Investigating effect of chamomile hydroalcoholic extract on movement disorders in the animal model of Parkinson's disease
الموضوعات : مجله گیاهان داروییشهربانو عالمی رستمی 1 , مریم رفیعی راد 2
1 - Department of Biology,Islamic Azad Univercity,Gomishan center , Gorgan Branch,Gorgan Iran
2 - Department of Biology, faculty of Sciences, Islamic Azad University, Izeh branch, Izeh-Iran
الکلمات المفتاحية: Rats, Movement disorder, Chamomile extract, Parkinson's disease (PD),
ملخص المقالة :
Background & Aim:Parkinson's disease (PD) is a kind of disorder in the nervous system, which is characterized with multiple movement disorders. Factors such as oxidative stress are the most important causes for the degeneration of dopaminergic neurons in the substantia nigra and occurrence of Parkinson's disease. Thus, medications that have antioxidant functions could be an interesting target for treating the movement disorders caused by Parkinson's disease. Chamomile is the natural source of antioxidants. Experimental: In this study, 50 adult male Wistar rats were randomly divided into control and Parkinson's groups with 10 rats along with 3 Parkinson's groups, which received chamomile extract by gastric gavage method and doses of 5, 10, and 50 mg/kg once per day for 14 days. Also, 8 μg of 6-hydroxydopamine (6-OHDA) neurotoxin in 2 μl saline containing 1% ascorbic acid was injected into medial forebrain bundle (MFB) of the left hemisphere of the brain of the rats to induce Parkinson's disease. Results were presented as mean ± SD, one-way analysis of variance, and Tukey's post-hoc test. Results:Following subcutaneous injection 2.5 mg/kg apomorphine 14 days after injury with 6-OHDA in MFB of left brain, animals were rotated 360 degrees to the right by 10 Recommended applications/industries: Probably because of its strong antioxidant effect and interference with the activity of movement pathway receptors, chamomile extract can be used to improve and reduce the movement disorders of Parkinson's disease in addition to pharmacotherapy.
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