A novel three-component reactions of 4-hydroxycumarine for the synthesis of oxazine derivatives in water

الموضوعات : Iranian Journal of Organic Chemistry

Seyyed Jalal Shams Najafi ¹ ()
Maryam Ghazvini ² ()
Atefeh Navabi ³ ()

تاريخ الإرسال : 02 الأحد , ربيع الأول, 1445 تاريخ التأكيد : 02 الأحد , ربيع الأول, 1445 تاريخ الإصدار : 14 الثلاثاء , محرم, 1445

الکلمات المفتاحية: 1, Three-component reaction, isocyanide, 2-hydroxyacetophenone, 3-benzoxazine, Isoquinoline,

ملخص المقالة :

A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 2-naphthol in water in the presence of piperidine at 70oC is reported.