مطالعه چهره‌های بالینی و هماتولوژیک ازدیاد حساسیت به نیش حشرات در اسبان استان خوزستان
محورهای موضوعی :
آسیب شناسی درمانگاهی دامپزشکی
بهاره سلیمانی
1
,
علی رضا قدردان مشهدی
2
,
محمد رحیم حاجی حاجیکلایی
3
,
محمد راضی جلالی
4
,
مسعود قربانپور
5
,
رحیم چینی پرداز
6
1 - دانش‌آموخته دکترای تخصصی بیماری‌های داخلی دام‌های بزرگ، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
2 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
3 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
4 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
5 - استاد گروه پاتوبیولوژی، دانشکده دامپزشکی، دانشگاه شهید چمران اهواز، اهواز، ایران.
6 - استاد گروه آمار، دانشکده علوم ریاضی و کامپیوتر، دانشگاه شهید چمران اهواز، اهواز، ایران.
تاریخ دریافت : 1400/10/28
تاریخ پذیرش : 1400/11/20
تاریخ انتشار : 1400/11/01
کلید واژه:
اسب,
ازدیاد حساسیت به نیش حشرات,
چهره بالینی,
چهره هماتولوژیک,
چکیده مقاله :
ازدیاد حساسیت به نیش حشرات یک بیماری پوستی آلرژیک راجعه و مزمن اسب است که به فراوانی در اسبان نگه داری شده در استان خوزستان مورد ظن قرار می گیرد. هدف از تحقیق حاضر، ارزیابی چهره های بالینی و هماتولوژیک ازدیاد حساسیت به نیش حشرات در اسبان این استان بوده است. این مطالعه، روی 255 رأس اسب نژاد عرب، در 6 شهرستان استان خوزستان (شامل شوشتر، باوی، اهواز، سوسنگرد، آبادان و رامهرمز) به انجام رسید. اسبان تحت بررسی، از نظر حضور و محل ضایعات پوستی معاینه می شدند. سپس، نمونه خون تعدادی از دام ها (32 رأس اسب سالم و 61 رأس اسب واجد ضایعه)، اخذ می گردید. نمونه های خون، از نظر سیمای هماتولوژیک ارزیابی می شدند. داده های به دست آمده با استفاده از ارزیابی توصیفی، آزمون آنالیز واریانس و مقایسه نسبت ها مورد تجزیه و تحلیل قرار گرفتند. نتایج نشان داد که اصلی ترین ضایعه قابل مشاهده در دام های مبتلا، آلوپسی (با فراوانی 1/93 درصد) و کم ترین آن اسکار (4/1 درصد) و همچنین بیش ترین محل بروز ضایعات، ناحیه سر و گردن (6/85 درصد) بوده است. همچنین در عمده اسبان مبتلا (5/37 درصد) نشانه های پوستی در تمامی قسمت های بدن (شامل سر و گردن، تنه و اندام های حرکتی) وجود داشته، توزیع ضایعات در نواحی مختلف بدن مشابه بوده است. در ارزیابی آماری نتایج هماتولوژیک، تنها اختلاف بین تعداد بازوفیل ها و مقادیر میانگین حجم گلبول های قرمز و میانگین غلظت هموگلوبین دام های سالم و بیمار معنی دار تشخیص داده شد(05/0p<). این مطالعه نشان داد که در دام های مبتلا به ازدیاد حساسیت به نیش حشرات، ضایعات پوستی از تنوع، فراوانی و توزیع قابل توجهی برخوردار بوده است.
چکیده انگلیسی:
This study aimed to evaluate the clinical and hematological features of Insect bite hypersensitivity (IBH) among horses in Khuzestan. The study was performed on 257 Arabian horses kept in 6 cities of this province (including Shushtar, Bavi, Ahvaz, Susangard, Abadan, and Ramhormoz). The horses were examined for the presence or absence and location of skin lesions, along with the individual animal information, which was recorded. Blood sampling was done in some animals (32 healthy horses and 61 affected horses), the blood samples were evaluated for hematologic appearance. The collected data were analyzed using SPSS software. Results showed that the main lesions visible in infected animals were hair loss (with a frequency of 93.1%) and the lowest was scarring (1.4%). The location of skin lesions was reported to be mainly in the head and neck area (85.6%). Also, in the majority of the infected horses (37.5%), there were skin lesions in all parts of the body (including head and neck, trunk, and limbs). The distribution of the skin lesions observed in different areas of the body of the studied animals was almost similar, and so all three sites of alopecia demonstrated the highest frequency and the lowest frequency of scars. The analysis of hematological findings indicated that only the difference between the number of basophils and MCV and MCH values of healthy and IBH affected animals was found to be significant(P <0.05). The results of this study showed that the affected animals were marked by skin lesions diversity, frequency and distribution
منابع و مأخذ:
Althaus, H., Muller, N., Busato, A., Mellor, P., Torsteinsdottir, S.and Marti, E. (2004). Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera). Veterinary Immunology and Immunopathology, 99(1-2): 99-111.
