharmacy and Pharmacology. 23,297-298.

Endress, P.K., 1994. Diversity and evolutionary biology of tropical flowers. Cambridge  University Press, Cambridge.

Farnsworth, N. R. 1989.Screening plants for new medicines. In Wilson E.O. Editor, Biodiversity, Part II, National Academy Press, Washington, pp 83-97.

Hussain, A., Virmani, O.P., Popli, S.P., Misra, L.N., Gupta, M.M., 1992. Dictionary of Indian medicinal plants. Director, Central Institute of Medicinal and Aromatic Plants, Lucknow. 161-162.

Jaganath, I.B., Ng, L.T. 2000. Herbs: The green Pharmacy of Malaysia. Vinpress Sdn. Bhd. Malaysia Agriculture and Research and Development Institute. 95-99.

Karthikeyan, S., Jain, S.K., Nayar, M.P., Sanjappa, M., 1989. Floral Indicae Enumeratio:   Monocotyledonae. Botanical survey of India, Calcutta, pp 293-294.

Kumar, R., Prakash, Om., Pant, A.K.,  Isidorov, Valery A., Mathela., C.S. 2012.Chemical composition, antioxidant and myorelaxant activity of essential oils of Globba sessiliflora Sims. 24(4),385-391.

Langerman, L., Zakowski, M.I., Piskoun, B.,  Grant, G.J., 1995. Hot plate versus tail-flick: Evaluation of acute tolerance to continuous morphine infusion in rat model. Journal of Pharmacological and Toxicological Methods. 34,23-27.

Mattison, N., Trimple, A. G., Larsen, I., 1998. New drug development in the United States, 1963 through 1994. Clinical Pharmacology Therapeutics Journal. 43, 290-301.

Maria G. M., 2010. Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review.Molecules.15, 9252-9287.

OJ, Oh., H. Y. Min, Lee, S.K.,2007. Inhibition of inducible prostaglandin E2 production and

cyclooxygenase-2 expression by curdione from Curcuma zedoaria. Arch Pharm Res. 30(10),1236-9.574.

423, OECD/OCDE, 2001. Acute oral toxicity-Acute toxic class method. Guideline for the testing of chemicals, guidance document on acute toxic class method.

Rao, R.R., Babu, R.M., Rao, M.R.V., Babu, M.G.V. 1997. Studies on antipyretic, analgesic and hypoglycaemic activities of root of Gynandropsis gynandra Linn. Indian Drugs. 34,12:690- 694.

Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., 1994.  Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proceedings of the National Academy of Sciences. 91,12013-12017.

Smith, J.B., Willis, A.L., 1971. Aspirin selectivity inhibition prostaglandin production in human platelets. Nature New Biology.231,235-239.

Strachey, L., 1979. Catalogue of plants of Kumaun and of adjacent portion of Garhwal and Tibbet. Revised by Duthie JE pp 269, 1918, Reprint in 1974 periodicals publication Dehradun

Shailasree, S., Ruma, K., Kini, K.R., Niranjana, S.R., Prakash, H.S., 2012. Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India. Phcog Commn. 2,2-12.

Saper, C.B., Breder, C.D., 1994.  The neurologic basis of fever. N Engl J Med, 330(26), 1880-1886.

Takano, A., Okada, H., 2003. Taxanomy of Globba (Zingiberaceae) in Sumatra, Indonesia. Syst Bot 28,524-546

Tapiero, H., Ba, G. N., Couvreur, P., Tew, K. D., 2002. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomedicineand Pharmacotherapy. 56,215–222.

Uniyal, B.P., Sharma, J.R., Chouddhery, U., Singh, D.K., 2007. Flowering plants of Uttarakhand (a checklist). Bishen Singh, Mahendra Pal Singh, Dehradun, pp 235.

Vanden Worm, E., Beukelman, C. J., Vanden Berg, A. J. J., Kores, B. H., Labadie, R. P., Van Dijk, H. 2001. Effects of methoxylation of apocynin and analogson the inhibition of reactive oxygen species production by stimulated human neutrophils. European Journal of Pharmacology. 433,225–230.

Vinegar, R., Schreiber, W., Hugo, R., 1969., Biphasic development of carrageenan edema in rates.   Journal of Pharmacology and Experimental Therapeutics. 166,1:96-103.

Winter, C.A., Risley, E.A., Nuss, G.W., 1962. Carrageenan-induced edema in hind paws of the rats as an assay for antiinflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine.111,544-547.