کارسینومای غده هپاتوئید در سگ: گزارش موردی
محورهای موضوعی :
آسیب شناسی درمانگاهی دامپزشکی
فرشاد باغبان
1
,
امین بیاتی
2
1 - استادیار گروه دامپزشکی، واحد یاسوج، دانشگاه آزاد اسلامی، یاسوج، ایران.
2 - دانش‌آموخته دکترای حرفه‌ای دامپزشکی، دانشکده دامپزشکی، واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران.
تاریخ دریافت : 1398/03/18
تاریخ پذیرش : 1398/08/21
تاریخ انتشار : 1399/02/01
کلید واژه:
هیستوپاتولوژی,
سگ,
غده هپاتوئید,
کارسینوما,
چکیده مقاله :
غدد هپاتوئید یا غدد اطراف مقعدی در سگ‌سانان، غدد سباسه تغییر شکل یافته‌ای هستند که در بافت‌‌‌های زیر‌جلدی اطراف ناحیه مقعدی در سگ های نر و ماده یافت می‌شوند. در مقایسه با آدنوماهای غدد هپاتوئید، کارسینوماهای این غدد با فراوانی کمتری رخ می‌دهند. به‌‌‌‌‌‌علاوه تومورهای این غدد گاهی به صورت نابجا بر روی سطح خارجی سایراندام‌‌ها مانند دم، ناحیه پرینه، غلاف قضیب، تهیگاه، ران، پشت، ناحیه کمری–خاجی، خط میانی شکم، گونه، سر و گردن دیده می‌شوند. گزارش حاضر دو مورد کارسینومای غده هپاتوئید نابجا را در دو قلاده سگ نژاد تریر و ژرمن شفرد از نظر هیستوپاتولوژی شرح می‌دهد. مورد اول مربوط به یک قلاده سگ نر نژاد تریر با سن 18 سال بود که توده توموری با قوامی نسبتاً سفت در ملامسه و بدون درد، امابا ظاهری اولسراتیو و توأم با خونریزی به صورت نابجا بر روی ناحیه تهیگاه و دست چپ حیوان رشد کرده بود. مورد دوم هم مربوط به یک قلاده سگ نر نژاد ژرمن شفرد 10 ساله بود که حیوان به‌‌دلیل وجود توده‌ای بزرگ و زخمی با قوامی سفت در ملامسه در ناحیه پشت گردن به درمانگاه ارجاع داده شده بود. سگ مذکور به دلیل ماهیت زخمی و عفونی بودن توده توموری، تب دار و بی اشتها بود. در بررسی هیستوپاتولوژی ضایعات، در هر دو مورد تکثیر و تزاید سلول‌های هپاتوئید، اشکال میتوزی، پرخونی، خونریزی، نکروز و نفوذ سلول‌های التهابی به ویژه نوتروفیل‌ها مشاهده گردید.
چکیده انگلیسی:
The hepatoid glands or the perianal glands in canidae are transformed sebaceous glands found in the subcutaneous tissues around the anal region in male and female dogs. In Comparison with adenomas of the hepatoid glands, carcinomas of these glands occur with less frequency. In addition, tumors of these glands are occasionally observed ectopically on the outer surface of other organs such as tail, perineal area, prepuce, flank, thighs, back, lumbosacral area, midline of the abdomen, chin, head and neck. This report describes histopathological features of two cases of ectopic hepatoid gland carcinomas in two breeds of Terrier and German shepherd dogs. The first case was a Terrier dog, male, 18 years old with the tumor having a relatively hard consistency on palpation, without pain and ulcerative appearance along with hemorrhage which had grown on the flank region and the left hand ectopically. The second case was a German shepherd dog, male, 10 years old, which was referred to the clinic due to existence of a large and ulcerative mass with hard consistency in palpation on the back of the neck. The dog was febrile and anorexic because of ulcerative and infectious nature of the tumoral mass. In histopathological examination of the lesions in both cases, proliferation of hepatoid cells, mitotic figures, congestion, hemorrhage, necrosis and infiltration of inflammatory cells, especially neutrophils was observed.
منابع و مأخذ:
Atoji, Y., Yamamoto, Y., Komatsu, T., Suzuki, Y. and Tsubota, T. (1989). Circumanal glands of the dog: A new classification and cell degeneration. The Anatomical Record, 250(3): 251-267.
