Synthesis of iminofurane derivatives using one pot multicomponent reaction: Dynamic NMR Study

الموضوعات : Iranian Journal of Organic Chemistry

Sayyed Jalal Shams-Najafi ¹ , Maryam Ghazvini ² , Faramarz Rostami-Charati ³

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تاريخ الإرسال : 08 الثلاثاء , شعبان, 1444 تاريخ التأكيد : 08 الثلاثاء , شعبان, 1444 تاريخ الإصدار : 10 الأربعاء , رجب, 1444

الکلمات المفتاحية: Dibenzoylacetylene, Ninhydrin, Alkyl(aryl) isocyanides, Dynamic NMR, Ammonium acetate,

ملخص المقالة :

In this research the reaction between alkyl(aryl) isocyanides, dibenzoylacetylene, ninhydrin and ammonium acetate leads to production of highly functionalized inminofuranes. A dynamic NMR effect is observed in the 1H NMR spectra of these compounds as a result of restricted rotation around the single bond linking the indole moiety and the furan system. The free-energy of activation (ΔG#) for this process is 75-83 kJ mol-1.