مروری بر تشکیل بیوفیلم و کوروم سنسینگ در باکتری سودوموناس آئروژینوزا

Subject Areas : Journal of Quality and Durability of Agricultural Products and Food Stuffs

Rezvaneh  behzadmehr ¹ (Associate Professor, Department of Radiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran)
Maryam  Beigomi ² (Assistant Professor of Nutritional Sciences & Food Technology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran)
saeide  saeidi ³ (M.S, Agricultural Biotechnology Institute, University of Zabol, Zabol, Iran)

Received: 2022-01-22 Accepted : 2022-02-15 Published : 2022-02-20

Keywords: کوروم سنسینگ, بیوفیلم, سودوموناس آئروژینوزا, عصاره گیاه,

Abstract :

چکیده:سودوموناس آئروژینوزایک پاتوژن فرصت طلب و عامل10الی15درصد از عفونت های بیمارستانی میباشـد.وجـود ژن هـایحدت یکی از مهمترین مکانیسم های تهاجمی سودوموناس آئروژینوزامیباشد و این موضوع از نظر پزشـکی از اهمیـت ویـژه ای برخـورداراست.بیان بسیاری از ژن های بیماریزای باکتری سودوموناس آئروژینوزابه وسیله یک سیستم ژنی بـه نـام سیسـتمQuorum Sensing(QS)کنترل و تنظیم میگردند. کروم سنسینگ سیستم ارتباطی سلول به سلول با استفاده از مولکولهـای کوچـکSMsدر ارگانیسـم های تک سلولی است.هدف از تحقیق بررسی تشکیل بیوفیلم در سیستم کروم سنسـینگ در سـویه هـایسـودوموناس آئروژینـوزامیباشد.مطالعه مروری حاضر با کمک مقالات نمایهشده درپایگاههای علمی فارسی Magiran و SID وپایگاههای علمی انگلیسی Scopus، Google scholar، Ebscohostو Science Directبدست آمد.ژنهای سیستم QSفراوانی بالایی در بین سویه های سودوموناس آئروژینوزاجداشده از منابع انسانی دارند.همچنین این باکتری بعنوان یک باکتری عفونت زابا مقاومت آنتی بیوتیکی بالا میباشد.نتایج مطالعه نشان داد که گیاهان دارویی در رقت های مختلف مهار کننده کوروم سنسینگ و بیوفیلم در باکتری ها می باشند.

References:

1- Kalia V C. Quorum sensing inhibitors: an overview. Biotechnology advances. 2013;31(2):224-245.

2- Moradali MF, Ghods S, Rehm B H. Pseudomonas aeruginosa lifestyle: a par-adigm for adaptation, survival, and per-sistence. Frontiers in cellular and infection microbiology. 2017;7:39.

3- Klockgether J, Cramer N, Wiehlmann L, Davenport CF, Tümmler B. Pseudomonas aeruginosa genomic structure and divers-ity. Frontiers in microbiology. 2011;2:150.

4- Anderl JN, Franklin M J, Stewart P S. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicro-bial agents and chemotherapy. 2000;44(7): 1818-1824.

5- Jiménez-Gómez P, Pozuelo de Felipe M, Llinares Pinell F, García de los Ríos J. Quorum-sensing in Pseudomonas aerugin-osa and Salmonella: Active natural com-pounds as antagonists. Communicating Cu-rrent Research and Educational Topics and Trends in Applied Microbiology. 2007;1: 41-51.

6- Kalia VC, Wood TK, Kumar P. Evo-lution of resistance to quorum-sensing inhibitors. Microbial ecology. 2004;68(1): 13-23.

7- Pesci EC, Pearson JP, Seed PC, Iglewski B H. Regulation of las and rhl quorum sensing in Pseudomonas aerugino-sa. Journal of bacteriology. 1997;179(10): 312-73132.

8- Jacobsen S, Stickler D, Mobley H, Shirtliff M. Complicated catheter-associat-ed urinary tract infections due to Esch-erichia coli and Proteus mirabilis. Clinical microbiology reviews. 2008;21(1):26-59.

