Green synthesis of isoquinoline derivatives using mlticomponent reaction of ninhydrin

الموضوعات : Iranian Journal of Organic Chemistry

Samanehsadat Sharifi ¹ , Narjes Haeizadeh ²

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تاريخ الإرسال : 08 الثلاثاء , شعبان, 1444 تاريخ التأكيد : 08 الثلاثاء , شعبان, 1444 تاريخ الإصدار : 10 الأربعاء , رجب, 1444

الکلمات المفتاحية: Ninhydrin, Spiro compounds, Acetylenedicarboxylates, N-Heterocycles,

ملخص المقالة :

In this work, The 1,3-dipolar intermediates generated by addition of isoquinoline to dialkyl acetylenedicaboxylates are trapped by ninhydrin to produce spiro compounds in excellent yields. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.