Anderson, G.S., Belton, P. and Kleider, N. (1988). The hypersensitivity of horses to Culicoides bites in British Columbia. The Canadian Veterinary Journal, 29(9): 718.
Anderson, G., Belton, P. and Kleider, N. (1991). Culicoides obsoletus (Diptera: Ceratopogonidae) as a causal agent of Culicoides hypersensitivity (sweet itch) in British Columbia. Journal of Medical Entomology, 28(5): 685-693.
Baker, K. and Collins, E. (1984). A disease resembling sweet itch in Hong Kong. Equine Veterinary Journal, 16(5): 467-468.
Baker, K. and Quinn, P. (1978). A report on clinical aspects and histopathology of sweet itch. Equine Veterinary Journal, 10(4): 243-248.
Brostrom, H., Larsson, A. and Troedsson, M. (1987). Allergic dermatitis (sweet itch) of Icelandic horses in Sweden: an epidemiological study. Equine Veterinary Journal, 19(3): 229-236.
Constable, P.D., Hinchcliff, K.W., Done, S.H. and Grunberg, W. (2017). Veterinary Medicine, 11th ed., Missouri, Elsevier, pp: 1552, 1559-1560.
Fadok, V.A. and Greiner, E. (1990). Equine insect hypersensitivity: skin test and biopsy results correlated with clinical data. Equine Veterinary Journal, 22(4): 236-240.
Gerhardt, R.R. (1986). Culicoides spp. attracted to ruminants in the Great Smoky Mountains National Park, Tennessee. Journal of Agricultural Entomology, 3(2): 192-197.
Gould, H.J. and Sutton, B.J. (2008). IgE in allergy and asthma today. Nature Reviews Immunology, 8(3): 205-217.
Halldórdsóttir, S. and Larsen, H. (1991). An epidemiological study of summer eczema in Icelandic horses in Norway. Equine Veterinary Journal, 23(4): 296-299.
Henry, A. and Bory, L. (1937). Dermatose estivale recidivante du cheval. Pathologie et therapeutique. Recueil de Medecine Veterinaire, 113: 65-78. Quoted by: Brostrom, H., Larsson, Å and Troedsson, M. (1987). Allergic dermatitis (sweet itch) of Icelandic horses in Sweden: an epidemiological study. Equine Veterinary Journal, 19(3): 229-236.
Knottenbelt, D.C. (2009). Pascoes: Principles and Practice of Equine Dermatology, 2th ed., United Kingdom, Elsevier, pp: 284-286.
Kleider, N. and Lees, M. (1984). Culicoides hypersensitivity in the horse: 15 cases in southwestern British Columbia. The Canadian Veterinary Journal, 25(1): 26-32.
Kolm‐Stark, G. and Wagner, R. (2002). Intradermal skin testing in Icelandic horses in Austria. Equine Veterinary Journal, 34(4): 405-410.
Kurotaki, T., Narayama, K., Oyamada, T., Yoshikawa, H. and Yoshikawa, T. (1994). Immunopathological study on equine insect hypersensitivity (“kasen”) in Japan. Journal of Comparative Pathology, 110(2): 145-152.
Lange, S., Hamann, H., Deegen, E., Ohnesorge, B. and Distl, O. (2005). Investigation of the prevalence of summer eczema in Icelandic horses in northern Germany. Berliner und Munchener Tierarztliche Wochenschrift, 118(11-12): 481-489.
Langner, K.F., Darpel, K.E., Drolet, B.S., Fischer, A., Hampel, S., Heselhaus, J.E., et al. (2008). Comparison of cellular and humoral immunoassays for the assessment of summer eczema in horses. Veterinary Immunology and Immunopathology, 122(1-2): 126-137.
Lloyd, D.H., Littlewood, J.D., Craig, J.M. and Thomset, L.R. (2003). Practical Equine Dermatology. 2th ed., Denmark, Blackwell, pp: 18-20.
Littlewood, J.D. and Heidmann, P. (2006). The skin. In: Higgins. In: The Equine Manual. D.J. and Snyder, J.R. editors. 2nd ed., China, Elsevier, pp: 369-372.
Marsella, R. (2013). Equine allergy therapy: update on the treatment of environmental, insect bite hypersensitivity, and food allergies. Veterinary Clinics: Equine Practice, 29(3): 551-557.