9- Cady NC, McKean KA, Behnke J, Kubec R, Mosier AP, Kasper SH, Musah RA. Inhibition of biofilm formation, qu-orum sensing and infection in Pseu-domonas aeruginosa by natural products-inspired organosulfur compounds. PloS one. 2012;7(6):e38492.

10- McDougald D, Rice SA, Kjelleberg S. Bacterial quorum sensing and interference by naturally occurring biomimics. Analy-tical and bioanalytical chemistry. 2007; 387(2):445-453.

11- Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Givskov M. Effects of antibiotics on qu-orum sensing in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 2008;52(10):3648-3663.

12- Bjarnsholt T, Jensen PØ, Jakobsen TH, Phipps R, Nielsen AK, Rybtke MT, Ciofu O. Quorum sensing and virulence of Pseudomonas aeruginosa during lung infe-ction of cystic fibrosis patients. PloS one. 2010;5(4).

13- Rasmussen TB, Bjarnsholt T, Skinde-rsoe ME, Hentzer M, Kristoffersen P, Köte M, Givskov M. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. Journal of bacteriology. 2005;187(5):1799-1814.

14- Susilowati H, Murakami K, Yumot H, Amoh T, Hirao K, Hirota K, Miyake Y. Royal jelly inhibits Pseudomonas aerug-inosa adherence and reduces excessive inflammatory responses in human epith-elial cells. BioMed research international, 2017.

15- Moreau-Marquis S, O'Toole GA, Sta-nton BA. Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aer-uginosa biofilms on cystic fibrosis cells. American journal of respiratory cell and molecular biology. 2009;41(3):305-313.

16- Papareddy P, Kasetty G, Kalle M, Bhongir RK, Mörgelin M, Schmidtchen A, Malmsten M. NLF20: an antimicrobial peptide with therapeutic potential against invasive Pseudomonas aeruginosa infec-tion. Journal of antimicrobial chemothe-rapy. 2016;71(1):170-180.

17- Istanbullu O, Babauta J, Duc Nguyen H, Beyenal H. Electrochemical biofilm control: mechanism of action. Biofouling. 2012;28(8):769-778.

18- Sultana ST, Call DR, Beyenal H. Eradication of Pseudomonas aeruginosa biofilms and persister cells using an ele-ctrochemical scaffold and enhanced ant-ibiotic susceptibility. NPJ biofilms and microbiomes. 2016;2(1):1-8.

19- Hay ID, Gatland K, Campisano A, Jordens JZ, Rehm BH. Impact of alginate overproduction on attachment and biofilm architecture of a supermucoid Pseudom-onas aeruginosa strain. Applied and envir-onmental microbiology. 2009;75(18):6022-6025.

20- Ma L, Conover M, Lu H, Parsek MR, Bayles K,Wozniak DJ. Assembly and development of the Pseudomonas aerug-inosa biofilm matrix. PLoS Pathogens. 2009;5(3):e1000354.

21- Bjarnsholt T, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Eberl L. Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Micr-obiology. 2005;151(12):3873-3880.

22- Möker N, Dean CR, Tao J. Pseud-omonas aeruginosa increases formation of multidrug-tolerant persister cells in resp-onse to quorum-sensing signaling mole-cules. Journal of bacteriology. 2010; 192(7):1946-1955.

23- Bala A, Kumar R, Harjai K. Inhibition of quorum sensing in Pseudomonas aer-uginosa by azithromycin and its effectiv-eness in urinary tract infections. Journal of medical microbiology. 2011;60(3):300-306.

24- Ghafoor A, Hay ID, Rehm BH. Role of exopolysaccharides in Pseudomonas aeru-ginosa biofilm formation and architecture. Applied and environmental microbiology. 2011;77(15):5238-5246

25- Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, Beer K, Wang Y. Active starvation responses mediate antib-iotic tolerance in biofilms and nutrient-limited bacteria. Science. 2011;334(6058): 982-986.

26- Jacobsen S, Stickler D, Mobley H, Shirtliff M. Complicated catheter-asso-ciated urinary tract infections due to Escherichia coli and Proteus mirabilis. Clinical microbiology reviews. 2008;21(1): 26-59.

