Effect of hydroalcoholic extract of Nigella sativa L. on the immune system and blood protein components in mice
الموضوعات : مجله گیاهان دارویی
مهرداد مدرسی
1
(
دانشیار گروه علوم دامی، دانشکده کشاورزی، دانشگاه آزاد اسلامی، واحد خوراسگان (اصفهان)، اصفهان، ایران
)
الکلمات المفتاحية: immune system, Mice, Nigella sativa L, protein electrophoresis,
ملخص المقالة :
Background: Black seed (Nigella sativa L.) in traditional medicine is well known that the chemical composition of the immune system with many applications in traditional medicine to fight the infection. This study investigated the effect of the plant's role in the immune system and blood protein.Experimental: In this study male mice of Balb/c strain were divided into four groups tested. Control and experimental groups 1, 2 and 3, respectively, 50, 100 and 200 dose mg/Kg of the extract of Nigella sativa seed hydro alcoholic extract in 20 days and injected intraperitoneally received. At the end of the experiment, blood was taken for white cell count and blood protein electrophoresis was used. The data obtained with the SPSS software.Results and discussion: Studies suggest that the extracts of Nigella sativa in the groups are able to increase white blood cell count, protein and albumin, alpha 1 and 2 and the A/G.Industrial/Practical recommendation: According to the survey results appear in the pharmaceutical industry play an effective role in strengthening the immune system of Nigella sativa and, play in this context can be used as a medicinal plant use.
دشتی نژاد، و همکاران. 1372 . بیوشیمی بالینی (دیوید سون). چاپ اول . انتشارات آوا . ص 218-213 و 225.
عطار. 1387. گیاهان دارویی سینا. ص: 22
ملک نیا، ن.، شهبازی، پ.، کریم زاده ، ح.، رفتاری ، ع.، ابطحی، م. 1377. بیوشیمی هارپر (ترجمه) . جلد دوم. انتشارات شهرآب.
Celermajer, D.S. and Sorensen, K.E. 1994. Aging is associated with endothelial dysfunction in healthy men years before the age related decline in women. Journal of the American College of Cardiology, 24: 471-476.
Dugenci, S.K., Arda, N. and Candan, A. 2003. Some medicinal plants as immunostimulant for fish. Journal of Ethnopharmacolology, 88(1): 99-106.
Jepson, R.G., Kleijnen, J. and Leng, G.C. 2000. Garlic for peripheral arterial occlusive disease. Cochrane Database Of Systematic Reviews, 2: 1469-1493.
Jesse, J., Mohseni, M. and Shah, N. 1997. Medical attributes of Allium sativum (garlic). American Journal of Botany, 81: 89-95.
Koscicnly, J., Klussendorf, D. and Lateza, R. 1999. The antitrombic effect of garlic. Atherosclerosis, 144: 237-249.
Lau, B.H. and Adetumbi, M.A. 1983. Allium sativum and atherosclerosis: A review, 3: 119-128.
Merat, A. and Fallahzadeh, M. 1996. Effect of garlic on some blood lipids and hmgoca reductase activity. Iranian Journal Medical Science, 21: 141 -146.
Paradise, L.A. Black cumin seed extract. [cited 2008]. Available from: URL: http://www.answers.com/ topic/black-cumin-seed-extract.
Pizzorno, O. and Murrany, 1995. A Textbook of Natural Medicine. Seattle, Bastyr.
Santos A, 1995. Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well being. British Journal of Clinical Research, 6: 91-106.
Vahdati Mashhadian, N., Rakhshandeh, H. and Omidi, A. 2005. An investigation on LD50 and subacutehepatic toxicity of Nigella sativa seed extract in mice. Department of Pharmacology, Mashhad University of Medical Sciences, 60 (7): 544-547.
