Vitamin D3 Supplementation and Aquatic Exercise Combination as A Safe- Efficient Therapeutic Strategy to ameliorate Interleukin-6 and 10, and social interaction in Children with Autism

Subject Areas : Journal of Physical Activity and Hormones

Fahimeh  AdibSaber ¹ (Assistant Professor, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran)
Soleyman  Ansari Kolachahi ² (Ph.D. in Exercise Physiology, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran)
Alireza  Elmieh ³ (Associate Professor, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran)
Akbar  Allahyari Karnagh ⁴ (MA in Psychology, Department of Psychology, Rasht Branch, Islamic Azad University, Rasht, Iran)
Babak  Barkadehi ⁵ (Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran)

Received: 2023-05-07 Accepted : 2023-09-23 Published : 2023-09-01

Keywords: Swimming, interleukin-6, Children with autism, interleukin-10, vitamin D supplementation,

Abstract :

AbstractIntroduction: Increasing evidence demonstrated that there are altered levels of both pro- and anti-inflammatory cytokines in children with autism spectrum disorder (ASD) and pointed out that immune dysfunction may also relate to social deficits. This study investigated the effect of aquatic exercise combined with vitamin D supplementation on social interaction and two related cytokines (Interleukin-6 and Interleukin-10) in children with ASD.Material & Methods: Forty boys with ASD (mean age: 10.90; age range: 6–14 years) were randomly assigned to the three interventions (groups 1, 2, and 3) and one control group (each 10 participants). Participants in the group 1 and 3 received a 10-week aquatic exercise program. Subjects in groups 2 and 3 took orally 50,000 IU of vitamin D3/ week. We evaluated the serum levels of IL-6 and IL-10 and the participants' social interaction at baseline and post-intervention. Results:Compared to the control group, all three interventions improved social skills scores (p< 0.001). surprisingly, the combination strategy could significantly reduce IL-6 and increase IL-10 serum levels in children with ASD (p< 0.001).Conclusion: It is recommended that aqua-based exercise programs combined with vitamin D supplementation maximize the improvement of social and communication dysfunction in children with ASD.

References:

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