Bennett, P.F., DeNicola D.B., Bonney, P., Glickman, N.W. and Knapp, D.W. (2002). Canine anal sac adenocarcinomas: Clinical presentation and response to therapy. Journal of Veterinary Internal Medicine, 16(1): 100-104.
Berrocal, A., Vos, J.H., Van Den Ingh, T., Molenbeek, R.F. and Van Sluijs, F.J. (1989). Canine perianal tumors. Zentralblatt fur Veterinarmedizin, 36(10): 739-749.
Devi, L.G., Choudhari, A., Singh, N.D., Banga, H.S. and Gadhave, P.D. (2012). An incidental case of perianal gland adenoma in a stray dog. Scientific Journal of Animal Science, 1(2): 71-74.
Doustar, Y., Mohajeri, D. and Kafash Elahi, R. (2010) Comparison of apoptosis in canine transmissible venereal tumor (TVT) pre and post chemotherapy with vincristine sulphate. Journal of Veterinary Clinical Pathology, 3(15): 869-874. [In Persian]
Goldschmidt, M.H. and Hendrick, M.J. (2002). Tumors of the skin and soft tissues. In: Tumors in domestic animals. Meuten, D.J. editor. 4th ed., USA: Iowa, Iowa State Press, pp: 45-117.
Hayes, H.M. and Wilson, G.P. (1977). Hormone-dependent neoplasms of the canine perianal gland. Cancer Research, 37(7 pt 1): 2068-2071.
Jardim, J., Kobayashi, P.E., Cosentino, P.D., Alcaraz, A., Laufer-Amorim, R. and Fonseca-Alves, C.E. (2018). Clinicopathological and immunohistochemical description of an intrapelvic hepatoid gland carcinoma in a 14-year-old Teckel dog. Veterinary Quarterly, 38(1): 9-13.
Kim, S.H., Seung, B.J., Cho, S.H., Lim, H.Y., Park, H.M. and Sur, H.J. (2018) Increased p63 expression in canine perianal gland tumors. Journal of Veterinary Research, 62(2): 229-235.
Kokila, S., Veena, P., Suresh Kumar, R.V., Sankar, P., Dhana Lakshmi, N., Srilatha, Ch., et al. (2012). Hepatoid adenocarcinoma of anal region in a dog. Indian Journal of Veterinary Pathology, 36 (2): 236-237.
Nielsen, S.W. and Aftosmis, J. (1964). Canine Perianal Gland Tumors. Journal of American Veterinary Medical Association, 144: 127-135.
Pisani, G., Millanta, F., Lorenzi, D., Vannozzi, I. and Poli, A. (2006). Androgen receptor expression in normal, hyperplastic and neoplastic perianal glands in the dog. Research of Veterinary Science, 81(2): 231-236.
Sharif, M.A.M. (2006). Epidemiology of skin tumors entities according to the new WHO classification in dogs and cats. Germany: VVB, Laufersweiler Verlag, Giessen, pp: 1-190.
Spugnini, E.P., Dotsinsky, I., Mudrov, N., Cardosi, G., Citro, G., D'Avino, A., et al. (2012). Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model. Journal of Experimental and Clinical Cancer Research, 26(4): 483-487.
Trangadia, B.J., Patel, J.M., Vihol, P.D., Prasad, M.C., Suthar, D.N. and Tyagi, S.K. (2014). Pathology of perianal gland tumours in dogs. Indian Journal of Veterinary Pathology, 38(2): 122-123.
Vail, D.M., Withrow, S.J., Schwarz, P.D. and Powers, B.E. (1990). Perianal adenocarcinoma in the canine male: a retrospective study of 41 cases. Journal of American Animal Hospital Association, 26(3): 329-334.
Wheler, C.L. and Pocknell, A.A. (1996). Ectopic perianal gland tumor in a timber wolf. Canadian Veterinary Journal, 37(1): 41-42.
Wilson, G.P. and Hayes, H.M. (1979). Castration for treatment of perianal gland neoplasms in the dog. Journal of American Veterinary Medicine Association, 174(12): 1301-1303.
Yumusak, N., Çaliskan, M. and Kutsal, O. (2016). Fine needle aspiration cytology (FNAC) in the diagnosis of canine hepatoid gland tumors- A comparative study with histopathology. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63(3): 259-266.
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Atoji, Y., Yamamoto, Y., Komatsu, T., Suzuki, Y. and Tsubota, T. (1989). Circumanal glands of the dog: A new classification and cell degeneration. The Anatomical Record, 250(3): 251-267.
