مطالعه میکرونیدلینگ در درمان آلوپشیای ایکس در سگ های پامرانین
محورهای موضوعی : بیماریهای دامهای کوچک
درسا دیناشی
1
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سیدمرتضی رزاقی منش
2
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سیده ام البنین قاسمیان
3
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فاطمه همایون
4
1 - دانش آموخته دکتری عمومی دامپزشکی، گروه دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران
2 - گروه علوم درمانگاهی دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران
3 - گروه کلینکال پاتولوژی دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران
4 - دانشجوی دکتری عمومی دامپزشکی، گروه دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران
کلید واژه: پامرانین, آلوپشیای ایکس, میکرونیدلینگ,
چکیده مقاله :
آلوپسیX یک بیماری پوستی شایع در پامرانین است که با آلوپسی متقارن و غیر التهابی مشخص می‌شود. درمان های قبلی با داروهای مختلف موضعی و سیستمیک موفقیت متغیری داشته اند.این مطالعه با هدف اثربخشی میکرونیدلینگ در القای رشد طولانی مدت مو در پامرانین مبتلا به آلوپسیX انجام شد. 40 پامرانین عقیم شده با آلوپسیX تایید شده در دو گروه کنترل و درمان وارد مطالعه شدند. سگ ها به درمان های قبلی با دسلورلین، ملاتونین و ماینوکسیدیل موضعی پاسخ نداده بودند. تحت بیهوشی، پوست با دستگاه میکرونیدلینگ سوراخ شد. سگ ها به مدت 6ماه پیگیری شدند. پنج هفته پس از میکرونیدلینگ، رشد مجدد مو شروع شد که با کاهش هیپرپیگمانتاسیون همراه بود. در هفته 12، 90 درصد بهبودی در پوشش پوشش در نواحی که قبلا آلوپسی داشتند، مشاهده شد. در 6 ماهگی، کوت بدون عوارض جانبی ثابت ماند. این اولین گزارشی است که نشان می‌دهد میکرونیدلینگ می‌تواند باعث رشد طولانی‌مدت مو در سگ‌های مبتلا به آلوپسیX شود. نتایج نشان می‌دهد که میکرونیدلینگ بازسازی فولیکول مو را تحریک می‌کند، به طور بالقوه با فعال کردن سلول‌های بنیادی، افزایش جریان خون و تعدیل مسیرهای التهابی. مطالعات طولانی مدت در تعداد بیشتری از سگ ها برای تایید این یافته های اولیه و تعیین اینکه آیا رشد مجدد مو دائمی است یا خیر، مورد نیاز است.این مطالعه نشان می‌دهد که میکرونیدلینگ یک گزینه درمانی جدید امیدوارکننده برای آلوپسیX در پامرانین است. میکرونیدلینگ ممکن است با تحریک رشد مجدد مو و کاهش تاثیر زیبایی این شرایط چالش برانگیز، کیفیت زندگی سگ های مبتلا را بهبود بخشد.
Alopecia X is a common skin condition in Pomeranians characterized by symmetrical, non-inflammatory alopecia. Previous treatments with various topical and systemic drugs have had varying degrees of success. This study aimed to investigate the efficacy of microneedling in inducing long-term hair regrowth in Pomeranians with alopecia X. 40 neutered Pomeranians with confirmed alopecia X were enrolled in control and treatment groups. The dogs had not responded to previous treatments with deslorelin, melatonin, and topical minoxidil. Under anesthesia, the skin was punctured with a microneedling device. The dogs were followed for 6 months. Five weeks after microneedling, hair regrowth started, accompanied by a reduction in hyperpigmentation. At 12 weeks, a 90% improvement in coat coverage in previously alopecic areas was observed. At 6 months, the coat remained stable without adverse effects. This is the first report showing that microneedling can induce long-term hair regrowth in dogs with alopecia X. The results suggest that microneedling stimulates hair follicle regeneration, potentially by activating stem cells, increasing blood flow, and modulating inflammatory pathways. ong-term studies in a larger number of dogs are needed to confirm these initial findings and determine whether the hair regrowth is permanent. However, this study indicates that microneedling represents a promising new treatment option for alopecia X in Pomeranians. Microneedling may improve the quality of life of affected dogs by stimulating hair regrowth and reducing the cosmetic impact of this challenging condition.
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