Dracocephalum kotschyi Boiss.: An Iranian endemic medicinal plant; A review
الموضوعات : مجله گیاهان داروییالهام فروزنده 1 , حسینعلی اسدی قارنه 2
1 - گروه باغبانی ، دانشکده کشاورزی ، واحد اصفهان (خوراسگان) ، دانشگاه آزاد اسلامی ، اصفهان ، ایران
2 - گروه باغبانی ، دانشکده کشاورزی ، واحد اصفهان (خوراسگان) ، دانشگاه آزاد اسلامی ، اصفهان ، ایران
الکلمات المفتاحية: Dracocephalum kotschyi Boiss, Biochemical compound, Xanthomicrol, Spinal-Z,
ملخص المقالة :
Background & Aim:Iran with about 8000 plant species and 1728 endemic species; is one of the most important sources of medicinal plants. Dracocephalum kotschyi Boiss, belonging to the Lamiaceae family, is one of the endemic plants in Iran. It grows in regions of Chaharmahal and Bakhtiari, Esfahan, Gorgan, Mazandaran, Hamedan, Kermanshah, Lorestan, Tehran, Fars and the northern heights of Semnan. In this review, the botany, traditional uses, phytochemical and pharmacological properties of Dracocephalum kotschyi Boiss are discussed.Experimental: In the current review keywords including DracocephalumkotschyiBoiss. and medicinal properties were searched in scientific websites such as PubMed, Science Direct and Google Scholar to compile the botanical and medicinal properties of Dracocephalum kotschyi Boiss.Results: According to the literature review, Dracocephalum kotschyi Boiss. with high concentration of essential oil, flavonoids and other secondary metabolites is a valuable endemic plant. It has been shown immunomodulatory, anti-hyperlipidemic and anti-spasmodic activities and is effective in treatment of headaches, congestion, and liver disorders. In addition, anti-cancer properties of this plant are related to presence of xanthomicrol and Spinal-Z compounds in the leaves of this plant.Recommended applications/ industries: Dracocephalum kotschyi Boiss. with high amount of biochemical components and pharmacological effects can be used as a valuable herbal drugs. Its cultivation for industrial and pharmaceutical purposes can help to improve the production of anti-cancer drugs in Iran.
Amirghofran, Z., Azadbakht, M. and Karimi, M. 2000. Evaluation of the immunomodulatory effects of five herbal plants. Journal of Ethnopharmacology, 72:157-171.
Asaadi, A. and Khoshnod Yazdi, A. 2010. Study of ecological characters of Dracocephalum kotschyi Bioss. In Bojnourd rangelands. Iranian Journal of Medicinal and Aromatic Plants Research, 26(3): 406-414.
Aziz, Z., Ahmad, A., Setapar, S., Karakucuk, A., Azim, M.M., Lokhat, D., Rafatullah, M., Ganash, M., Kamal, M.A. and Ashraf, G.M. 2018. Essential oils: extraction techniques, pharmaceutical and therapeutic potential - A review. Current drug metabolism, 19(13):1100–1110.
Ben Djemaa, F.G., Bellassoued, K., Zouari, S., El Feki, A. and Ammar, E. 2016. Antioxidant and wound healing activity of Lavandula aspic L. ointment. Journal of Tissue Viability, 25(4):193–200.
Cardia, G., Silva-Filho, S.E., Silva, E.L., Uchida, N.S., Cavalcante, H., Cassarotti, L.L., Salvadego, V., Spironello, R.A., Bersani-Amado, C.A. and Cuman, R. 2018. Effect of Lavender (Lavandula angustifolia) essential oil on acute inflammatory response. Evidence-based Complementary and Alternative Medicine: CAM, 2018(2): 1-10.
Chang, Y.D., Lee, C.H., Song, J.S. and Hwang, J.K. 2009. Several factors affecting on seed germination of Dracocephalum argunen Fischer ex Link. Korean Journal Plant Research, 22: 236-241.
