Chemical composition of the essential oil from the leaves of Marrubium vulgare L.from Iran

الموضوعات : مجله گیاهان دارویی

احمدرضا گلپرور ¹ (گروه زراعت و اصلاح نباتات، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد اصفهان(خوراسگان)، اصفهان، ایران)
امین هادی پناه ² (گروه باغبانی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران)
علی مهراز مهرابی ³ (گروه اصلاح نباتات، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران)
آرزو آرمین ⁴ (گروه زراعت و اصلاح نباتات، دانشکده کشاورزی، دانشگاه آزاد اسلامی واحد اصفهان(خوراسگان)، اصفهان، ایران)

تاريخ الإرسال : 13 الخميس , محرم, 1436 تاريخ التأكيد : 14 الإثنين , ربيع الأول, 1436 تاريخ الإصدار : 12 الأربعاء , جمادى الثانية, 1436

الکلمات المفتاحية: GC/MS, MarrubuimVulgare L, Chemical constitutes,

ملخص المقالة :

Background & Aim: White horehound (Marrubium vulgare L.) is a perennial medicinal plant of the family Lamiaceae. The aim of this study was to identify of the chemical components of white horehound collected from Isfahan. Experimental: The aerial parts of M. vulgare were collected from (Kamu Mountain) Isfahan province central of Iran, during 2014. The essential oils of samples were obtained by hydro-distillation, and analyzed using gas chromatography–mass spectrometry (GC–MS). Results & Discussion: Results of GC/MS indicated that 44 compounds were identified in the essential oil from the aerial parts of M. vulgare. The major constituents of the essential oil were β-caryophyllene (32.19%), (E)-β-farnesene(11.39%), 1,8-cineole (8.17%) and α-pinene (6.64%).A comparison of our results with different reports, differences in the volatile composition of the plants could be attributed to genetic (genus, species, and ecotype), chemotype, distinct environmental and climatic conditions, seasonal sampling periods, geographic origins, plant populations, vegetative plant phases, and extraction and quantification methods. Industrial and practical recommendations: The biosynthesis of secondary metabolites, although controlled genetically, is strongly affected by the environmental influences of a particular growing region.

المصادر:

Abadi, A. and Hassani, A. 2013. Essential oil composition and antioxidant activity of Marrubiumvulgare L. growing wild in Eastern Algeria. International Letters of Chemistry, Physics and Astronomy., 9(1): 17-24.

Abedi, R., Golparvar, A.R. and Hadipanah, A. 2015. Identification of the essential oils composition from four ecotypes of Menthalongifolia (L.) Huds. growing wild in Isfahan province, Iran. Journal of BioScience and Biotechnology., 4(2): 117-121.

Adams, R.P. 2007. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometery, 4th edition (Allured Publishing Corporation, Carol Stream, IL) 456.

Asadipour, A., Mehrabani, M., Nazeri, V. and Tabarraii, M. 2005. Composition of the essential oil of Marrubiumvulgare L. Ulum-i-Daroei., 2: 77-82.

De Jesus, R.A.P., Cechinel-Filho, V., Oliveira, A.E. and Schlemper, V. 2000. Analysis of the antinociceptive properties of marrubiin isolated from Marrubiumvulgare. Phytomedicine., 7: 111–115.

El Bardai, S., Morel, N., Wibo, M., Fabre, N., Llabres, G., Lyoussi, B. and Quetin-Leclercq, J. 2003. The vasorelaxant activity of marrubenol and marrubiin from Marrubiumvulgare. Planta Med., 69: 75–77.

EL-Hawary, S., EL-Shabrawy, A., Ezzat, S. and ELShibany, F. 2013. Gas chromatography-mass spectrometry analysis, hepatoprotective and antioxidant activities of the essential oils of four Libyan herbs. Journal of Medicinal Plants Research., 7(24): 1746-1753.

Golparvar, A.R., Hadipanah, A. andMehrabi, A.M. 2015. Diversity in chemical composition from two ecotypes of (MenthaLongifolia L.) and (Menthaspicata L. (in Iran climatic conditions. Journal of Biodiversity and Environmental Sciences., 6(4): 26-33.

Hallahan, D.L. 2000. Monoterpenoid biosynthesis in glandular trichomes of labiate plants. Advance Botanical Research., 31: 77-120.

Hamdaoui, B., AidiWannes, W., Marrakchi, M., Ben Brahim, N. and Marzouk, B. 2013. Essential Oil Composition of Two Tunisian Horehound Species: Marrubiumvulgare L. and Marrubiumaschersonii Magnus. Journal of Essential Oil Bearing Plants., 16(5): 608–612.

