بررسی اثر نانوذره سلنیم و سلنیت سدیم بر بیان ژن ادیپونکتین در جفت میش‌های آبستن
محورهای موضوعی :
آسیب شناسی درمانگاهی دامپزشکی
پدرام معیری
1
,
غلام علی کجوری
2
,
افشین جعفری دهکردی
3
,
علی محمد احدی
4
,
مهسا ابوالفضل زاده
5
1 - دانش‌آموخته دکترای تخصصی بیماری‌های داخلی دام‌های بزرگ، گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
2 - استاد گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
3 - دانشیار گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران.
4 - استادیار گروه ژنتیک، دانشکده علوم، دانشگاه شهرکرد، شهرکرد، ایران.
5 - کارشناس پرستاری، واحد آستارا، دانشگاه آزاد اسلامی، آستارا، ایران.
تاریخ دریافت : 1396/11/26
تاریخ پذیرش : 1398/05/08
تاریخ انتشار : 1398/09/01
کلید واژه:
سلنیت سدیم,
تجویز خوراکی,
نانوذره سلنیوم,
ادیپونکتین,
میش‌های آبستن,
چکیده مقاله :
در سال‌های اخیر توجهی ویژه به واسطه‌های مقاومت انسولینی نظیر ادیپونکتین شده است که در دوران آبستنی در بافت جفت تولید و بیان شده و از این طریق اثرات خود را بر جنین در حال رشد و سلامت مادر القاء می کنند. در این مطالعه برای اولین بار، تأثیر نانوذره سلنیم و سلنیت سدیم بر میزان نسخه‌برداری ژن ادیپونکتین بافت جفت در دوره انتقالی مورد مطالعه قرار گرفت. به این منظور، 20 رأس میش 4 ماهه آبستن، به‌صورت تصادفی انتخاب و در زمان 10 روز منتهی به زایمان، هر روز تجویز خوراکی مکمل‌های سلنیت سدیم (به میزان 1/0 میلی‌گرم به ازای هر کیلوگرم وزن بدن) و نانوذره سلنیوم (در دو دوز 05/0 و 1/0 میلی‌گرم به ازای هرکیلوگرم وزن بدن) به آن ها صورت گرفت. به گروه شاهد هم آب مقطر با حجم مشابه خورانده شد. پس از زایمان با نمونه‌برداری از جفت، میزان نسخه‌برداری از ژن ادیپونکتین به روش real-time RT-PCR و بر اساس روش مقایسه‌ای ΔΔCt-2 تعیین شد. نتایج حاصله نشان داد که اضافه نمودن مکمل‌های سلنیومی به جیره غذایی میش‌های آبستن، موجب کاهش معنی‌دار در میزان نسخه‌برداری ژن ادیپونکتین می‌شود که در این خصوص، عملکرد سرکوب‌گری نانوذره سلنیوم به مراتب برتر از سلنیت سدیم بود.
چکیده انگلیسی:
In recent years, special attention has been paid to insulin resistance mediators, such as adiponectin, that is produced and expressed during conception in placental tissue, thereby inducing its effects on the growing embryo and the health of the mother.In this study, the effect of selenium nanoparticles and sodium selenite on transcription of placental adiponectin gene was investigated for the first time during the transitional period. For this purpose, 20 pregnant ewes were selected randomly. During the 10 days leading up to birth, oral administration of selenium nanoparticles (Se NPs) with dosages of 0.05 and 0.10 mg/kg B.W. and sodium selenite with dosage of 0.1 mg/kg B.W. was performed. At the same time, the control group received equal volume of distilled water. At parturition, placental samples were collected and the transcription rate of adiponectin gene was determined by using RT-PCR based on a comparison assay of 2-ΔΔCt.The results showed that selenium supplementation in pregnant ewes leads to a significant reduction in adiponectin gene transcription rate and the suppressive role of selenium nanoparticles was significantly superior to sodium selenite.