Marsella, R. (2015). Ventral dermatitis. In: Robinsons Current Therapy in Equine medicine. Sprayberry, K.A. and Robinson, N.E. editors. 7th ed., United States, Elsevier, pp: 549.
Marti, E., Urwyler, A., Neuenschwander, M., Eicher, R., Meier, D., De Weck, A.L., et al. (1999). Sulfidoleukotriene generation from peripheral blood leukocytes of horses affected with insect bite dermal hypersensitivity. Veterinary Immunology and Immunopathology, 71(3-4): 307-320.
Morris, D.O. and Lindborg, S. (2003). Determination of ‘irritant’ threshold concentrations for intradermal testing with allergenic insect extracts in normal horses. Veterinary Dermatology, 14(1): 31-36.
Murphy, K. and Weaver, C. (2017). Janeway’s Immunobiology. 9th ed., New York and London, Garland Science, pp: 612-619.
O'Neill, W., McKee, S. and Clarke, A.F. (2002). Flaxseed (Linum usitatissimum) supplementation associated with reduced skin test lesional area in horses with Culicoides hypersensitivity. Canadian Journal of Veterinary Research, 66(4): 272.
Pilsworth, R. and Knottenbelt, D. (2004). Equine insect hypersensitivity. Equine Veterinary Education, 16(6): 324-325.
Quinn, P., Baker, K. and Morrow, A. (1983). Sweet itch: responses of clinically normal and affected horses to intradermal challenge with extracts of biting insects. Equine Veterinary Journal, 15(3): 266-272.
Riek, R. (1953), Studies on allergic dermatitis (Queensland itch) of the horse: I-description, distribution, symptoms and pathology. Australian Veterinary Journal, 29(7): 177-184.
Schaffartzik, A., Hamza, E., Janda, J., Crameri, R., Marti, E. and Rhyner, C. (2012). Equine insect bite hypersensitivity: what do we know? Veterinary Immunology and Immunopathology, 147(3-4): 113-126.
Van Grevenhof, E., Ducro, B., Heuven, H. and Bijma, P. (2007). Identification of environmental factors affecting the prevalence of insect bite hypersensitivity in Shetland ponies and Friesian horses in the Netherlands. Equine Veterinary Journal, 39(1): 69-73.
White, S.D. (2015). Diseases of the Skin. In: Large Animal Internal Medicine. Smith, B.P. editor. 5th ed., United Kingdom, Elsevier, pp: 1208.
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Althaus, H., Muller, N., Busato, A., Mellor, P., Torsteinsdottir, S.and Marti, E. (2004). Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera). Veterinary Immunology and Immunopathology, 99(1-2): 99-111.
Anderson, G.S., Belton, P. and Kleider, N. (1988). The hypersensitivity of horses to Culicoides bites in British Columbia. The Canadian Veterinary Journal, 29(9): 718.
Anderson, G., Belton, P. and Kleider, N. (1991). Culicoides obsoletus (Diptera: Ceratopogonidae) as a causal agent of Culicoides hypersensitivity (sweet itch) in British Columbia. Journal of Medical Entomology, 28(5): 685-693.
Baker, K. and Collins, E. (1984). A disease resembling sweet itch in Hong Kong. Equine Veterinary Journal, 16(5): 467-468.
Baker, K. and Quinn, P. (1978). A report on clinical aspects and histopathology of sweet itch. Equine Veterinary Journal, 10(4): 243-248.
Brostrom, H., Larsson, A. and Troedsson, M. (1987). Allergic dermatitis (sweet itch) of Icelandic horses in Sweden: an epidemiological study. Equine Veterinary Journal, 19(3): 229-236.
Constable, P.D., Hinchcliff, K.W., Done, S.H. and Grunberg, W. (2017). Veterinary Medicine, 11th ed., Missouri, Elsevier, pp: 1552, 1559-1560.
Fadok, V.A. and Greiner, E. (1990). Equine insect hypersensitivity: skin test and biopsy results correlated with clinical data. Equine Veterinary Journal, 22(4): 236-240.
Gerhardt, R.R. (1986). Culicoides spp. attracted to ruminants in the Great Smoky Mountains National Park, Tennessee. Journal of Agricultural Entomology, 3(2): 192-197.
Gould, H.J. and Sutton, B.J. (2008). IgE in allergy and asthma today. Nature Reviews Immunology, 8(3): 205-217.
Halldórdsóttir, S. and Larsen, H. (1991). An epidemiological study of summer eczema in Icelandic horses in Norway. Equine Veterinary Journal, 23(4): 296-299.
