Application of Box-Behnken Method for Optimization and Modeling of 1,5 –Benzodiazepine Production Reaction by CuFe2O4/Clinoptilolite Nanocatalyst
Subject Areas : Applied Mathematics ModelingNazanin Gholamrezaeenya 1 , Kazem Mahanpoor 2 , Keivan Ghodrati 3 , Azam Marjani 4 , Masoomeh Abdoli-Senejani 5
1 - Department of Chemistry, Arak Branch, Islamic Azad University, Arak, I.R. IRAN
2 - Department of Chemistry, Faculty of science, Arak Branch, Islamic Azad University, Arak, Iran
3 - Department of Chemistry, Kermanshah Branch, Islamic Azad University, Kermanshah,. I.R. IRAN
4 - Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran
5 - Department of chemistry, Islamic azad university, Arak branch
Keywords: Box-Behnken, Optimization, 1, 5-Benzodiazepine, CuFe2O4/Clinoptilolite ,
Abstract :
In this study, the Box-Behnken design (BBD) was used in the response surface method (RSM) to investigate the modeling and optimization parameters in the synthesis of a 1,5-Benzodiazepine. This method was used to optimize the influencing factors in the synthesis process of this material, including the amount of nanocatalyst, temperature, and reaction time. The obtained mathematical model was analyzed by variance analysis. To determine the optimal conditions, graphs of graphic counters and response levels were used. The results showed that the amount of nanocatalyst has the greatest effect on the synthesis reaction of 1.5 Benzodiazepines. The maximum efficiency for the synthesis of the product was determined at a temperature of 283 K, the amount of CuFe2O4/Clinoptilolite = 6 g/lr and time = 60 minutes.
[1] Niasar HS, Li H, Das S, Kasanneni TV, Ray MB, Xu CC. Preparation of activated petroleum coke for removal of naphthenic acids model compounds: Box-Behnken design optimization of KOH activation process. Journal of environmental management. 2018 Apr 1; 211: 63-72.
[2] Thirugnanasambandham K, Sivakumar V, Maran JP. Efficiency of electrocoagulation method to treat chicken processing industry wastewater—modeling and optimization. Journal of the Taiwan Institute of Chemical Engineers. 2014 Sep 1;45(5):2427-35.
[3] Karichappan T, Venkatachalam S, Jeganathan PM, Sengodan K. Treatment of rice mill wastewater using continuous electrocoagulation technique: optimization and modelling. 대한화학회지. 2013 Dec;57(6):761-8.
[4] Zhang H, Ran X, Wu X, Zhang D. Evaluation of electro-oxidation of biologically treated landfill leachate using response surface methodology. Journal of hazardous materials. 2011 Apr 15;188(1-3):261-8.
[5] Kabuk HA, İlhan F, Avsar Y, Kurt U, Apaydin O, Gonullu MT. Investigation of leachate treatment with electrocoagulation and optimization by response surface methodology. CLEAN–Soil, Air, Water. 2014 May;42(5):571-7.
[6] Rosid SJ, Bakar WA, Ali R. Characterization and modelling optimization on methanation activity using Box-Behnken design through cerium doped catalysts. Journal of cleaner production. 2018 Jan 1;170: 278-87.
[7] Mohadesi M, Shokri A. Evaluation of Fenton and photo-Fenton processes for the removal of p-chloronitrobenzene in aqueous environment using Box-Behnken design method. Desalination and Water treatment. 2017;81: 199-208.
[8] Moradi M, Daryan JT, Mohamadalizadeh A. Response surface modeling of H2S conversion by catalytic oxidation reaction over catalysts based on SiC nanoparticles using Box− Behnken experimental design. Fuel processing technology. 2013 May 1;109: 163-71.
[9] Nam SN, Cho H, Han J, Her N, Yoon J. Photocatalytic degradation of acesulfame K: optimization using the Box–Behnken design (BBD). Process Safety and Environmental Protection. 2018 Jan 1; 113: 10-21.
[10] Shahri FB, Niazi A. Synthesis of modified maghemite nanoparticles and its application for removal of acridine orange from aqueous solutions by using Box-Behnken design. Journal of Magnetism and Magnetic Materials. 2015 Dec 15; 396: 318-26.
[11] Mokhtar WN, Bakar WA, Ali R, Kadir AA. Deep desulfurization of model diesel by extraction with N, N-dimethylformamide: Optimization by Box–Behnken design. Journal of the Taiwan Institute of chemical Engineers. 2014 Jul 1;45(4):1542-8.
[12] Shen C, Chang Y, Fang L, Min M, Xiong CH. Selective removal of copper with polystyrene–1, 3-diaminourea chelating resin: synthesis and adsorption studies. New Journal of Chemistry. 2016;40(4):3588-96.
[13] Saghi M, Mahanpoor K. Photocatalytic degradation of tetracycline aqueous solutions by nanospherical α-Fe 2 O 3 supported on 12-tungstosilicic acid as catalyst: Using full factorial experimental design. International Journal of Industrial Chemistry. 2017 Sep; 8:297-313.
[14] Li Y, Zhou S, Fang L, Li J, Zheng X, Jiang J, Xiong C. Adsorptive removal of Ni (II) from aqueous solution on 110-H resin: optimization through response surface methodology. Desalination and Water Treatment. 2016 May 14;57(23):10710-22.
[15] Ravanfar R, Tamaddon AM, Niakousari M, Moein MR. Preservation of anthocyanins in solid lipid nanoparticles: Optimization of a microemulsion dilution method using the Placket–Burman and Box–Behnken designs. Food chemistry. 2016 May 15; 199: 573-80.