Fabrication of nano S646 bioactive glass and the effect of adding it to chitosan nanocomposites / carbon nanotubes for bone regeneration

Subject Areas : Journal of Nanoanalysis

Fateme Mirjalili ¹ , Mahboobeh Mahmoodi ² , Farniya Mohammadifar ³

1 - Department of Material Engineering, Maybod Branch, Islamic Azad University, Maybod, Iran
2 - Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran | Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 - Department of Biomedical Engineering, Yazd Branch, Islamic Azad University, Yazd, Iran

Received: 2021-10-24 Accepted : 2022-02-22 Published : 2022-09-30

Keywords: MTT Assay, Chitosan, Carbon Nanotube, Bioglass of S646,

Abstract :

Nanoscale bioactive glasses have been gaining attention due to their superior osteoconductivity. The combination of bioactive glass nanoparticles with polymeric systems enables the production of nanocomposites with potential to be used in a series of orthopedic applications, including tissue engineering and regenerative.This research has been done to study characteristic and biocompatible evaluation of a nano bio composite ceramic. In this regard synthesis of this S646 bioactive glass has been considered afterwards, the bioglass S646/chitosan/carbon nanotube with different amount of S646 bioactive glass has been synthesized by sol-gel method. The synthesized nanoparticles and nanocomposite have been characterized with the help of different techniques, using field emission scanning electron microscope, x-ray powder diffraction, fourier-transform infrared spectroscopy to evaluate crystal structure, microstructure and morphology. The results indicated that, the synthesized bioglass S646/chitosan/carbon nantube nanocomposite with the average particle size of about 41-49 nm and percentages of crystallinity about 64-86% for all samples. Result of FTIR analyses showed that, the purity in the structure of bioglass of S646 and nano composites.The outcomes revealed that, with increase of the amount of S646 bioactive glass changed the shape of the particles from spherical and reduced the particle size, which owing to the increase of amorphous phase in the material which reduced the crystallinity and crystal size of nanocomposite particles. The result of MTT assay indicated nontoxicity and also increasing the percentage of bioactive glass also increased cell viability.

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