Henry, A. and Bory, L. (1937). Dermatose estivale recidivante du cheval. Pathologie et therapeutique. Recueil de Medecine Veterinaire, 113: 65-78. Quoted by: Brostrom, H., Larsson, Å and Troedsson, M. (1987). Allergic dermatitis (sweet itch) of Icelandic horses in Sweden: an epidemiological study. Equine Veterinary Journal, 19(3): 229-236.
Knottenbelt, D.C. (2009). Pascoes: Principles and Practice of Equine Dermatology, 2th ed., United Kingdom, Elsevier, pp: 284-286.
Kleider, N. and Lees, M. (1984). Culicoides hypersensitivity in the horse: 15 cases in southwestern British Columbia. The Canadian Veterinary Journal, 25(1): 26-32.
Kolm‐Stark, G. and Wagner, R. (2002). Intradermal skin testing in Icelandic horses in Austria. Equine Veterinary Journal, 34(4): 405-410.
Kurotaki, T., Narayama, K., Oyamada, T., Yoshikawa, H. and Yoshikawa, T. (1994). Immunopathological study on equine insect hypersensitivity (“kasen”) in Japan. Journal of Comparative Pathology, 110(2): 145-152.
Lange, S., Hamann, H., Deegen, E., Ohnesorge, B. and Distl, O. (2005). Investigation of the prevalence of summer eczema in Icelandic horses in northern Germany. Berliner und Munchener Tierarztliche Wochenschrift, 118(11-12): 481-489.
Langner, K.F., Darpel, K.E., Drolet, B.S., Fischer, A., Hampel, S., Heselhaus, J.E., et al. (2008). Comparison of cellular and humoral immunoassays for the assessment of summer eczema in horses. Veterinary Immunology and Immunopathology, 122(1-2): 126-137.
Lloyd, D.H., Littlewood, J.D., Craig, J.M. and Thomset, L.R. (2003). Practical Equine Dermatology. 2th ed., Denmark, Blackwell, pp: 18-20.
Littlewood, J.D. and Heidmann, P. (2006). The skin. In: Higgins. In: The Equine Manual. D.J. and Snyder, J.R. editors. 2nd ed., China, Elsevier, pp: 369-372.
Marsella, R. (2013). Equine allergy therapy: update on the treatment of environmental, insect bite hypersensitivity, and food allergies. Veterinary Clinics: Equine Practice, 29(3): 551-557.
Marsella, R. (2015). Ventral dermatitis. In: Robinsons Current Therapy in Equine medicine. Sprayberry, K.A. and Robinson, N.E. editors. 7th ed., United States, Elsevier, pp: 549.
Marti, E., Urwyler, A., Neuenschwander, M., Eicher, R., Meier, D., De Weck, A.L., et al. (1999). Sulfidoleukotriene generation from peripheral blood leukocytes of horses affected with insect bite dermal hypersensitivity. Veterinary Immunology and Immunopathology, 71(3-4): 307-320.
Morris, D.O. and Lindborg, S. (2003). Determination of ‘irritant’ threshold concentrations for intradermal testing with allergenic insect extracts in normal horses. Veterinary Dermatology, 14(1): 31-36.
Murphy, K. and Weaver, C. (2017). Janeway’s Immunobiology. 9th ed., New York and London, Garland Science, pp: 612-619.
O'Neill, W., McKee, S. and Clarke, A.F. (2002). Flaxseed (Linum usitatissimum) supplementation associated with reduced skin test lesional area in horses with Culicoides hypersensitivity. Canadian Journal of Veterinary Research, 66(4): 272.
Pilsworth, R. and Knottenbelt, D. (2004). Equine insect hypersensitivity. Equine Veterinary Education, 16(6): 324-325.
Quinn, P., Baker, K. and Morrow, A. (1983). Sweet itch: responses of clinically normal and affected horses to intradermal challenge with extracts of biting insects. Equine Veterinary Journal, 15(3): 266-272.
Riek, R. (1953), Studies on allergic dermatitis (Queensland itch) of the horse: I-description, distribution, symptoms and pathology. Australian Veterinary Journal, 29(7): 177-184.
Schaffartzik, A., Hamza, E., Janda, J., Crameri, R., Marti, E. and Rhyner, C. (2012). Equine insect bite hypersensitivity: what do we know? Veterinary Immunology and Immunopathology, 147(3-4): 113-126.
Van Grevenhof, E., Ducro, B., Heuven, H. and Bijma, P. (2007). Identification of environmental factors affecting the prevalence of insect bite hypersensitivity in Shetland ponies and Friesian horses in the Netherlands. Equine Veterinary Journal, 39(1): 69-73.
White, S.D. (2015). Diseases of the Skin. In: Large Animal Internal Medicine. Smith, B.P. editor. 5th ed., United Kingdom, Elsevier, pp: 1208.