Hamedeyazdan, S., Fathiazad, F. and Asnaashari, S. 2013. Chemical Composition of the Essential Oil from Marrubiumpersicum C. A. Mey. (Lamiaceae). Pharmaceutical sciences., 19(2): 35-38.

Hellen, K., Stulzer, H.K., Tagliari, M.P., Zampirolo, J.A., Cechinel-Filho, V. and Schlemper, V. 2006. Antioedematogenic effect of marrubiin obtained from Marrubiumvulgare. J. Ethnopharmacol., 108: 379–384.

Kadri, A., Zarai, Z., Bekir, A., Gharsallah, N., Damak, M. and Gdoura, R. 2011. Chemical composition and antioxidant activity of Marrubiumvulgare L. essential oil from Tunisia. African Journal of Biotechnology., 10(19): 3908-3914.

Karioti, A., Skopeliti, M., Tsitsilonis, O., Heilmann, J. and Skaltsa, H. 2007. Cytotoxicity and immunomodulating characteristics of labdanediterpenes from Marrubiumcylleneum and Marrubiumvelutinum. Phytochemistry., 68, 1587–1594.

Khanavi, M., Ghasemian, L., Motlagh, E.H., Hadjiakhoondi, A. and Shafiee, A. 2006. Chemical composition of the essential oils of Marrubiumparvi florum Fisch. & C. A. Mey. And MarrubiumvulgareL. from Iran. Flav. Fragr. J., 20: 324-326.

Meyre-Silva, C., Yunes, R.A., Schlemper, V., Campos-Buzzi, F. and Cechinel-Filho, V. 2005. Analgesic potential of marrubiin derivatives, a bioactive diterpene present in Marrubiumvulgare (Lamiaceae). Farmaco., 60: 321–326.

Mnonopi, N., Levendal, R.A., Davies-Coleman, R.T. and Frost, C.L. 2011. The cardioprotective effects of marrubiin, a diterpenoid found in Leonotisleonurusextracts. J. Ethnopharmacol., 138: 67–75.

Mnonopi, N., Levendal, R.A., Mzilikezi, N. and Frost, C.L. 2012. Marrubiin, a constituent of Leonotusleonurus, alleviates diabetic symptoms. Phytomedicine., 19: 488–493.

Morteza-Semnani, K. and Saeedi, M. 2004. The Essential Oil Composition of Marrubiumastracanicum Jacq. From Iran. J. Essent. Oil Bearing Plants., 7: 239-242.

Mozaffarian, V. 2008. A pictorial dictionary of botany botanical taxonomy Latin-English-French-Germany-Persian. Germany: Koeltz Scientific Books. 522.

Nagy, M. and Svajdlenka, E. 1998. Comparison of Essential Oils from Marrubiumvulgare L. and M. peregrinum L. J. Essent. Oil Res., 10:585-587.

Paula de Olivera, A., Santin, J.R., Lemos, M., Klein, L.C.J., Couto, A.G., Bittencourt, C.M.S., Cechinel, F. and Valdir, F.A. 2011. Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubiumvulgare L. (Lamiaceae). J. Pharm. Pharmacol., 63: 1230–1237.

Said-Al Ahl, H.A.H., Gendy, A.S.H., Mahmoud, A.A. and Mohamed, H.F.Y. 2015. Essential Oil Composition of Marrubiumvulgare L. Cultivated in Egypt. International Journal of Plant Research.,1(4): 138-141.

Salama, M.M., Taher, E. E. and El-Bahy, M.M. 2012. Molluscicidal and mosquitocidal activities of the essential oils of Thymus capitatus HOFF. ET LINK. And Marrubiumvulgare L. Rev. Inst. Med. Trop. Sao Paulo., 54(5): 281-286.

Saleh, M.M. and Glombitza, K.W. 1989. Volatile Oil of Marrubiumvulgareandits Anti-schistosomal Activity. Planta Med., 55:105-108.

Salehi, S., Golparvar, A.R. and Hadipanah, A. 2014. Effect of harvest time on yield and quality of Thymus vulgaris L. essential oil in Isfahan province, Iran. Agriculturae Conspectus Scientificus., 79(2): 115-118.

Weel, K.C.G., Venskutonis, P.R., Pukalskas, A., Gruzdiene, D. and Linssen, J.P.H. 1999. Antioxidant activity of horehound (Marrubiumvulgare) grown in Lithuania. Fett/Lipid., 101(10): 395-400.

Zawislak, G. 2012. Chemical composition of essential oils of MarrubiumvulgareL. and MarrubiumincanumDesr. grown in Poland.Chemija., 23(2): 136–140.