Cho, M., So, I., Chun, J.N. and Jeon, J.H. 2016. The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review). International journal of oncology, 48(5): 1772–1782.
Couture, R., Mora, N., Al Bittar, S., Najih, M., Touaibia, M. and Martin, L.J. 2020. Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells. Cell Biology and Toxicology, 36(1): 31–49.
Crowell, P.L. 1999. Prevention and therapy of cancer by dietary monoterpenes. Journal of Nutrition, 129: 775–778.
Elbashir, S., Devkota, H.P., Wada, M., Kishimoto, N., Moriuchi, M., Shuto, T., Misumi, S., Kai, H. and Watanabe, T. 2018. Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants. BMC Complementary and Alternative Medicine, 18(1): 282.
Fattahi, M., Cusido, M.R., Khojasteh, A., Mercedes, B. and Javier, P. 2014. Xanthomicrol: A comprehensive review of its chemistry, distribution, biosynthesis and pharmacological activity. Mini Reviews in Medicinal Chemistry, 14(9): 725-733.
Fattahi, M., Nazeri, V., Torras Claveria, L. and Sefidkon, F. 2013. Identification and quantification of leaf surface flavonoids in wild-growing populations of Dracocephalum kotschyi by LC–DAD–ESI-MS. Food Chemistry, 141:139-146.
Gadotti, V.M. and Zamponi, G.W. 2019. Anxiolytic effects of the flavonoid luteolin in a mouse model of acute colitis. Molecular brain, 12(1):114.
Gohari, A.R., Saeidnia, S., Matsuo, K., Uchiyama, N., Yagura, T., Ito, M., Kiuchi, F. and Honda, G. 2003. Flavonoid constituents of Dracocephalum kotschyi growing in Iran and their trypanocidal activity. Journal of Natural Medicines, 57(6):250–252.
Guo, Q., Li, F., Duan, Y., Wen, C., Wang, W., Zhang, L., Huang, R. and Yin, Y. 2020. Oxidative stress, nutritional antioxidants and beyond. Science China. Life Sciences, 63(6): 866–874.
Gulcin, I., Mshvildadze, V., Gepdiremen, A. and Elias, R. 2006. Screening of antiradical and antioxidant activity of monodesmosides and crude extract from Leontice smirnowii tuber. Phytomedicine, 13:343–351.
Han, Y., Sun, Z. and Chen, W. 2019. Antimicrobial susceptibility and antibacterial mechanism of limonene against Listeria monocytogenes. Molecules (Basel, Switzerland), 25(1): 33-37.
Hatami, M., Samadi, M. and Khanizadeh, P. 2019. Effect of different treatments on breaking seed dormancy and stimulate germination in dragonhead (Dracocephalum kotschyi Bioss). Iranian Journal of Range and Desert Research, 26(4): 918-931.
Jahanian, F., Ebrahimi, S.A, RahbarRoshandel, N. and Mahmoudian, M. 2005. Xanthomicrol is the main cytotoxic component of Dracocephalum and a potential anti-cancer agent. Phytochemistry, 66(13):1581-1592.
Jalali, A. and Jamzad, Z., 1999. Red data book of Iran. Research Institute of Forests and Rangelands. Tehran: Iran. Pp. 748.
Kamali, M., Khosroyar, S. and Jalilvand, M. 2014. Evaluation of phenolic, flavonoids, anthocyanin contents and antioxidant capacities of different extracts of aerial parts of Dracocephalum kotschyi. Journal of North Khorasan University of Medical Sciences, 6 (3):627-634.
Karimi, A., Rahmani, F., Pirbalouti, A.G. and Mohammadi, M. 2020. Growth, physiological and biochemical traits of sage under the exogenous stimulating and stress factors. Russian Journal of Plant Physiology, 67: 933–944.
