بررسی اثر کپسول گیاهی لیپکسان در کاهش تری گلیسرید، کلسترول وLDL در مدل حیوانی
محورهای موضوعی : زیست شناسی
1 - استادیار، گروه زیست‌شناسی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران
کلید واژه: کپسول لیپکسان, کلسترول, تری‌‌گلیسیرید, LDL, جم‌‌فیبروزیل, کپسول‌های گیاهی, موش.,
چکیده مقاله :
هدف: نقش گیاهان در کاهش چربی‌‌های خون و در نتیجه کاهش احتمال بروز بیماری‌‌های قلبی- عروقی شناخته شده است. در این راستا، هدف پژوهش حاضر بررسی اثر کپسول لیپکسان در کاهش تری گلیسرید، کلسترول وLDL در مدل حیوانی می‌‌باشد.
روش: در این پژوهش از 40 سر موش‌‌های صحرایی نر نژاد ویستار با وزن تقریبی 20±200 گرم استفاده شد. موش‌‌‌ها به صورت تصادفی به 5 گروه 8 تایی شامل گروه کنترل با رژیم غذایی و گروه شاهد با رژیم غذایی پرچرب (به مدت 21 روز)، گروه تیمار با کپسول لیپکسان با دوز 90، گروه تیمار با کپسول لیپکسان با دوز Min و گروه تیمار با کپسول جم فیبروزیل (به مدت 30 روز) تقسیم شدند. خون‌گیری نیز در پایان انجام شد. مقادیر کلسترول، تری‌‌گلیسیرید و LDL اندازه‌گیری گردید. از آنالیز واریانس یک‌‌طرفه جهت تحلیل داده‌ها استفاده شد.
یافته‌ها: غلظت‌های سرمی کلسترول، تری‌‌گلیسیرید و LDL در گروه‌‌های تحت تیمار با کپسول لیپکسان Min و 90 و گروه جم فیبروزیل به طور معنی‌‌داری نسبت به گروه کنترل با غذای استاندارد و گروه شاهد با غذای پرچرب کاهش یافته است.
نتیجه‌‌گیری: کپسول لیپکسان بر غلظت کلسترول، تری‌‌گلیسیرید و LDL در موش‌‌های هیپرلیپیدمیک موثر واقع شده است. می‌توان از کپسول لیپکسان در کاهش سطح چربی‌‌های خون، به عنوان یک روش درمانی یا پیشگیری موثر برای هیپرلیپیدمی استفاده نمود.
Purpose: The role of plants in reducing blood lipids and thus reducing the risk of cardiovascular diseases is known. In this regard, the aim of the current study is to investigate the effect of Lipexan capsules in reducing triglycerides, cholesterol and LDL in an animal model.
Materials and methods: In this research, 40 male Wistar rats with an approximate weight of 200±20 grams were used. Mice were randomly divided into 5 groups of 8, including the control group with diet and the control group with high-fat diet (for 21 days), the treatment group with lipexan capsules with a dose of 90, the treatment group with lipexan capsules with a dose of Min and the treatment group with Fibrozil jam capsules (for 30 days) were divided. Blood sampling was done at the end. Cholesterol, triglyceride and LDL values were measured. One-way analysis of variance was used to analyze the data.
Findings: The serum concentrations of cholesterol, triglyceride and LDL in the groups treated with Lipexan Min and 90 capsules and the Fibrozil Jam group were significantly reduced compared to the control group with standard food and the control group with high-fat food.
Conclusion: Lipexan capsule has an effect on the concentration of cholesterol, triglyceride and LDL in hyperlipidemic rats. Lipexan capsules can be used to reduce the level of blood lipids, as an effective treatment or prevention method for hyperlipidemia.
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