27- Saviuc C, Cotar AI, Holban A ,Banu O, Grumezescu A, Chifiriuc M. Phenot-ypic and molecular evaluation of Pseud-omonas aeruginosa and Staphylococcus aureus virulence patterns in the presence of some essential oils and their major compounds. Letters in Applied NanoBio-Science. 2013;2(1):91-96.

28- O’Loughlin CT, Miller LC, Siryaporn A, Drescher K, Semmelhack MF, Bassler BL. A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proceedings of the Na-tional Academy of Sciences. 2013;110(44): 17981-17986.

29- Ponsoni K, Raddi MSG, de Almeida DV, Almeida AE, Alécio AC. Effects of liver S9 enzymes on somalargine and solasodine cytotoxicity and mass spectr-ometric fragmentation. European Food Research and Technology. 2013;237(2): 179-184.

30- Musafer HK, Kuchma SL, Naimie AA, Schwartzman JD, AL-Mathkhury HJF, O’Toole, GA. Investigating the link be-tween imipenem resistance and biofilm formation by Pseudomonas aeruginosa. Microbial ecology. 2014;68(1):111-120.

31- Dosler S, Karaaslan E. Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides. Peptides. 2014;62:32-37.

32- Kalia VC, Wood TK, Kumar P. Evolution of resistance to quorum-sensing inhibitors. Microbial ecology. 2014;68(1): 13-23.

33- Rahman MRT, Lou Z, Yu F, Wang P, Wang H. Anti-quorum sensing and anti-biofilm activity of Amomum tsaoko (Am-ommum tsao-ko Crevost et Lemarie) on foodborne pathogens. Saudi journal of biological sciences. 2017;24(2):324-330.

34- Boulanger S, Mitchell G, Bouarab K, Marsault É, Cantin A, Frost EH, Malouin F. Bactericidal effect of tomatidine-tob-ramycin combination against methicillin-resistant staphylococcus aureus and Pseudomonas aeruginosa is enhanced by interspecific small-molecule interactions. Antimicrobial agents and chemotherapy. 2015;59(12):7458-7464.

35- Sepahi E, Tarighi S, Ahmadi FS, Bagheri A. Inhibition of quorum sensing in Pseudomonas aeruginosa by two herbal essential oils from Apiaceae family. Jo-urnal of microbiology. 2015;53(2):176-180.

36- Berrazeg M, Jeannot K, Enguéné VYN, Broutin I, Loeffert S, Fournier D, Plésiat P. Mutations in β-lactamase AmpC increase resistance of Pseudomonas aeru-ginosa isolates to antipseudomonal cepha-losporins. Antimicrobial agents and chem-otherapy. 2015;59(10):6248-6255.

37- Kumar L, Chhibber S, Kumar R, Ku-mar M, Harjai K. Zingerone silences qu-orum sensing and attenuates virulence of Pseudomonas aeruginosa. Fitoterapia. 2015;102:84-95.

38- Bouffartigues E, Moscoso JA, Du-chesne R, Rosay T, Fito-Boncompte L, Gicquel G, Brenner-Weiss G. The absence of the Pseudomonas aeruginosa OprF pro-tein leads to increased biofilm formation through variation in c-di-GMP level. Fro-ntiers in microbiology. 2015;6:630.

39- De La Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, He-rnández D, Brackman G, Hancock RE. D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeru-ginosa infections. Chemistry & biolo-gy.2015;22(2):196-205.

40- Bahar AA, Liu Z, Garafalo M, Kallenbach N, Ren D. Controlling persister and biofilm cells of Gram-negative bac-teria with a new 1, 3, 5-triazine derivative. Pharmaceuticals. 2015;8(4):696-710.

41- Berditsch M, Jäger T, Strempel N, Schwartz T, Overhage J, Ulrich AS. Syn-ergistic effect of membrane-active peptides polymyxin B and gramicidin S on mu-ltidrug-resistant strains and biofilms of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 2015;59(9): 5288-5296.

42- Lebeaux D, Leflon-Guibout V, Ghigo JM, Beloin C. In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of bio-film-forming clinical strains isolated from catheter-related infections. Journal of antimicrobial chemotherapy. 2015;70(6): 1704-1712.

