بررسی خواص سایشی و رادیواپسیته ایمپلنت پلی اتر اتر کتون پوشش دهی شده با اکسید استرانسیم برای درمان پارگی رباط صلیبی قدامی
محورهای موضوعی : بیومواد
1 - مدیرگروه کارشناسی ارشد مهندسی پزشکی دانشگاه ازاد اسلامی واحد یزد
کلید واژه: پوشش دهی, رادیواپسیته, لیگامان صلیبی قدامی, پلی اتر اتر کتون, اکسید استرانسیم,
چکیده مقاله :
یکی از شایع‌ترین مراجعات درمانگاهی ارتوپدی، تروماهای مستقیم و غیرمستقیم به زانو است که سبب پارگی لیگامان صلیبی قدامی می‌شود. کاربرد ایمپلنت از جنس تیتانیوم یکی از راه های بازسازی لیگامان صلیبی است که دارای محدودیت هایی از جمله رهایش یون ها ی سمی مانند وانادیوم و آلومینیوم از آلیاژ تیتانیوم می باشد. بنابراین در این مطالعه، ایمپلنت از جنس پلیمر پلی اتر اتر کتون (PEEK) با دستگاه CNC ساخته شد و سطح ایمپلنت با اکسید استرانسیم(SrO) برای ساخت یک ایمپلنت پلیمری رادیواپک پوشش دهی شد. پوشش دهی سطح ایمپلنت پلیمری با روش پوشش دهی چرخشی -غوطه وری در دو شرایط متفاوت دمایی در دمای محیط و دمای ℃ ۷۰ انجام شد. سپس خواص سایشی و سطحی ایمپلنت مورد ارزیابی قرار گرفت. مورفولوژی سطح، ریزساختار و توزیع عناصر روی سطح ایمپلنت به ترتیب توسطEDS، XRD، SEM و آنالیز MAP ارزیابی گردید. مشاهده تصاویر رادیوگرافی واضح از ایمپلنت PEEK با پوششSrO دلیلی بر رادیواپک شدن ایمپلنت پلیمری بود. میزان کاهش وزن برای ایمپلنت PEEK و ایمپلنت PEEK با پوشش SrO در سیکل ۱۵۰۰ مرتبه به ترتیب ۰۰۰۶/۰ گرم و ۰۰۰۴/۰ گرم محاسبه گردید.مقاومت سایشی مناسب در دو سیکل ۵۰۰ و ۱۵۰۰ مرتبه برای منافذ و سطح ایمپلنت PEEK با پوشش SrO مشاهده شد. نتایج آزمون کشت سلول و رنگ آمیزیlive/dead،د۹۸٪ رشد و تکثیر سلولها را بر روی سطح ایمپلنت PEEK با پوشش SrO نشان داد. بنابراین یافته های این تحقیق نشان داد که ایمپلنت PEEK با پوشش SrO می تواند به عنوان یک جایگزین مناسب برای ایمپلنت اندوباتون به کار رود.
One of the most common orthopedic clinic referrals is direct and indirect traumas to the knee that lead to anterior cruciate ligament rupture. The use of titanium implants is one of the ways to treat and reconstruct the cruciate ligament, which has limitations, including the release of toxic ions such as aluminum and vanadium from the titanium alloy. In the present study, the polyether ether ketone (PEEK) implant was fabricated using a CNC machine. Then the surface of the implant was coated with strontium oxide (SrO) by dip spin coating method in two temperature conditions, including ambient temperature and 70 ℃ to produce a radiopaque polymer. After coating, the wear and surface properties of the implant were evaluated. The surface morphology, microstructure, and distribution of elements on the implant surface were evaluated by scanning electron microscope (SEM), X-Ray Diffraction (XRD), X-ray energy diffraction spectroscopy(EDS), and MAP analysis, respectively. The radiographic images indicated the good radiopacity level of the SrO-coated PEEK implant. The amount of weight loss for the PEEK implant and the SrO-coated PEEK implant was 0.0006 g and 0.0004 g in 1500 cycles, respectively. Good wear resistance was observed in two cycles of 500 and 1500 for the pores and surface of the SrO-coated PEEK implant. The results of the cell culture and live/dead staining showed 98% growth and proliferation of cells on the SrO-coated PEEK implant. Therefore, the findings of this study demonstrated that the SrO-coated PEEK implant can be used as a suitable alternative for the Endobutton.
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7- پی‌نوشت
[ ] Anterior Cruciate Ligament
[2] Biocompatibility
[3] In vivo
[4] In vitro
[5] Inert
[6] Dip Spin Coating
[7] Dulbecco's Modified Eagle Medium
[8] Fetal Bovine Serum
[9] KATI
[10] Computer Numerical Control
[11] Energy-Dispersive X-Ray Spectroscopy
[12] X-Ray Diffraction
[13] Vision Measuring Machine
[14] Methyl Thiazol Terazolium
[15] Dimethyl Sulfoxideimet
[16] Phosphate-Buffered Saline