Poly Ethylene Glycol-Stearate polymer in the design of nano-drug delivery system for oral administration by curcumin

Subject Areas : Journal of Nanoanalysis

Marzihe  Shahbazi ¹ (Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran)
Elham  Rostami ² (Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran)
maryam  kolahi ³ (Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran)
alireza  kiasat ⁴ (Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran)

Received: 2021-11-14 Accepted : 2022-03-16 Published : 2022-09-30

Keywords: Curcumin, Extraction, Drug release, Modification, Solid lipid nanoparticles,

Abstract :

In this work, Poly Ethylene Glycol- Stearate (PEG-SA) was used to prepare coated solid lipid nanoparticles (NPs) with loading curcumin extracted by Turmeric powder (cur-polymer coated-SLNs) by micro emulsification method. Evaluation of the release kinetic of prepared nanoparrticle was resulted. Particle size, zeta potential and polydispersity index were evaluated by Photon Correlation Spectroscopy (PCS). The particle size and zeta potential of cur PEG coated-SLNs had been measured as 153 nm. Differential scanning calorimetric indicated that the majority of curcumin loaded in PEG-NP was in amorphous state which is desirable for drug delivery. Drug entrapment efficiency (EE) was obtained 99%. The modification procedure led to a reduction in the zeta potential values, varying from -40.0 mV for the uncoated particles to -23 mV for that of (PEG-SA)-coated NP. FT-IR spectra and HPLC analysis of plain SLNs and pure curcumin exhibit no peak shifting and no loss of characteristic functional group peaks. Shape and surface morphology of particles were determined by transition electron microscopy and scanning electron microscopy that revealed spherical shape of nanoparticles. In vitro curcumin release of (PEG-SA)-coated SLNs and SLNs were showed the slight decrease performed for PEG-SA-SLNs one because of coating impact of covering layer.

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