43- Rudilla H, Fusté E, Cajal Y, Rabanal F, Vinuesa T, Viñas M. Synergistic anti-pseudomonal effects of synthetic peptide AMP38 and carbapenems. Molecules. 2016;21(9):1223.

44- Field D, Seisling N, Cotter PD, Ross RP, Hill C. Synergistic nisin-polymyxin combinations for the control of Pseu-domonas biofilm formation. Frontiers in microbiology. 2016;7:1713.

45- El-Shaer S, Shaaban M, Barwa R, Hassan R. Control of quorum sensing and virulence factors of Pseudomonas aeru-ginosa using phenylalanine arginyl β-naphthylamide. Journal of medical micro-biology. 2016;65(10):1194-1204.

46- Gökalsın B, Sesal NC. Lichen secondary metabolite evernic acid as pot-ential quorum sensing inhibitor against Pseudomonas aeruginosa. World Journal of Microbiology and Biotechnology. 2016; 32(9):150.  

47- Datta S, Jana D, Maity TR, Samanta A, Banerjee R. Piper betle leaf extract affects the quorum sensing and hence virulence of Pseudomonas aeruginosa PAO1. 3 Bio-tech. 2016;6(1):18.

48- Abd El-Aziz NK, Abd El-Hamid MI, El-Naenaeey EY. A complex hierarchical quorum-sensing circuitry modulates phena-zine gene expression in Pseudomonas aeruginosa. The Journal of Infection in Developing Countries. 2017;11(12):919-925.

49- Hossain MA, Lee SJ, Park NH, Mechesso AF, Birhanu BT, Kang J, Park SC. Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways. Scientific re-ports. 2017;7(1):1-16.

50- Grassi L, Maisetta G, Esin S, Batoni G. Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms. Frontiers in microbio-logy. 2017;8:2409.

51- Høyland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL. Quorum sensing controls the Pseudomonas aerug-inosa CRISPR-Cas adaptive immune sys-tem. Proceedings of the National Academy of Sciences. 2017;114(1):131-135.

52- Paczkowski JE, Mukherjee S, McCr-eady AR, Cong JP, Aquino CJ, Kim H, Bassler BL. Flavonoids suppress Pseudom-onas aeruginosa virulence through allo-steric inhibition of quorum-sensing rece-ptors. Journal of Biological Chemistry. 2017;292(10):4064-4076.

53- Fong SA, Drilling A, Morales S, Cornet ME, Woodworth BA, Fokkens WJ, Wormald PJ. Activity of bacteriophages in removing biofilms of Pseudomonas aerug-inosa isolates from chronic rhinosinusitis patients. Frontiers in cellular and infection microbiology. 2017;7:418.

54- Shah MD, Kharkar PS, Sahu NU, Peerzada Z, Desai KB. Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in Pseudomonas aeruginosa via LasIR/RhlIR circuitry. RSC Advances. 2019;9(69): 40228-40239.

55- Ahmed SA, Rudden M, Smyth TJ, Dooley JS, Marchant R, Banat IM. Natural quorum sensing inhibitors effectively dow-nregulate gene expression of Pseudomonas aeruginosa virulence factors. Applied mic-robiology and biotechnology. 2019;103(8): 3521-3535.

56- Malgaonkar A, Nair M. Quorum sens-ing in Pseudomonas aeruginosa mediated by RhlR is regulated by a small RNA PhrD. Scientific reports. 2019;9(1):1-11.

57- Ahmed AA, Salih FA. Low concen-trations of local honey modulate Exotoxin A expression, and quorum sensing related virulence in drug-resistant Pseudomonas aeruginosa recovered from infected burn wounds. Iranian Journal of Basic Medical Sciences. 2019;22(5):568.

58- Kamali E, Jamali A, Ardebili A, Ezadi F, Mohebbi A. Evaluation of antimicrobial resistance, biofilm forming potential, and the presence of biofilm-related genes am-ong clinical isolates of Pseudomonas aeruginosa. BMC Research Notes. 2020; 13(1):27.