منابع و مأخذ:
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Lappas, M., Yee, K., Permezel, M. and Rice, G.E. (2005). Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. Journal of Endocrinology, 186(3): 457-465.
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Liu, Y.M., Lacorte, J.M., Viguerie, N., Poitou, C., Pelloux, V.R., Guy-Grand, B., et al. (2003). Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding. The Journal of Clinical Endocrinology and Metabolism, 88(12): 5881-5886.
Lu, M., Tang, Q., Olefsky, J.M., Mellon, P.L. and Webster, N.J. (2008). Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes. Molecular Endocrinology, 22(3): 760-771.
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y. and Matsubara, K. (1996). cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPoseMost abundant Gene transcript 1). Biochemical and Biophysical Research Communications, 221(2): 286-289.
Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., et al. (2002). Role of adiponectin in preventing vascular stenosis the missing link of adipo-vascular axis. Journal of Biological Chemistry, 277(40): 37487-37491.
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Bansal, N., Charlton-Menys, V., Pemberton, P., Mcelduff, P., Oldroyd, J., Vyas, A., et al. (2006). Adiponectin in umbilical cord blood is inversely related to low-density lipoprotein cholesterol but not ethnicity. The Journal of Clinical Endocrinology and Metabolism, 91(6): 2244-2249.
Barb, D., Williams, C.J., Neuwirth, A.K. and Mantzoros, C.S. (2007). Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. The American Journal of Clinical Nutrition, 86(3): 858S-866S.
Cnop, M., Havel, P., Utzschneider, K., Carr, D., Sinha, M., Boyko, E., et al. (2003). Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia, 46(4): 459-469.
Collier, R.J. and Collier, J. (2011). Environmental physiology of livestock. USA: Iowa, John Wiley and Sons, pp: 81-181.
Dorounaki, M., Rostami, B., Harkinezhad, T. and Shahir, M.H. (2017). Gene expression of adiponectin and its receptor2 (AdipoR2) in reproductive tract of growing prepubertal Afshari male lambs. Iranian Journal of Animal Science Research, 8(4): 667-676.
Economides, S. (1986). Nutrition and management of sheep and goats. Small Ruminant Production In The Developing Countries, 86: 61-73.
Ehrhardt, R.A. and Bell, A.W. (1997). Developmental increases in glucose transporter concentration in the sheep placenta. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 273(3): R1132-R1141.
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M. and Paschke, R. (2002). Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications, 290(3): 1084-1089.
Fasshauer, M., Kralisch, S., Klier, M., Lossner, U., Bluher, M., Klein, J., et al. (2003). Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications, 301(4): 1045-1050.
Fruebis, J., Tsao, T.S., Javorschi, S., Ebbets-Reed, D., Erickson, M.R.S., Yen, F.T., et al. (2001). Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences, 98(4): 2005-2010.
Gan, L., Liu, Q., Xu, H.-B., Zhu, Y.S. and Yang, X.L. (2002). Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities. Biological Trace Element Research, 89(2): 165-175.
Halleux, C. M., Takahashi, M., Delporte, M.L., Detry, R., Funahashi, T., Matsuzawa, Y., et al. (2001). Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochemical and Biophysical Research Communications, 288(5): 1102-1107.
Hanley, A.J., Bowden, D., Wagenknecht, L.E., Balasubramanyam, A., Langfeld, C., Saad, M.F., et al. (2007). Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans. The Journal of Clinical Endocrinology and Metabolism, 92(7): 2665-2671.
Hu, E., Liang, P. and Spiegelman, B.M. (1996). AdipoQ is a novel adipose-specific gene dysregulated in obesity. Journal of Biological Chemistry, 271(18): 10697-10703.
Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M., et al. (2003). Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes, 52(7): 1655-1663.