Kavvadias, D., Monschein, V., Sand, P., Riederer, P. and Schreier, P. 2003. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Medica, 69(2):113–7.
Kennedy, D., Okello, E., Chazot, P., Howes, M.J., Ohiomokhare, S., Jackson, P., Haskell-Ramsay, C., Khan, J., Forster, J. and Wightman, E. 2018. Volatile terpenes and brain function: investigation of the cognitive and mood effects of Mentha × Piperita L. essential oil with in vitro properties relevant to central nervous system function. Nutrients, 10(8): 1029.
Kiani, S., Shiran, B., Ahmadi, J., Fallahi, H. and Fabrikiourang, S. 2020. Study of proline accumulation and gene expression of P5CS at vegetative and flowering stages of Dracocephalum kotschyi under drought stress. Modern Genetics Journal, 14 (4):345-356.
Kochaki, A. and Sirmainea, G.H. 2000. Physiology of crops. Mashhad University Press.
Kulak, M. 2020. Recurrent drought stress effects on essential oil profile of Lamiaceae plants: An approach regarding stress memory. Industrial Crops and Products, 154: 112695.
Lee, S., Park, Y.R., Kim, S.H., Park, E.J., Kang, M.J., So, I., Chun, J.N. and Jeon, J.H. 2016. Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Medicine, 5(10): 2899–2908.
Mafakheri, S., Hallaj, R. and Aminian, R. 2018. The effect of nutritional treatments on some morphological, physiological, and biochemical characteristics of Dracocephalum kotschyi Bioss. Eco-phytochemical Journal of Medicinal Plants, 5(4): 20-33.
Marostica Junior, M.R., Rocha Silva, T.A.A., Franchi, G.C., Nowill, A., Pastore, G.M. and Hyslop, S. 2009. Antioxidant potential of aroma compounds obtained by limonene biotransformation of orange essential oil. Food Chemistry, 116(1): 8-12.
Monsef-Esfahani, H., Karamkhani, F., Nickavar, B., Abdi, K. and Faramarzi, M. 2007. The volatile constituents of Dracocephalum kotschyi oils. Chemistry of Natural Compounds, 43(1):40–43.
Moradi, H., Ghavam, M. and Tavili, A. 2019. Study of antioxidant activity and some herbal compounds of Dracocephalum kotschyi Bioss. in different ages of growth. Biotechnology reports (Amsterdam, Netherlands), 25: e00408.
MoridiFarimani, M., Mirzania, F., Sonboli, A. and Matloub-Moghaddam, F. 2017. Chemical composition and antibacterial activity of Dracocephalum kotschyi essential oil obtained by microwave extraction and hydro distillation, International Journal of Food Properties, 20(sup1): 306-315.
Mozaffarian, V. 2008. A Dictionary of Iranian Plant Names: Latin, English, Persian, FarhangMo'aser. Pp.740.
Mukhtar, Y.M., Adu-Frimpong, M., Xu, X. and Yu, J. 2018. Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs. Bioscience Reports, 38(6): BSR20181253.
Najafpour-Navaei, M. and Mirza, M. 2007. Comparative survay on the essential oil composition of cultivated and wild Dracocephalum kotschyi. Iranian Journal of Medicinal and Aromatic Plants, 23 (1); 128 – 133.
Nejad-Sadeghi, M., Taji, S. and Goodarznia, I. 2015. Optimization of supercritical carbon dioxide extraction of essential oil from Dracocephalum kotschyi Bioss: An endangered medicinal plant in Iran. Journal of Chromatography A, 1422: 73-81.
Omidbeigi, R. 2018. Production and processing of Medicinal Plants. Vol. 1. Mashhad: Behnashr. Pp.348.
Otroshy, M. and Moradi, K. 2012. Effect of explants and growth regulators on direct organogenesis of Dracocephalum kotschyi Bioss.via tissue culture technique. Journal of Herbal Drugs (An International Journal on Medicinal Herbs), 3(3): 127-134.
