Effect of aerobic exercise on dehydroepianderestrone and cortisol in in female patients with multiple sclerosis

Subject Areas : Journal of Physical Activity and Hormones

Fatemeh  Zare ¹ (MS in Exercise Physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran)

Received: 2017-10-06 Accepted : 2017-11-03 Published : 2018-02-01

Keywords: Cortisol, Aerobic training, Multiple Sclerosis, DHEA-S,

Abstract :

Introduction: The aim of this study was to examine the effects of 8 weeks aerobic training on dehydroepianderestrone sulfate (DHEA-S) and cortisol in female patients with multiple sclerosis disease. Material & Methods: Twenty seven women with MS disease in a range of 20-47 year of old and EDSS lower than 5.5 participated in this study as the subject. Subjects were divided into control group (n=14) or training group (n=13) randomly. The training group performed aerobic training program, 3 days a week for 8 weeks according to 55-60 percentage of VO2max. The control group was in absolute rest at the same time. Serum level of DHEA-S and cortisol were measured by ELISA kits before and after training. Results: The results showed that cortisol and DHEA-S concentrations did not change significantly after the intervention. Conclusions: In conclusion, the results suggest aerobic training with specific intensity and duration utilized in this study had not effects on cortisol and DHEA-S levels in female patients with MS.

References:

References

1. Huitinga I, Erkut ZA, van Beurden D, Swaab DF. The hypothalamo-pituitary-adrenal axis in multiple sclerosis. Ann N Y Acad Sci 2003; 992:118-128.

2. Huitinga I, Erkut ZA, van Beurden D, Swaab DF. The hypothalamo-pituitary-adrenal axis in multiple sclerosis. Ann N Y Acad Sci 2003; 992:118-128.

3. MacPhee IA, Antoni FA, Mason DW. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J Exp Med 1989; 169:431-445.

4. Sarlis NJ, Chowdrey HS, Stephanou A, Lightman SL. Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat. Endocrinology 1992; 130:1775-1779.

5. Neeck G, Federlin K, Graef V, Rusch D, Schmidt KL. Adrenal secretion of cortisol in patients with rheumatoid arthritis. J Rheumatol 1990; 17:24-29.

6. Chikanza IC, Petrou P, Kingsley G, Chrousos G, Panayi GS. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 1992; 35:1281-1288.

7. Polman CH, Uitdehaag BM. Drug treatment of multiple sclerosis. BMJ 2000; 321:490-494.

8. Gold R, Buttgereit F, Toyka KV. Mechanism of action of glucocorticosteroid hormones: possible implications for therapy of neuroimmunological disorders. J Neuroimmunol 2001; 117:1-8

9. Charoensri S, Chailurkit L, Muntham D, Bunnag P. Serum dehydroepiandrosterone sulfate in assessing the integrity of the hypothalamic-pituitary-adrenal axis. J Clin Transl Endocrinol 2017; 7:42-46.

10. Nasrallah MP, Arafah BM. The value of dehydroepiandrosterone sulfate measurements in the assessment of adrenal function. J Clin Endocrinol Metab 2003; 88:5293-5298.

11. Sayyed Kassem L, El Sibai K, Chaiban J, Abdelmannan D, Arafah BM. Measurements of serum DHEA and DHEA sulphate levels improve the accuracy of the low-dose cosyntropin test in the diagnosis of central adrenal insufficiency. J Clin Endocrinol Metab 2012; 97:3655-3662.

12. Téllez N, Comabella M, Julià E, Río J, Tintoré M, Brieva L, et al. Fatigue in progressive multiple sclerosis is associated with low levels of dehydroepiandrosterone. Multiple Sclerosis 2006; 12:487-94.

13. Then Bergh F, Kümpfel T, Trenkwalder C, Rupprecht R, Holsboer F. Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS. Neurology 1999; 53:772-777.

14. Jassim HA, Ja'ffar FI, Hussein AG. Effect of moderate exercise on the level of DHEAS hormone and lymphocyte apoptosis in healthy subjects. J Faculty Med 2009; 52: 2232-2237.

15. Chang FE, Dodds WG, Sullivan M, Kim MH, Malarkey WB. The acute effects of exercise on prolactin and growth hormone secretion: comparison between sedentary women and women runners with normal and abnormal menstrual cycles. J Clin Endocrinol Metab 1986; 62:551-556.

16. Hays AE. Effect of an Acute Bout of Aerobic Exercise on Serum Dehydroepiadosterone Sulfate (DHEAS) Levels in Clinically Diagnosed Bipolar Patients. Doctoral Dissertation 2007.

17. Rashidfar S, Moghadasi M, Edalatmanesh MA. Effect of resistance training on dehydroepiandrestrone sulfate levels and fatigue in women with multiple sclerosis disease. Int J Curr Res Aca Rev 2014; 2:92-98.

18. Najafi P, Moghadasi M. The effect of yoga training on enhancement of Adrenocorticotropic hormone (ACTH) and cortisol levels in female patients with multiple sclerosis. Complement Ther Clin Pract 2017; 26:21-25.

19. Hejazi SM, Pakzadniya S, Moghaddam V, Ghiami SMM, Soltani M. The effect of the aerobic selected exercise in water on the cortisol level, IL–10, IL–6 and TGFβ in the patients with multiple sclerosis. J Basic Appl Sci Res, 2013; 3:23-28.

20. Schulz KH, Gold SM, Witte J, Bartsch K, Lang UE, Hellweg R, et al. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. J Neurol Sci 2004; 225:11-18.

21. Ziemssen T. Multiple sclerosis beyond EDSS: depression and fatigue. J Neurol Sci 2009; 277:S37-S41.

22. DeSousa EA, Albert RH, Kalman B. Cognitive impairments in multiple sclerosis: a review. Am J Alzheimers Dis Other Demen 2002; 17:23-29.

23. Dalgas U, Stenager E, Ingemann-Hansen T. Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance and combined training. Multiple Sclerosis 2008; 14:35-53.

24. White LJ, Dressendorfer RH. Exercise and multiple sclerosis. Sports Medicine 2004; 34: 1077-1100.

25. Straub RH, Zeuner M, Lock G, Scholmerich J, Lang B. High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis. Brit J Rheumatol 1997; 36:426-432.

26. Melief J, de Wit SJ, van Eden CG, Teunissen C, Hamann J, Uitdehaag BM, et al. HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter. Acta Neuropathol 2013; 126:237-249.

27. Heesen C, Gold SM, Raji A, Wiedemann K, Schulz KH. Cognitive impairment correlates with hypothalamo-pituitary-adrenal axis dysregulation in multiple sclerosis. Psychoneuroendocrinology 2002; 27:505-517.

28. Guyton AC, Hall JE. Textbook of medical physiology, Prism Books Pvt Limited, 1996.