Bennett, P.F., DeNicola D.B., Bonney, P., Glickman, N.W. and Knapp, D.W. (2002). Canine anal sac adenocarcinomas: Clinical presentation and response to therapy. Journal of Veterinary Internal Medicine, 16(1): 100-104.
Berrocal, A., Vos, J.H., Van Den Ingh, T., Molenbeek, R.F. and Van Sluijs, F.J. (1989). Canine perianal tumors. Zentralblatt fur Veterinarmedizin, 36(10): 739-749.
Devi, L.G., Choudhari, A., Singh, N.D., Banga, H.S. and Gadhave, P.D. (2012). An incidental case of perianal gland adenoma in a stray dog. Scientific Journal of Animal Science, 1(2): 71-74.
Doustar, Y., Mohajeri, D. and Kafash Elahi, R. (2010) Comparison of apoptosis in canine transmissible venereal tumor (TVT) pre and post chemotherapy with vincristine sulphate. Journal of Veterinary Clinical Pathology, 3(15): 869-874. [In Persian]
Goldschmidt, M.H. and Hendrick, M.J. (2002). Tumors of the skin and soft tissues. In: Tumors in domestic animals. Meuten, D.J. editor. 4th ed., USA: Iowa, Iowa State Press, pp: 45-117.
Hayes, H.M. and Wilson, G.P. (1977). Hormone-dependent neoplasms of the canine perianal gland. Cancer Research, 37(7 pt 1): 2068-2071.
Jardim, J., Kobayashi, P.E., Cosentino, P.D., Alcaraz, A., Laufer-Amorim, R. and Fonseca-Alves, C.E. (2018). Clinicopathological and immunohistochemical description of an intrapelvic hepatoid gland carcinoma in a 14-year-old Teckel dog. Veterinary Quarterly, 38(1): 9-13.
Kim, S.H., Seung, B.J., Cho, S.H., Lim, H.Y., Park, H.M. and Sur, H.J. (2018) Increased p63 expression in canine perianal gland tumors. Journal of Veterinary Research, 62(2): 229-235.
Kokila, S., Veena, P., Suresh Kumar, R.V., Sankar, P., Dhana Lakshmi, N., Srilatha, Ch., et al. (2012). Hepatoid adenocarcinoma of anal region in a dog. Indian Journal of Veterinary Pathology, 36 (2): 236-237.
Nielsen, S.W. and Aftosmis, J. (1964). Canine Perianal Gland Tumors. Journal of American Veterinary Medical Association, 144: 127-135.
Pisani, G., Millanta, F., Lorenzi, D., Vannozzi, I. and Poli, A. (2006). Androgen receptor expression in normal, hyperplastic and neoplastic perianal glands in the dog. Research of Veterinary Science, 81(2): 231-236.
Sharif, M.A.M. (2006). Epidemiology of skin tumors entities according to the new WHO classification in dogs and cats. Germany: VVB, Laufersweiler Verlag, Giessen, pp: 1-190.
Spugnini, E.P., Dotsinsky, I., Mudrov, N., Cardosi, G., Citro, G., D'Avino, A., et al. (2012). Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model. Journal of Experimental and Clinical Cancer Research, 26(4): 483-487.
Trangadia, B.J., Patel, J.M., Vihol, P.D., Prasad, M.C., Suthar, D.N. and Tyagi, S.K. (2014). Pathology of perianal gland tumours in dogs. Indian Journal of Veterinary Pathology, 38(2): 122-123.
Vail, D.M., Withrow, S.J., Schwarz, P.D. and Powers, B.E. (1990). Perianal adenocarcinoma in the canine male: a retrospective study of 41 cases. Journal of American Animal Hospital Association, 26(3): 329-334.
Wheler, C.L. and Pocknell, A.A. (1996). Ectopic perianal gland tumor in a timber wolf. Canadian Veterinary Journal, 37(1): 41-42.
Wilson, G.P. and Hayes, H.M. (1979). Castration for treatment of perianal gland neoplasms in the dog. Journal of American Veterinary Medicine Association, 174(12): 1301-1303.
Yumusak, N., Çaliskan, M. and Kutsal, O. (2016). Fine needle aspiration cytology (FNAC) in the diagnosis of canine hepatoid gland tumors- A comparative study with histopathology. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 63(3): 259-266.