Panahi, Y., Saadat, A., Seifi, M., Rajaee, M., Butler, A. E. and Sahebkar, A. 2018. Effects of Spinal-Z in patients with gastroesophageal cancer. Journal of Pharmacopuncture, 21(1): 26–34.
Patle, T.K., Shrivas, K., Kurrey, R., Upadhyay, S., Jangde, R. and Chauhan, R. 2020. Phytochemical screening and determination of phenolics and flavonoids in Dilleniapentagyna using UV-vis and FTIR spectroscopy. Spectrochimica Acta Part A, Molecular and Biomolecular Spectroscopy, 242: 118717.
Pietta, P.G. 2000. Flavonoids as antioxidants. Journal of Natural Products, 63(7): 1035–1042.
Plant, R.M., Dinh, L., Argo, S. and Shah, M. 2019. The Essentials of essential oils. Advances in Pediatrics, 66: 111–122.
Rechinger, K.H. 1986. Flora Iranica: Labiatae, Vol. 150, Akademische Druck- und Verlagsanstalt, Graz. Pp. 218-230.
Romero Rocamora, C., Ramasamy, K., Meng Lim, S., Majeed, A. and Agatonovic-Kustrin, S. 2020. HPTLC based approach for bioassay-guided evaluation of antidiabetic and neuroprotective effects of eight essential oils of the Lamiaceae family plants. Journal of Pharmaceutical and Biomedical Analysis, 178: 112909.
Sadraei, H., Asghari, G., Khanabadi, M. and Minaiyan, M. 2017. Anti-inflammatory effect of apigenin and hydro alcoholic extract of Dracocephalum kotschyi on acetic acid-induced colitis in rats. Research in Pharmaceutical Sciences, 12(4): 322–329.
Sadraei, H., Asghari, G. and Shahverdi, F. 2016. Antidiarrheal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Bioss. And apigenin in mice. Research in Pharmaceutical Sciences, 11(3): 200–209.
Sai, K., Thapa, R., Devkota, H.P. and Joshi, K.R. 2019. Phytochemical screening, free radical scavenging and α-amylase inhibitory activities of selected medicinal plants from Western Nepal. Medicines (Basel, Switzerland), 6(2): 70.
Sajjadi, S.E., Movahedian Attar, A.M. and Yektaian, A. 1998. Antihyperlipidemic effect of hydroalcoholic extract, and polyphenolic fraction from Dracocephalum kotschyi Bioss. Pharmaceu Acta Helvetiae, 73:167-179
Sammar, M., Abu-Farich, B., Rayan, I., Falah, M. and Rayan, A. 2019. Correlation between cytotoxicity in cancer cells and free radical-scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts. Oncology Letters, 18(6): 6563–6571.
Sharma, P., Sharma, S. and Singh, D. 2020. Apigenin reverses behavioral impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutritional Neuroscience, 23(2): 118–127.
Taiz, L. and Zeiger, E. 2010. Plant Physiology. 5th Edition, Sinauer Associates, Inc., Sunderland. pp.782.
Wong, T.Y., Tan, Y.Q., Lin, S. and Leung, L.K. 2017. Apigenin and luteolin display differential hypocholesterolemia mechanisms in mice fed a high-fat diet. Biomedicine & Pharmacotherapy, 96: 1000–1007.
Zargari, A. 1995. Iranian medicinal plants, Tehran University Press, Tehran: Iran.pp. 4272.
Zhang, N. and Yao, L. 2019. Anxiolytic effect of essential oils and their constituents: A review. Journal of Agriculture and Food Chemistry, 67(50):13790-13808.
Zhi, X.N., Yvonne, T.T.K. and PhaikHar, Y. 2020. Comparative analyses on radical scavenging and cytotoxic activity of phenolic and flavonoid content from selected medicinal plants. Natural Product Research, 14:1-6.