Electrospinning Nanofibers Gelatin scaffolds: Nanoanalysis of properties and optimizing the process for tissue engineering functional

Subject Areas : Journal of Nanoanalysis

Mohammad Jalili ¹ , abolfazl mozaffari ² , Mazeyar Gashti ³ , Masoud Parsania ⁴

1 - Department of Textile Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
2 - Azad university branch of Yazd
3 - Department of Textile Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran
4 - Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Received: 2019-12-25 Accepted : 2019-12-25 Published : 2019-12-01

Keywords: Morphology, Electrospinning, Nanofibers, Gelatin, Tissue Engineering,

Abstract :

Electrospinning has been recognized as an efficient technique for the fabrication of polymernanofibers. Recently, various polymers have successfully been electrospun into ultrafine fibers.Electrospinning is an extremely promising method for the preparation of tissue engineering scaffolds.In this study, nanofibers gelatin was electrospun at 20% v/v optimized content. To produce gelatinnanofibers optimally, production parameters need to be investigated. In the electrospinning, device(voltage and distance) parameters were determined to be effective; as a result, these parameterswere researched and the influences of electrospinning device parameters (voltage & distance)on properties of gelatin nanofibers were evaluated. These parameters affected the diametersize, uniformity, hydrophilicity and thermal degradation of electrospun gelatin nanofibers. All ofthese properties were examined by SEM, FTIR, CA, BET, XRAY and TGA tests and finally optimumgelatin nanofibers can be used in many applications including cell culture, drug delivery and tissueengineering.