Izadi, V. and Azadbakht, L. (2013). Association between cancer and serum adiponectin level: The review of epidemiologic evidences. Journal of Shahrekord University of Medical Sciences, 15(5): 97-110. [In Persian]
Jablonska, E., Reszka, E., Gromadzinska, J., Wieczorek, E., Krol, M.B., Raimondi, S., et al. (2016). The effect of selenium supplementation on glucose homeostasis and the expression of genes related to glucose metabolism. Nutrients, 8(12): 772-780.
Jardé, T., Caldefie-Chézet, F., Goncalves-Mendes, N., Mishellany, F., Buechler, C., Penault-Llorca, F., et al. (2009). Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocrine-Related Cancer, 16(4): 1197-1210.
Kadowaki, T. and Yamauchi, T. (2005). Adiponectin and adiponectin receptors. Endocrine Reviews, 26(3): 439-451.
Kaklamani, V. G., Sadim, M., Hsi, A., Offit, K., Oddoux, C., Ostrer, H., et al. (2008). Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Research, 68(9): 3178-3184.
Kelesidis, I., Kelesidis, T. and Mantzoros, C. (2006). Adiponectin and cancer: a systematic review. British Journal of Cancer, 94(9): 1221-1225.
Kharroubi, I., Rasschaert, J., Eizirik, D.L. and Cnop, M. (2003). Expression of adiponectin receptors in pancreatic β cells. Biochemical and Biophysical Research Communications, 312(4): 1118-1122.
Kissebah, A.H., Sonnenberg, G.E., Myklebust, J., Goldstein, M., Broman, K., James, R.G., et al. (2000). Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proceedings of the National Academy of Sciences, 97(26): 14478-14483.
Kojouri, G. and Shirazi, A. (2007). Serum concentrations of Cu, Zn, Fe, Mo and Co in newborn lambs following systemic administration of Vitamin E and selenium to the pregnant ewes. Small Ruminant Research, 70(2): 136-139.
Kojouri, G.A., Sadeghian, S., Mohebbi, A. and Dezfouli, M.R.M. (2012). The effects of oral consumption of selenium nanoparticles on chemotactic and respiratory burst activities of neutrophils in comparison with sodium selenite in sheep. Biological Trace Element Research, 146(2): 160-166.
Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., et al. (2007). Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metabolism, 6(1): 55-68.
Lappas, M., Yee, K., Permezel, M. and Rice, G.E. (2005). Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. Journal of Endocrinology, 186(3): 457-465.
Lashgari, A., Rustami, B. and Shahir, M.H.E. (2013). valuation of changes in adiponectin gene expression at different stages of pregnancy in Afshari ewe breeding system In Proceedings of First National Agricultural and Sustainable Natural Resources Conference, https://www.civilica.com/Paper-NACONF01-NACONF01_0996.html [In Persian]
Liu, Y.M., Lacorte, J.M., Viguerie, N., Poitou, C., Pelloux, V.R., Guy-Grand, B., et al. (2003). Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding. The Journal of Clinical Endocrinology and Metabolism, 88(12): 5881-5886.
Lu, M., Tang, Q., Olefsky, J.M., Mellon, P.L. and Webster, N.J. (2008). Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes. Molecular Endocrinology, 22(3): 760-771.
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y. and Matsubara, K. (1996). cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPoseMost abundant Gene transcript 1). Biochemical and Biophysical Research Communications, 221(2): 286-289.
Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., et al. (2002). Role of adiponectin in preventing vascular stenosis the missing link of adipo-vascular axis. Journal of Biological Chemistry, 277(40): 37487-37491.
Misu, H., Ishikura, K., Kurita, S., Takeshita, Y., Ota, T., Saito, Y., et al. (2012). Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. PloS One, 7(4): e34952.
Mitchell, M., Armstrong, D., Robker, R. and Norman, R. (2005). Adipokines: implications for female fertility and obesity. Reproduction, 130(5): 583-597.
Mohammadi, G., Saeb, S. and Arazzadeh, M. (2011). Effect of type 1 diabetes on the expression of adiponectin receptor gene in pancreas in male rats. Iranian Journal of Diabetes and Lipid, 10(6): 601-607. [In Persian]
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