A simulation study of calcium release channel

Subject Areas : Journal of Physical & Theoretical Chemistry

M.  Monajjemi ¹ (Not-mentioned)
H.H.  Haeri ² (Not-mentioned)
S.M.  Hashemianzadeh ³ (Not-mentioned)
M.  Gholami ⁴ (Not-mentioned)
K.  Zare ⁵ (Not-mentioned)

Received: 2015-05-09 Accepted : 2015-05-09 Published : 2005-11-01

Keywords: Ion channel, DeYoung-Keizer model, Stochastisity, Gillespie algorithm, Monte Carlo, Complex&#x0D, &#x0D, reactions,

Abstract :

The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The degree ofinhibition may depend on the IP3 concentration. Different levels of inhibition have seen in differentinhibited states. Using the Gillespie algorithm, the frequency graphs for each set of Ca+2 and IP3concentrations and in different time domains can be achieved. The probability of open channel increaseswith going from small time domain to large time domain. A good consistency can be inferred comparingwith different results from the past studies (Both in theoretical and experimental studies).A reaction patternin fast time domain has seen, too.